Results 51 to 60 of about 243 (115)

mRNA Decapping and 5′-3′ Decay Contribute to the Regulation of ABA Signaling in Arabidopsis thaliana

Frontiers in Plant Science, 2018
Defects in RNA processing and degradation pathways often lead to developmental abnormalities, impaired hormonal signaling and altered resistance to abiotic and biotic stress.
Izabela Wawer, Anna Golisz, Aleksandra Sulkowska, Dorota Kawa, Anna Kulik, Joanna Kufel   +5 more
doaj   +1 more source

Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

eLife
The mRNA 5'-cap structure removal by the decapping enzyme DCP2 is a critical step in gene regulation. While DCP2 is the catalytic subunit in the decapping complex, its activity is strongly enhanced by multiple factors, particularly DCP1, which is the ...
Ting-Wen Chen, Hsiao-Wei Liao, Michelle Noble, Jing-Yi Siao, Yu-Hsuan Cheng, Wei-Chung Chiang, Yi-Tzu Lo, Chung-Te Chang   +7 more
doaj   +1 more source

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria

Nature Communications, 2023
This study offers molecular insight into the sialidase and fucosidase decapping apparatus that initiates growth on mucin and promotes nutrient sharing by the dedicated mucolytic symbiont Akkermansia muciniphila with the mucus-associated microbiota.
Bashar Shuoker, Michael J. Pichler, Chunsheng Jin, Hiroka Sakanaka, Haiyang Wu, Ana Martínez Gascueña, Jining Liu, Tine Sofie Nielsen, Jan Holgersson, Eva Nordberg Karlsson, Nathalie Juge, Sebastian Meier, Jens Preben Morth, Niclas G. Karlsson, Maher Abou Hachem   +14 more
doaj   +1 more source

The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae

Biology Open, 2016
The rate and regulation of mRNA decay are major elements in the proper control of gene expression. Edc3 and Lsm4 are two decapping activator proteins that have previously been shown to function in the assembly of RNA granules termed P bodies.
Susanne Huch, Maren Müller, Mridula Muppavarapu, Jessie Gommlich, Vidya Balagopal, Tracy Nissan   +5 more
doaj   +1 more source

RNA degradation triggered by decapping is largely independent of initial deadenylation

The EMBO Journal
RNA stability, important for eukaryotic gene expression, is thought to depend on deadenylation rates, with shortened poly(A) tails triggering decapping and 5′ to 3′ degradation.
Léna Audebert, Frank Feuerbach, Mostafa Zedan, Alexandra P Schürch, Laurence Decourty, Abdelkader Namane, Emmanuelle Permal, Karsten Weis, Gwenaël Badis, Cosmin Saveanu   +9 more
doaj   +1 more source

Identification of NAD-RNA species and ADPR-RNA decapping in Archaea

Nature Communications, 2023
NAD is a coenzyme central to metabolism that also serves as a 5′-terminal cap for bacterial and eukaryotic transcripts. Thermal degradation of NAD can generate nicotinamide and ADP-ribose (ADPR).
José Vicente Gomes-Filho, Ruth Breuer, Hector Gabriel Morales-Filloy, Nadiia Pozhydaieva, Andreas Borst, Nicole Paczia, Jörg Soppa, Katharina Höfer, Andres Jäschke, Lennart Randau   +9 more
doaj   +1 more source

Multiple Nudix family proteins possess mRNA decapping activity [PDF]

RNA, 2013
RNA decapping is an important contributor to gene expression and is a critical determinant of mRNA decay. The recent demonstration that mammalian cells harbor at least two distinct decapping enzymes that preferentially modulate a subset of mRNAs raises the intriguing possibility of whether additional decapping enzymes exist.
Man-Gen, Song, Sophie, Bail, Megerditch, Kiledjian   +2 more
openaire   +2 more sources

Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus

Molecular Therapy: Oncolytics, 2018
Through the action of two virus-encoded decapping enzymes (D9 and D10) that remove protective caps from mRNA 5′-termini, Vaccinia virus (VACV) accelerates mRNA decay and limits activation of host defenses.
Hannah Burgess, Aldo Pourchet, Cristina H. Hajdu, Luis Chiriboga, Alan B. Frey, Ian Mohr   +5 more
doaj   +1 more source

Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

eLife
Degradation of many yeast mRNAs involves decapping by the Dcp1:Dcp2 complex. Previous studies on decapping activators Edc3 and Scd6 suggested their limited roles in mRNA decay.
Rakesh Kumar, Fan Zhang, Shreyas Niphadkar, Chisom Onu, Anil Kumar Vijjamarri, Miriam L Greenberg, Sunil Laxman, Alan G Hinnebusch   +7 more
doaj   +1 more source

The role of transcriptional ‘futile cycles’ in autophagy and microbial pathogenesis

Microbial Cell, 2015
Eukaryotic cells utilize macroautophagy (hereafter autophagy) to recycle cellular materials during nutrient stress. Target of rapamycin (Tor) is a central regulator of this process, acting by post-translational mechanisms, phosphorylating ...
Guowu Hu, Travis McQuiston, Amélie Bernard, Yoon-Dong Park, Jin Qiu, Ali Vural, Nannan Zhang, Scott R. Waterman, Nathan H. Blewett, Timothy G. Myers, John H. Kehrl, Gulbu Uzel, Daniel J. Klionsky, Peter R. Williamson   +13 more
doaj   +1 more source