Results 181 to 190 of about 83,086 (267)

The Yin-Yang balance of SIRT1 and SIRT2 in cancer metabolic remodeling. [PDF]

Int J Biol Sci
Yi F, Shen L, Yang X, Wang Z, Li X, Shen Z, Liu W, Miao Q, Jiang S, Kong E, Song X, Zhou T, Bai N, Cao L.   +13 more
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Stearoyl-CoA Desaturase-1 Drives Tumor Growth by Interacting With Histone Deacetylase-2 and Deacetylating Nucleophosmin-1. [PDF]

MedComm (2020)
Wery C, Montero-Ruiz L, Bonneil E, Farran M, Jehay R, Garfia QH, Fettweis G, Blacher S, Pottier C, Cobraiville G, Boumahd Y, Peulen O, Noël A, Dequiedt F, Fillet M, Sounni NE.   +15 more
europepmc   +1 more source

FGF21/sirtuin 1 axis mediates the cardioprotective effects of high‐intensity interval training against doxorubicin‐induced cardiotoxicity by reducing inflammatory and oxidative stress

Experimental Physiology, EarlyView.
Abstract Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent, but its clinical use is limited by cumulative cardiotoxicity. Exercise, particularly high‐intensity interval training (HIIT), has emerged as an effective non‐pharmacological strategy to counteract chemotherapy‐induced cardiac injury.
Mahdiyeh Farahani, Abbas Ali Gaeini, Alireza Ghardashi Afousi, Mahboobeh Borjian Fard   +3 more
wiley   +1 more source

Retraction: The intra-nuclear SphK2-S1P axis facilitates M1-to-M2 shift of microglia via suppressing HDAC1-mediated KLF4 deacetylation. [PDF]

Front Immunol
Frontiers Editorial Office.
europepmc   +1 more source

Sirtuin signalling governs calcium homeostasis and mitochondrial function in metabolic syndrome cardiomyocytes

Experimental Physiology, EarlyView.
Abstract Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca2+ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these alterations remain incompletely defined.
Firat Akat, Leila Aryan, Suatnur Şık, Erkan Tuncay   +3 more
wiley   +1 more source

Melatonin Suppresses NLRP3 Inflammasome Activation via SIRT1-Mediated ETS1 Deacetylation to Attenuate LPS-Induced Pyroptosis in Alveolar Epithelial Cells. [PDF]

J Inflamm Res
He F, Liu C, Yu Y, Wang Q, Li L, Chao X, Chen L, Yu C.   +7 more
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Metabolic and post-translational modifications in sepsis-associated immune dysfunction: a conceptual framework. [PDF]

Front Immunol
Xu M, Zhang Z, Zhu M, Zhang S, Deng J, Du Z, Wang Z, Zhao H, Qiu Z.   +8 more
europepmc   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source