Results 171 to 180 of about 6,008 (204)

Concerted action of ataxin-2 and PABPC1-bound mRNA poly(A) tail in the formation of stress granules. [PDF]

Nucleic Acids Res
Yamagishi R, Inagaki H, Suzuki J, Hosoda N, Sugiyama H, Tomita K, Hotta T, Hoshino SI.   +7 more
europepmc   +1 more source

YTHDF2 suppresses the 2C-like state in mouse embryonic stem cells via the DUX-ZSCAN4 molecular circuit. [PDF]

J Biol Chem
Wu X, Cai W, He J, Zhang S, Wang S, Huang L, Zhang H, Sun X, Zhou J, Liu XM.   +9 more
europepmc   +1 more source

The Regulatory Role of m⁶A Modification in the Function and Signaling Pathways of Animal Stem Cells. [PDF]

Cells
Yang X, Xu Y, Zhu S, Wang M, Cao H, Lu L.   +5 more
europepmc   +1 more source

Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes. [PDF]

J Inflamm Res
Yamaguchi T, Ozawa R, Minato T, Hoshizaki M, Kammura Y, Okawara K, Khalil YA, Nakamura M, Yamaura K, Fukuda M, Imai Y, Kuba K.   +11 more
europepmc   +1 more source

Poly(A) variants supporting robust transmission stability in bacteria and high protein expression in animals for mRNA <i>in vitro</i> transcription. [PDF]

Mol Ther Nucleic Acids
Chen H, Qin W, Bao H, Chen X, Ye X, Wang Y, Liu L, Zhang Y, Sun Y, Zhang T, Dong Y, Cen S, Zhang W.   +12 more
europepmc   +1 more source

USB1 is a miRNA deadenylase that regulates hematopoietic development

Science, 2023
Mutations in the 3′ to 5′ RNA exonuclease USB1 cause hematopoietic failure in poikiloderma with neutropenia (PN). Although USB1 is known to regulate U6 small nuclear RNA maturation, the molecular mechanism underlying PN remains undetermined, as pre-mRNA splicing is unaffected in patients.
Ho-Chang Jeong, Siddharth Shukla, Wilson Chun Yim Fok   +2 more
exaly   +3 more sources

Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase

Cell, 2019
The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail.
Ingmar B Schäfer, Jan Michael Schuller, Mike Strauss   +2 more
exaly   +2 more sources

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Multifunctional deadenylase complexes diversify mRNA control

Nature Reviews Molecular Cell Biology, 2008
Dynamic changes of the lengths of mRNA poly(A) tails are catalysed by diverse deadenylase enzymes. Modulating the length of the poly(A) tail of an mRNA is a widespread means of controlling protein production and mRNA stability. Recent insights illuminate the specialized activities, biological functions and regulation of deadenylases.
Aaron C Goldstrohm, Marvin Wickens
exaly   +3 more sources

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets [PDF]

Molecular Cell, 2011
miRNAs are posttranscriptional regulators of gene expression that associate with Argonaute and GW182 proteins to repress translation and/or promote mRNA degradation. miRNA-mediated mRNA degradation is initiated by deadenylation, although it is not known whether deadenylases are recruited to the mRNA target directly or by default, as a consequence of a ...
Joerg E Braun, Eric Huntzinger, Elisa Izaurralde   +2 more
exaly   +4 more sources