Results 191 to 200 of about 128,901 (311)

MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling. [PDF]

J Clin Invest
Sesay F, Zhang H, Kapoor-Vazirani P, Jung AT, Essien ME, Bastien AJ, Luong NC, Liu X, Head PE, Duong DM, Yang X, Buchwald ZS, Deng X, Seyfried NT, Yu DS.   +14 more
europepmc   +1 more source

Tetrazine Functionalized Graphene Enables Capture of Ultra‐Low Concentrations of Biomacromolecules

Small, EarlyView.
A novel method for covalent modification of monolayer graphene utilizing tetrazine containing diazonium salt is demonstrated. The modified graphene bearing tetrazine moieties undergoes inverse electron demand Diels‐Alder reactions with trans‐cyclooctene‐linked molecules, enabling bioorthogonal attachment of nanobodies that selectively capture EGFP ...
Ravindra K. Gupta, Hanbin Jeong, April Goehring, Eric Gouaux, Maggie He   +4 more
wiley   +1 more source

Histone Deacetylase 19 Controls Powdery Mildew Susceptibility by Attenuating Biosynthesis of Cuticular Wax and Salicylic Acid. [PDF]

J Fungi (Basel)
Zhang M, Zhao W, Zhi P, Li H, Chang C.
europepmc   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Role of HDAC6 in carcinomas. [PDF]

Discov Oncol
Chen P, Zhang YL.
europepmc   +1 more source

HDACs deacetylate histones

Reactome - a curated knowledgebase of biological pathways, 2014
openaire   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Lead Optimization: Synthesis and Biological Evaluation of Griseofulvin Derivatives as Novel SIRT6 Activators. [PDF]

ACS Med Chem Lett
Zorko T, Kogovšek J, Ciber L, Ostojić I, Maraš N, Novinec M, Štefane B.   +6 more
europepmc   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

Apigenin Suppresses Bladder Cancer via the SIRT6-NCOA2-PPARα Axis. [PDF]

Int J Biol Sci
Liu Y, Shi ZD, Wei YF, Jiang SY, Patel H, Liu QZ, Dong Y, Liu YF, Hao L, Gao S, Yang DH, Li Q, Han CH.   +12 more
europepmc   +1 more source