Results 41 to 50 of about 2,784 (175)
Frontiers in Microbiology, 2019 Regulated RNA turnover is vital for the control of gene expression in all cellular life. In Escherichia coli, this process is largely controlled by a stable degradosome complex containing RNase E and a variety of additional enzymes.
Rong Mu +6 more
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Structural Insights into the Dimeric Form of Bacillus subtilis RNase Y Using NMR and AlphaFold
Biomolecules, 2022 RNase Y is a crucial component of genetic translation, acting as the key enzyme initiating mRNA decay in many Gram-positive bacteria. The N-terminal domain of Bacillus subtilis RNase Y (Nter-BsRNaseY) is thought to interact with various protein partners ...
Nelly Morellet +4 more
doaj +1 more source
Genes important for catalase activity in Enterococcus faecalis. [PDF]
PLoS ONE, 2012 Little in general is known about how heme proteins are assembled from their constituents in cells. The Gram-positive bacterium Enterococcus faecalis cannot synthesize heme and does not depend on it for growth.
Michael Baureder, Lars Hederstedt
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Inflammatory mitochondrial nucleic acids as drivers of pathophysiology
, 2023 Clinical and Translational Medicine, Volume 13, Issue 9, September 2023.
Christian G. Peace +2 more
wiley +1 more source
Critical roles for ‘housekeeping’ nucleases in type III CRISPR-Cas immunity
eLife, 2022 CRISPR-Cas systems are a family of adaptive immune systems that use small CRISPR RNAs (crRNAs) and CRISPR-associated (Cas) nucleases to protect prokaryotes from invading plasmids and viruses (i.e., phages).
Lucy Chou-Zheng, Asma Hatoum-Aslan
doaj +1 more source
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance R loops form during transcription when the mRNA hybridizes back to the template DNA forming a stable DNA–RNA hybrid. Stable R loops can block replication and transcription machineries, leading to genome instability and human diseases.
Silva, Sonia +2 more
openaire +6 more sources
mBio, 2018 Present in every kingdom of life, generally in multiple copies, DEAD-box RNA helicases are specialized enzymes that unwind RNA secondary structures. They play major roles in mRNA decay, ribosome biogenesis, and adaptation to cold temperatures.
Lamya El Mortaji +7 more
doaj +1 more source
Human RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processing. [PDF]
PLoS ONE, 2013 Mammalian RNase H1 has been implicated in mitochondrial DNA replication and RNA processing and is required for embryonic development. We identified the mitochondrial protein P32 that binds specifically to human RNase H1, but not human RNase H2. P32 binds
Hongjiang Wu +4 more
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SR7 – a dual-function antisense RNA from Bacillus subtilis
RNA Biology, 2021 Here, we describe SR7, a dual-function antisense RNA encoded on the Bacillus subtilis chromosome. This RNA was earlier described as SigB-dependent regulatory RNA S1136 and reported to reduce the amount of the small ribosomal subunit under ethanol stress.
Inam Ul Haq +2 more
doaj +1 more source
Characterization of Components of the Staphylococcus aureus mRNA Degradosome Holoenzyme-Like Complex [PDF]
Journal of Bacteriology, 2011 ABSTRACTBacterial two-hybrid analysis identified theStaphylococcus aureusRNA degradosome-like complex to include RNase J1, RNase J2, RNase Y, polynucleotide phosphorylase (PNPase), enolase, phosphofructokinase, and a DEAD box RNA helicase. Results also revealed that the recently recognized RNase RnpA interacts with theS. aureusdegradosome and that this
Christelle M. Roux +2 more
openalex +4 more sources