Results 61 to 70 of about 3,123 (186)
Clinical Epigenetics, 2023 Background N7-methylguanosine (m7G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment in heart failure (HF).
Chaoqun Ma +6 more
doaj +1 more source
Unravelling the molecular basis of the dominant negative effect of myosin XI tails on P-bodies.
PLoS ONE, 2021 The directional movement and positioning of organelles and macromolecules is essential for regulating and maintaining cellular functions in eukaryotic cells.
Lisa Stephan +4 more
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Dcp2 mutant flies fail to develop cNILH.
, 2012 A. Diagram of the Dcp2 genomic region with gene direction. The red vertical arrows indicate the P-element insertion sites of the Dcp2V1194, Dcp2c02419, and Dcp2e00034 mutant alleles. B–C.
Jing Ren (107777) +6 more
core +1 more source
Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain [PDF]
RNA, 2015 Decapping commits an mRNA to complete degradation and promotes general 5′ to 3′ decay, nonsense-mediated decay (NMD), and transcript-specific degradation. In Saccharomyces cerevisiae, a single decapping enzyme composed of a regulatory subunit (Dcp1) and a catalytic subunit (Dcp2) targets thousands of distinct substrate mRNAs.
He, Feng, Jacobson, Allan
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The role of transcriptional ‘futile cycles’ in autophagy and microbial pathogenesis
Microbial Cell, 2015 Eukaryotic cells utilize macroautophagy (hereafter autophagy) to recycle cellular materials during nutrient stress. Target of rapamycin (Tor) is a central regulator of this process, acting by post-translational mechanisms, phosphorylating ...
Guowu Hu +13 more
doaj +1 more source
Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal
Genes to Cells, 2017 mRNA degradation is a fundamental biological process that erases transcribed genetic information from cells. During maternal‐to‐zygotic transition of animal development, thousands of maternal mRNAs are degraded by multiple mechanisms including microRNAs and codon‐mediated decay. Enzymatic requirements for maternal mRNA clearance, however, are not fully
Yuichiro Mishima, Yukihide Tomari
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FEBS Letters, Volume 600, Issue 17, Page 2579-2614, September 2026.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Upf1 and Dcp2 interact in a manner dependent upon Edc3.
, 2013 (A) Upf1 was assessed for its ability to interact by yeast two-hybrid analysis with different domains of Dcp2. (B) The Dcp2-Upf1 interaction was further characterized by yeast two-hybrid analysis at the amino acid level. The structure of S.
Roy Parker (315449) +1 more
core +1 more source
Eukaryotic mRNA Decapping Activation
Frontiers in Genetics, 2022 The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation.
Elva Vidya +3 more
doaj +1 more source
A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing [PDF]
RNA, 2005 In eukaryotic cells degradation of bulk mRNA in the 5′ to 3′ direction requires the consecutive action of the decapping complex (consisting of DCP1 and DCP2) and the 5′ to 3′ exonuclease XRN1. These enzymes are found in discrete cytoplasmic foci known as P-bodies or GW-bodies (because of the accumulation of the GW182 antigen ...
Rehwinkel, Jan +3 more
openaire +4 more sources