Results 31 to 40 of about 243 (115)
DECAPS: Detail-Oriented Capsule Networks [PDF]
, 2020 Capsule Networks (CapsNets) have demonstrated to be a promising alternative to Convolutional Neural Networks (CNNs). However, they often fall short of state-of-the-art accuracies on large-scale high-dimensional datasets. We propose a Detail-Oriented Capsule Network (DECAPS) that combines the strength of CapsNets with several novel techniques to boost ...
Mobiny, Aryan +3 more
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A unique mRNA decapping complex in trypanosomes
Nucleic Acids Research, 2023 AbstractRemoval of the mRNA 5′ cap primes transcripts for degradation and is central for regulating gene expression in eukaryotes. The canonical decapping enzyme Dcp2 is stringently controlled by assembly into a dynamic multi-protein complex together with the 5′-3′exoribonuclease Xrn1.
Susanne Kramer +16 more
openaire +5 more sources
The NBDY Microprotein Regulates Cellular RNA Decapping [PDF]
Biochemistry, 2020 Proteogenomic identification of translated small open reading frames in humans has revealed thousands of microproteins, or polypeptides of fewer than 100 amino acids, that were previously invisible to geneticists. Hundreds of microproteins have been shown to be essential for cell growth and proliferation, and many regulate macromolecular complexes. One
Zhenkun Na +8 more
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Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity [PDF]
Molecular and Cellular Biology, 2015 mRNA decapping is a central step in eukaryotic mRNA decay that simultaneously shuts down translation initiation and activates mRNA degradation. A major complex responsible for decapping consists of the decapping enzyme Dcp2 in association with decapping enhancers.
Erickson, Stacy L +6 more
openaire +4 more sources
Investigation of IRES Insertion into the Genome of Recombinant MVA as a Translation Enhancer in the Context of Transcript Decapping. [PDF]
PLoS ONE, 2015 Recombinant modified vaccinia virus Ankara (MVA) has been used to deliver vaccine candidate antigens against infectious diseases and cancer. MVA is a potent viral vector for inducing high magnitudes of antigen-specific CD8+ T cells; however the cellular ...
Naif Khalaf Alharbi +3 more
doaj +1 more source
mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection
Molecular Plant-Microbe Interactions, 2022 Turnip mosaic virus is a devastating potyvirus infecting many economically important brassica crops. In response to this, the plant host engages its RNA silencing machinery, involving AGO proteins, as a prominent strategy to restrain turnip mosaic virus (
Zhangli Zuo +3 more
doaj +1 more source
The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay. [PDF]
PLoS ONE, 2012 Sequence-specific RNA binding proteins can induce the degradation of mRNAs through their ability to recruit proteins that trigger transcript destabilization. For example, Vts1p, the S.
Laura M Rendl +3 more
doaj +1 more source
Functional analysis of mRNA scavenger decapping enzymes [PDF]
RNA, 2004 Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNA. Two major decapping enzymes have been identified. The hDcp2 protein catalyzes hydrolysis of the 5′ cap linked to an RNA moiety, whereas the scavenger decapping enzyme, DcpS, functions on a cap structure lacking the RNA moiety.
Shin-Wu, Liu +5 more
openaire +2 more sources
Arabidopsis thaliana NudiXes have RNA-decapping activity
RSC Chemical Biology, 2023 In light of recent discoveries of noncanonical RNA caps, we studied substrate specificity of potential plant RNA decapping enzymes - NudiXes. We have found that some are very selective, while others function as general RNA decapping enzymes.
Maria-Bianca Mititelu +7 more
openaire +2 more sources
The Mimivirus L375 Nudix enzyme hydrolyzes the 5' mRNA cap.
PLoS ONE, 2021 The giant Mimivirus is a member of the nucleocytoplasmic large DNA viruses (NCLDV), a group of diverse viruses that contain double-stranded DNA (dsDNA) genomes that replicate primarily in eukaryotic hosts.
Grace Kago, Susan Parrish
doaj +1 more source