Results 1 to 10 of about 42,345 (132)
Exploring the therapeutic potential of recombinant bovine β-defensins for antimicrobial and anti-inflammatory functions in sepsis management [PDF]
Veterinary Researchβ-defensins are multifunctional peptides of the host immune system involved in responses to infectious diseases. We investigated the potential of five recombinant proteins based on bovine β-defensins (bovine neutrophil β-defensins (BNBD) 1, 2, 3, and 4 ...
Cristina Saubi +7 more
doaj +2 more sources
Snake venom defensins: Defining the structural and functional characteristics of the toxin family [PDF]
Journal of Structural Biology: XSnake venom defensins are a toxin family found in rattlesnake venoms (Crotalus) which are comprised of crotamine-like peptides and myotoxins. Their tertiary structure resembles the β-defensin family structure.
David Melendez-Martinez +7 more
doaj +2 more sources
Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease. [PDF]
, 2013 Dry eye disease can cause ocular surface inflammation that disrupts the corneal epithelial barrier. While dry eye patients are known to have an increased risk of corneal infection, it is not known whether there is a direct causal relationship between ...
Evans, David +4 more
core +25 more sources
In-Silico Tool for Predicting, Scanning, and Designing Defensins
Frontiers in Immunology, 2021 Defensins are host defense peptides present in nearly all living species, which play a crucial role in innate immunity. These peptides provide protection to the host, either by killing microbes directly or indirectly by activating the immune system.
Dilraj Kaur +5 more
doaj +1 more source
Defensins as a promising class of tick antimicrobial peptides: a scoping review
Infectious Diseases of Poverty, 2022 Background Ticks are hematophagous parasites that transmit an extensive range of pathogens to their vertebrate hosts. Ticks can destroy invading microorganisms or alleviate infection via their rudimentary but orchestrated innate immune system ...
Jiahui Wu +9 more
doaj +1 more source
Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing. [PDF]
PLoS ONE, 2017 Human α and β-defensins are cationic antimicrobial peptides characterized by three disulfide bonds with a triple stranded β-sheet motif. It is presumed that interaction with the bacterial cell surface and membrane permeabilization by defensins is an ...
Basil Mathew, Ramakrishnan Nagaraj
doaj +1 more source
An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]
, 2020 beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip +8 more
core +2 more sources
International Journal of Infectious Diseases, 2023 Objectives: Nosocomial ventriculitis is a difficult infectious condition to diagnose given that typical cerebral spinal fluid (CSF) parameters, commonly used in the diagnosis of meningitis, lack sensitivity and specificity in nosocomial ventriculitis ...
James B. Doub
doaj +1 more source
Respiratory Research, 2023 Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder associated with a 5–tenfold decrease in lung levels of alpha-1-antitrypsin (AAT) and an increased risk for obstructive lung disease.
Jungnam Lee +5 more
doaj +1 more source
Microbiology Spectrum, 2023 The intestinal microbiota is at the interface between the host and its environment and thus under constant exposure to host-derived and external modulators.
Fabiola Puértolas-Balint +1 more
doaj +1 more source