Results 161 to 170 of about 4,051 (196)

Biallelic mutations in SUPV3L1 cause an inherited neurodevelopmental disorder with variable leukodystrophy due to aberrant mitochondrial double stranded RNA processing

open access: yes
Green L   +50 more
europepmc   +1 more source

The social fabric of the RNA degradosome

open access: yesBiochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2013
Bacterial transcripts each have a characteristic half-life, suggesting that the processes of RNA degradation work in an active and selective manner. Moreover, the processes are well controlled, thereby ensuring that degradation is orderly and coordinated.
Marie Bouvier   +2 more
exaly   +3 more sources

Crystal structure of the Escherichia coli RNA degradosome component enolase [PDF]

open access: yesJournal of Molecular Biology, 2001
The crystal structure of Escherichia coli enolase (EC 4.2.1.11, phosphopyruvate hydratase), which is a component of the RNA degradosome, has been determined at 2.5 A. There are four molecules in the asymmetric unit of the C2 cell, and in one of the molecules, flexible loops close onto the active site.
Ben F Luisi
exaly   +4 more sources
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Recognition of Enolase in the Escherichia coli RNA Degradosome

Journal of Molecular Biology, 2006
In Escherichia coli, the glycolytic enzyme enolase is a component of the RNA degradosome, which is an RNase E mediated assembly involved in RNA processing and transcript turnover. The recruitment of enolase by the RNA degradosome has been implicated in the turnover of certain transcripts, and it is mediated by a small segment of roughly a dozen ...
Ben F Luisi
exaly   +3 more sources

Dynamics of the canonical RNA degradosome components during glucose stress

Biochimie, 2021
The RNA Degradosome (RNAD) is a multi-enzyme complex, which performs important functions in post-transcriptional regulation in Escherichia coli with the assistance of regulatory sRNAs and the RNA chaperone Hfq. Although the interaction of the canonical RNAD components with RNase E has been extensively studied, the dynamic nature of the interactions in ...
Marcos Emmanuel Jaso-Vera   +3 more
openaire   +2 more sources

The Structure and Function of the Gram-Positive Bacterial RNA Degradosome [PDF]

open access: yesFrontiers in Microbiology, 2017
The RNA degradosome is a highly structured protein complex responsible for bulk RNA decay in bacteria. The main components of the complex, ribonucleases, an RNA helicase, and glycolytic enzymes are well-conserved in bacteria. Some components of the degradosome are essential for growth and the disruption of degradosome formation causes slower growth ...
Kyu Hong Cho
exaly   +3 more sources

A DEAD-box RNA helicase in the Escherichia coli RNA degradosome

Nature, 1996
The Escherichia coli RNA degradosome is a multi-enzyme complex that contains the exoribonuclease polynucleotide phosphorylase (PNPase) and the endoribonuclease RNase E. Both enzymes are important in RNA processing and messenger RNA degradation. Here we report that enolase and RhlB are two other major components of the degradosome.
Agamemnon J Carpousis
exaly   +3 more sources

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