The social fabric of the RNA degradosome
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2013 Bacterial transcripts each have a characteristic half-life, suggesting that the processes of RNA degradation work in an active and selective manner. Moreover, the processes are well controlled, thereby ensuring that degradation is orderly and coordinated.
Katarzyna J Bandyra +2 more
exaly +6 more sources
The Structure and Function of the Gram-Positive Bacterial RNA Degradosome [PDF]
Frontiers in Microbiology, 2017 The RNA degradosome is a highly structured protein complex responsible for bulk RNA decay in bacteria. The main components of the complex, ribonucleases, an RNA helicase, and glycolytic enzymes are well-conserved in bacteria.
Kyu Hong Cho +1 more
exaly +4 more sources
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
Proceedings of the National Academy of Sciences, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
core +9 more sources
A type III-A CRISPR-Cas system employs degradosome nucleases to ensure robust immunity
eLife, 2019 CRISPR-Cas systems provide sequence-specific immunity against phages and mobile genetic elements using CRISPR-associated nucleases guided by short CRISPR RNAs (crRNAs).
Lucy Chou-Zheng, Asma Hatoum-Aslan
doaj +6 more sources
Impact of pseudouridylation, substrate fold, and degradosome organization on the endonuclease activity of RNase E [PDF]
RNA, 2021 The conserved endoribonuclease RNase E dominates the dynamic landscape of RNA metabolism and underpins control mediated by small regulatory RNAs in diverse bacterial species.
Md. Saiful Islam +4 more
semanticscholar +5 more sources
Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome [PDF]
eLife, 2016 In all domains of life, the catalysed degradation of RNA facilitates rapid adaptation to changing environmental conditions, while destruction of foreign RNA is an important mechanism to prevent host infection.
An Van den Bossche +11 more
doaj +5 more sources
A minimal bacterial RNase J-based degradosome is associated with translating ribosomes [PDF]
Nucleic Acids Research, 2012 Protein complexes directing messenger RNA (mRNA) degradation are present in all kingdoms of life. In Escherichia coli, mRNA degradation is performed by an RNA degradosome organized by the major ribonuclease RNase E.
Yulia Redko +7 more
semanticscholar +5 more sources
Towards Understanding Helicase and Chaperone Activities in the RNA Degradosome [PDF]
, 2020 The E. coli RNA degradosome is a complex multi-enzyme machine which is central to the post-transcriptional regulation of the cell. Some of its functions include maturing and processing sRNA, rRNA, and tRNA, as well as degrading mRNA.
Shen, Zi Ran
core +4 more sources
TheYersinia pseudotuberculosisdegradosome is required for oxidative stress, while its PNPase subunit plays a degradosome-independent role in cold growth [PDF]
FEMS Microbiology Letters, 2012 Yersinia polynucleotide phosphorylase (PNPase), a 3'-5' exoribonuclease, has been shown to affect growth during several stress responses. In Escherichia coli, PNPase is one of the subunits of a multiprotein complex known as the degradosome, but also has degradosome-independent functions. The carboxy-terminus of E.
Amanda Henry +3 more
semanticscholar +5 more sources
Molecular Microbiology, Volume 121, Issue 1, Page 40-52, January 2024., 2023 Here, we employ coelution experiments and far‐western blotting to identify stable interactions between the main components of the B. subtilis degradosome and the small proteins SR1P and SR7P. Our data indicate that B.
Inam ul Haq, P. Müller, S. Brantl
semanticscholar +2 more sources