Results 71 to 80 of about 3,123 (186)

A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

eLife, 2020
P bodies are archetypal biomolecular condensates that concentrate proteins and RNA without a surrounding membrane. While dozens of P body proteins are known, the concentrations of components in the compartment have not been measured.
Wenmin Xing, Denise Muhlrad, Roy Parker, Michael K Rosen   +3 more
doaj   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, Volume 13, Issue 48, 28 August 2026.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Study of the Biodegradation Properties of Amorphous Blends of Poly(Lactic Acid) and Poly(3‐Hydroxybutyrate‐co‐4‐Hydroxybutyrate) Foamed With Supercritical CO2

Macromolecular Materials and Engineering, Volume 311, Issue 8, August 2026.
Supercritical CO2 foaming of fully amorphous PLA/PHA blends produced low‐density closed‐cell foams with fine cellular morphology. Blending with PHA enhanced biodegradation under simulated home‐composting conditions, achieving up to 84% mass loss after 4 months, whereas marine degradation remained limited and was mainly restricted to the PHA component ...
Matteo Calosi, Marcel Dippold, Andrea D'Iorio, Elena Buratti, Holger Ruckdäschel, Monica Bertoldo   +5 more
wiley   +1 more source

Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation

Frontiers in Genetics, 2023
In eukaryotic cells, the synthesis, processing, and degradation of mRNA are important processes required for the accurate execution of gene expression programmes.
Qi Zhao, Lorenzo Pavanello, Mark Bartlam, Gerlof Sebastiaan Winkler   +3 more
doaj   +1 more source

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

BV1 interacts with AS2 and DCP2

, 2015
(A) Sub-cellular localization of AS2-EGFP fusion protein expressed from a native AS2 promoter in transgenic Arabidopsis root. Propidiumiodide (PI) was used to stain the nucleus and plant cell wall. Note cytoplasmic AS2 bodies. Bar: 10μm.
Yanwei Sun (117864), Pingzhi Zhao (802946), Rongxiang Fang (531674), Jing Qu (30904), Junyi Yang (602557), Shiqiang Gao (802947), Choonkyun Jung (279417), Jian Ye (19265), Nam-Hai Chua (3223)   +8 more
core   +1 more source

Механізми дії цитоплазматичних мікроРНК. Частина 4. Рекрутинг декепінгового комплексу DCP1-DCP2. Механізми остаточної деградації мРНК [PDF]

, 2022
У науковому огляді наведено механізми дії цитоплазматичних мікроРНК, а саме посттранскрипційний сайленсинг: рекрутинг декепінгового комплексу DCP1-DCP2 і порушення взаємодії мРНК з рибосомами.
Абатуров, О.Є., Бабич, В.Л.   +1 more
core   +1 more source

Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs

WIREs RNA, Volume 17, Issue 4, July/August 2026.
NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind, Samira K. Bell, Carol S. Lutz   +2 more
wiley   +1 more source

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif [PDF]

The EMBO Journal, 1999
The major pathway of mRNA degradation in yeast occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. To identify proteins that control the activity of the decapping enzyme, which is encoded by the DCP1 gene, we isolated a high-copy suppressor of the temperature-sensitive dcp1-2 allele, termed DCP2.
T, Dunckley, R, Parker
openaire   +2 more sources

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source