Results 61 to 70 of about 243 (115)

User-Centric Approach to Specifying Technical Attributes of Drug Delivery Devices: Empirical Study of Autoinjector-Cap Removal Forces

Patient Preference and Adherence, 2021
Andreas Schneider,1 Philipp Richard,1 Philippe Mueller,1 Christoph Jordi,1 Mary Yovanoff,2 Jakob Lange1 1Ypsomed AG, Burgdorf, Switzerland; 2Design Science, Philadelphia, PA, USACorrespondence: Jakob LangeYpsomed AG, Brunnmattstrasse 6, Burgdorf 3401 ...
Schneider A, Richard P, Mueller P, Jordi C, Yovanoff M, Lange J   +5 more
doaj  

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Cell Reports, 2018
Summary: Aging is accompanied by a pervasive collapse of proteostasis, while reducing general protein synthesis promotes longevity across taxa. Here, we show that the eIF4E isoform IFE-2 is increasingly sequestered in mRNA processing (P) bodies during ...
Matthias Rieckher, Maria Markaki, Andrea Princz, Björn Schumacher, Nektarios Tavernarakis   +4 more
doaj   +1 more source

Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs

Cell Reports, 2019
Summary: RNA polymerase II transcripts receive a protective 5ʹ,5ʹ-triphosphate-linked 7-methylguanosine (m7G) cap, and its removal by decapping enzymes like DCP2 is critical for initiation of RNA decay.
Hao Wu, Lingyun Li, Kuan-Ming Chen, David Homolka, Pascal Gos, Fabienne Fleury-Olela, Andrew A. McCarthy, Ramesh S. Pillai   +7 more
doaj   +1 more source

CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA

Molecular Therapy: Nucleic Acids
Co-transcriptional capping allows exogenous mRNAs to yield robust protein expression. Identifying additional mRNA modifications that further boost protein output will be crucial for developing more efficacious mRNA therapies.
Zachary F. Mandell, Andrew Ujita, Jordana Henderson, Anthony Truong, Coleen Vo, Farinaz Rezvani, Nona Abolhassani, Alexandre Lebedev, Chunping Xu, Inna Koukhareva, Stephanie Ramos, Kate Broderick, Benjamin Hudson, Jeff Coller   +13 more
doaj   +1 more source

Identification of Cytoplasmic Capping Targets Reveals a Role for Cap Homeostasis in Translation and mRNA Stability

Cell Reports, 2012
The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was contradicted by the identification of capped transcripts missing portions of their 5′ ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this study,
Chandrama Mukherjee, Deepak P. Patil, Brian A. Kennedy, Baskar Bakthavachalu, Ralf Bundschuh, Daniel R. Schoenberg   +5 more
doaj   +1 more source

Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes.

PLoS ONE, 2013
BackgroundTurnover of mRNA is a critical step in the regulation of gene expression, and an important step in mRNA decay is removal of the 5' cap. We previously demonstrated that the expression of some immediate early gene mRNAs is controlled by RNA ...
Pei-Yu Chiang, Yu-Fang Shen, Yu-Lun Su, Ching-Han Kao, Nien-Yi Lin, Pang-Hung Hsu, Ming-Daw Tsai, Shun-Chang Wang, Geen-Dong Chang, Sheng-Chung Lee, Ching-Jin Chang   +10 more
doaj   +1 more source

Capping and Decapping Series of Boranes

International Journal of Chemistry, 2015
Whereas many of the capped series of carbonyl clusters of transition metals are known, those of corresponding borane series are unknown. These include the monocapped, bicapped, tricapped, tetracapped and so on. This paper attempts to correlate selected capped series of the carbonyl series with the hypothetical corresponding ones of boranes using 14n ...
openaire   +1 more source

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

ChemistryEurope
Dinucleoside tetraphosphates (Np4N) have been reported as 5′ caps of RNAs in bacteria and mammalian cells. The guanosine‐based version (Gp4N) resembles the canonical eukaryotic 5′ cap (m7Gp3N), which is a central platform for cap‐interacting proteins ...
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister   +5 more
doaj   +1 more source

Creatine mitigates neurogenesis impairment caused by defective DcpS decapping

Scientific Reports
Biallelic mutations in the DCPS gene disrupting the decapping activity of the scavenger decapping protein DcpS, leads to neurodevelopmental deficiencies and intellectual disability.
Jun Yang, Geeta Palsule, Xinfu Jiao, Jaime S. Messenger, Ronald P. Hart, Megerditch Kiledjian   +5 more
doaj   +1 more source

Family-wide analysis of human macrodomains reveals novel activities and identifies PARG as most efficient ADPr-RNA hydrolase

Communications Biology
ADP-ribosylation is well-known as protein posttranslational modification and was recently also identified as RNA posttranscriptional modification. When macrodomain proteins were identified as protein ADP-ribosylhydrolases, several ADP-ribosylation ...
Lisa Weixler, Roko Žaja, Nonso J. Ikenga, Jonas Siefert, Ganga Mohan, Gülcan Aydin, Sven Wijngaarden, Dmitri V. Filippov, Bernhard Lüscher, Karla L. H. Feijs-Žaja   +9 more
doaj   +1 more source