Results 201 to 210 of about 97,756 (253)

The epigenetic landscape of skeletal muscle in response to exercise and aging

open access: yesThe FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

open access: yesThe FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch   +7 more
wiley   +1 more source

High Molecular Weight Chitosan from Shrimp Shells: Synthesis of <i>Para</i>-Substituted Schiff Bases with Selective Leishmanicidal Activity and Application in CO<sub>2</sub>/O<sub>2</sub>-Selective Films. [PDF]

open access: yesPolymers (Basel)
Yánez-Crespo AA   +9 more
europepmc   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

open access: yesThe FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey   +2 more
wiley   +1 more source

Factors Determining Sirtuin-1 Target Engagement. [PDF]

open access: yesAdv Biol (Weinh)
Neumann-Staubitz P   +3 more
europepmc   +1 more source

Benign by design: A paradigm shift in cosmetic ingredient development

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Benign by design strategies enable the creation of biodegradable cosmetic ingredients, reducing environmental persistence while maintaining the intended biological activity. This work compiles design rules and tools to guide the development of more sustainable molecules for the cosmetics industry.
Sandra Mota   +3 more
wiley   +1 more source

TaHDA1‐mediated histone and non‐histone deacetylation orchestrates drought tolerance in wheat

open access: yesJournal of Integrative Plant Biology, EarlyView.
The histone deacetylase TaHDA1 is a key regulator linking histone and non‐histone deacetylation with drought adaptation and a potential target for improving drought resilience and grain nutritional quality in wheat. ABSTRACT Drought stress severely constrains wheat (Triticum aestivum L.) growth and productivity.
Jinpeng Li   +21 more
wiley   +1 more source

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