The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogenStaphylococcus aureus [PDF]
RNA Biology, 2015 Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance.
Caroline Giraud +5 more
semanticscholar +4 more sources
Interplay between bacterial 5′-NAD-RNA decapping hydrolase NudC and DEAD-box RNA helicase CsdA in stress responses [PDF]
mSystems, 2023 Both prokaryotic and eukaryotic RNAs can be 5′-capped by the metabolite nicotinamide adenine dinucleotide (NAD). Nudix hydrolases, such as bacterial NudC, specifically remove NAD-caps; however, the molecular and cellular functions of these ...
Milda Mickutė +10 more
doaj +2 more sources
Involvement of RNase J in CRISPR RNA maturation and degradosome formation in cyanobacteria
bioRxivMany bacteria and archaea use CRISPR-Cas systems, which provide RNA-based, adaptive, and inheritable immune defenses against invading viruses and other foreign genetic elements. The proper processing of CRISPR guide RNAs (crRNAs) is a crucial step in the
Raphael Bilger +7 more
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Formation of a stable RNase Y-RicT (YaaT) complex requires RicA (YmcA) and RicF (YlbF) [PDF]
mBio, 2023 In Bacillus subtilis, the RicT (YaaT), RicA (YmcA), and RicF (YlbF) proteins, which form a stable ternary complex, are needed together with RNase Y (Rny) to cleave and thereby stabilize several key transcripts encoding enzymes of intermediary metabolism.
Eugenie Dubnau +2 more
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The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The cellular mechanisms governing tRNA stability in bacteria are not well understood, and in contrast to eukaryotes, a bacterial system for degradation of mature tRNAs has not been described.
Satoshi Kimura, Matthew K Waldor
exaly +2 more sources
Nucleic Acids Research, 2019 The phenotypic adjustments of Mycobacterium tuberculosis are commonly inferred from the analysis of transcript abundance. While mechanisms of transcriptional regulation have been extensively analysed in mycobacteria, little is known about mechanisms that
Przemysław Płociński +9 more
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Structural Insights into the Dimeric Form of Bacillus subtilis RNase Y Using NMR and AlphaFold [PDF]
Biomolecules, 2022 RNase Y is a crucial component of genetic translation, acting as the key enzyme initiating mRNA decay in many Gram-positive bacteria. The N-terminal domain of Bacillus subtilis RNase Y (Nter-BsRNaseY) is thought to interact with various protein partners ...
Nelly Morellet +4 more
doaj +2 more sources
Recognition of the 70S ribosome and polysome by the RNA degradosome in Escherichia coli [PDF]
Nucleic Acids Research, 2012 The RNA degradosome is a multi-enzyme assembly that contributes to key processes of RNA metabolism, and it engages numerous partners in serving its varied functional roles.
Yi-Chun Tsai +7 more
semanticscholar +5 more sources
Physical and functional interactions among RNase E, polynucleotide phosphorylase and the cold-shock protein, CsdA: evidence for a ‘cold shock degradosome’ [PDF]
Molecular Microbiology, 2004 Annie Prud’homme‐Généreux +5 more
exaly +2 more sources
Cyanobacterial RNA Helicase CrhR Localizes to the Thylakoid Membrane Region and Cosediments with Degradosome and Polysome Complexes in Synechocystis sp. Strain PCC 6803 [PDF]
Journal of Bacteriology, 2016 Albert Remus R. Rosana +3 more
openalex +2 more sources