Results 11 to 20 of about 2,784 (175)

Formation of a membraneless compartment regulates bacterial virulence [PDF]

Nature Communications
The RNA-binding protein CsrA regulates the expression of hundreds of genes in several bacterial species, thus controlling virulence and other processes.
Lior Aroeti, Netanel Elbaz, Raya Faigenbaum-Romm, Oren Yakovian, Yael Altuvia, Liron Argaman, Naama Katsowich, Michal Bejerano-Sagie, Miriam Ravins, Hanah Margalit, Sigal Ben-Yehuda, Ilan Rosenshine   +11 more
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Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome

eLife, 2016
In all domains of life, the catalysed degradation of RNA facilitates rapid adaptation to changing environmental conditions, while destruction of foreign RNA is an important mechanism to prevent host infection.
An Van den Bossche, Steven W Hardwick, Pieter-Jan Ceyssens, Hanne Hendrix, Marleen Voet, Tom Dendooven, Katarzyna J Bandyra, Marc De Maeyer, Abram Aertsen, Jean-Paul Noben, Ben F Luisi, Rob Lavigne   +11 more
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α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies [PDF]

Molecular Cell, 2018
Ribonucleoprotein (RNP) granules play an important role in organizing eukaryotic mRNA metabolism via liquid-liquid phase separation (LLPS) of mRNA decay factors into membrane-less organelles in the cytoplasm. Here we show that the bacterium Caulobacter crescentus Ribonuclease (RNase) E assembles RNP LLPS condensates that we term bacterial RNP-bodies ...
Nadra Al-Husini, Dylan T. Tomares, Obaidah Bitar, W. Seth Childers, Jared M. Schrader   +4 more
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Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay [PDF]

Nature Communications
Metazoan histone mRNAs are a unique class of mRNAs that lack the poly(A) tail present in all other eukaryotic transcripts. Instead, they end in a conserved stem-loop (SL) structure, necessitating a decay mechanism that is distinct from deadenylation ...
Alexandrina Machado de Amorim, Guangpu Xue, Wenxia He, Theresa Dittmers, Sarah Lewandowski, Cecilia Perez-Borrajero, Juliane Bethmann, Nevena Mateva, Clemens Krage, Vidhyadhar Nandana, Bernhard Loll, Tarek Hilal, Janosch Hennig, Henning Urlaub, William F. Marzluff, Sutapa Chakrabarti   +15 more
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Bacterial RNA Degradosomes: Molecular Machines under Tight Control [PDF]

Trends in Biochemical Sciences, 2019
Bacterial RNA degradosomes are multienzyme molecular machines that act as hubs for post-transcriptional regulation of gene expression. The ribonuclease activities of these complexes require tight regulation, as they are usually essential for cell survival while potentially destructive.
Alejandro Tejada-Arranz, Valérie de Crécy‐Lagard, Hilde De Reuse   +2 more
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Multi‐scale ensemble properties of the Escherichia coli RNA degradosome [PDF]

Molecular Microbiology, 2021
AbstractIn organisms from all domains of life, multi‐enzyme assemblies play central roles in defining transcript lifetimes and facilitating RNA‐mediated regulation of gene expression. An assembly dedicated to such roles, known as the RNA degradosome, is found amongst bacteria from highly diverse lineages.
Tom Dendooven, Giulia Paris, Alexander V. Shkumatov, Md. Saiful Islam, Alister Burt, Marta Anna Kubańska, Tai Yuchen Yang, Steven W. Hardwick, Ben F. Luisi   +8 more
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The social fabric of the RNA degradosome

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
Bacterial transcripts each have a characteristic half-life, suggesting that the processes of RNA degradation work in an active and selective manner. Moreover, the processes are well controlled, thereby ensuring that degradation is orderly and coordinated.
Katarzyna Bandyra, Marie Bouvier, Agamemnon J. Carpousis, Ben F. Luisi   +3 more
openalex   +3 more sources

An RNA degradosome assembly in Caulobacter crescentus [PDF]

Nucleic Acids Research, 2010
In many bacterial species, the multi-enzyme RNA degradosome assembly makes key contributions to RNA metabolism. Powering the turnover of RNA and the processing of structural precursors, the RNA degradosome has differential activities on a spectrum of transcripts and contributes to gene regulation at a global level.
Steven W. Hardwick, Vsf Chan, R. William Broadhurst, Ben F. Luisi   +3 more
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The proteomic response to mutants of the Escherichia coli RNA degradosome [PDF]

Molecular BioSystems, 2013
The Escherichia coli RNA degradosome recognizes and degrades RNA through the coordination of four main protein components, the endonuclease RNase E, the exonuclease PNPase, the RhlB helicase and the metabolic enzyme enolase. To help our understanding of the functions of the RNA degradosome, we quantified expression changes of >2300 proteins using mass ...
Li Zhou, Ang B. Zhang, Rong Wang, Edward M. Marcotte, Christine Vogel   +4 more
openalex   +4 more sources

Evidence for a degradosome‐like complex in the mitochondria of Trypanosoma brucei [PDF]

FEBS Letters, 2009
MINT‐7188074: SUV3 (genbank_protein_gi:XP_844349) physically interacts (MI:0914) with DSS1 (uniprotkb:Q38EM3) by anti tag co‐immunoprecipitation (MI:0007)
Jonelle L. Mattiacio, Laurie K. Read
openalex   +4 more sources