Results 51 to 60 of about 3,302 (208)

A minimal bacterial RNase J-based degradosome is associated with translating ribosomes [PDF]

Nucleic Acids Research, 2012
Protein complexes directing messenger RNA (mRNA) degradation are present in all kingdoms of life. In Escherichia coli, mRNA degradation is performed by an RNA degradosome organized by the major ribonuclease RNase E. In bacteria lacking RNase E, the existence of a functional RNA degradosome is still an open question.
Yulia Redko, Sylvie Aubert, Anna Stachowicz, Pascal Lenormand, Abdelkader Namane, Fabien Darfeuille, Marie Thibonnier, Hilde De Reuse   +7 more
openalex   +4 more sources

A eukaryotic-like 3′ untranslated region in Salmonella enterica hilD mRNA [PDF]

, 2014
Long 3' untranslated regions (3'UTRs) are common in eukaryotic mRNAs. In contrast, long 3'UTRs are rare in bacteria, and have not been characterized in detail.
Casadesús Pursals, Josep, López Garrido, Javier, Puerta Fernández, Elena   +2 more
core   +1 more source

Distinct co-evolution patterns of genes associated to DNA polymerase III DnaE and PolC

BMC Genomics, 2012
Background Bacterial genomes displaying a strong bias between the leading and the lagging strand of DNA replication encode two DNA polymerases III, DnaE and PolC, rather than a single one.
Engelen Stefan, Vallenet David, Médigue Claudine, Danchin Antoine   +3 more
doaj   +1 more source

Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in two siblings with a novel neurodegenerative syndrome

Journal of Inherited Metabolic Disease, Volume 45, Issue 2, Page 292-307, March 2022., 2022
Abstract SUPV3L1 encodes a helicase that is mainly localized in the mitochondria. It has been shown in vitro to possess both double‐stranded RNA and DNA unwinding activity that is ATP‐dependent. Here we report the first two patients for this gene who presented with a homozygous preliminary stop codon resulting in a C‐terminal truncation of the SUPV3L1 ...
Selma L. van Esveld, Richard J. Rodenburg, Fathiya Al‐Murshedi, Eiman Al‐Ajmi, Sana Al‐Zuhaibi, Martijn A. Huynen, Johannes N. Spelbrink   +6 more
wiley   +1 more source

Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA [PDF]

, 2002
We characterised the human hSuv3p protein belonging to the family of NTPases/helicases. In yeast mitochondria the hSUV3 orthologue is a component of the degradosome complex and participates in mtRNA turnover and processing, while in Caenorhabditis ...
Awiszus, K., Bartnik, E., Borowski, P., Dmochowska, A., Dziembowski, A., Minczuk, M., Papworth, M.A., Piwowarski, J., Schalinski, S., Stepien, P.P., Tokatlidis, K.   +10 more
core   +2 more sources

Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism

Nature Communications, 2023
Ribonucleases (RNases) are responsible for RNA metabolism. RNase J, the core enzyme of the RNA degradosome, plays an essential role in global mRNA decay.
Luyao Bao, Juan Hu, Bowen Zhan, Mingzhe Chi, Zhengyang Li, Sen Wang, Chan Shan, Zhaozhao Zhao, Yanchao Guo, Xiaoming Ding, Chaoneng Ji, Shengce Tao, Ting Ni, Xuelian Zhang, Guoping Zhao, Jixi Li   +15 more
doaj   +1 more source

Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]

, 2012
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Achim Schnaufer, Alatortsev, Ammerman, Aphasizheva, Aphasizheva, Bailey, Borst, Carnes, Carnes, Carnes, Cruz-Reyes, Cruz-Reyes, Deschamps, Ernst, Ernst, Etheridge, Fisk, Guo, Guo, Guo, Hashimi, Igo, Igo, Inoue, Jason Carnes, Jensen, Kao, Kenneth Stuart, Koslowsky, Koslowsky, Lukes, Mattiacio, Mattiacio, Melissa Lerch, Militello, Nathalie Acestor, Niemann, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Piller, Rigaut, Ryan, Sabatini, Schnaufer, Schnaufer, Seiwert, Simpson, Stuart, Trotter, Weng, Wirtz, Worthey, Xuemin Guo, Zhang   +58 more
core   +1 more source

Allosteric activation of RhlB by RNase E induces partial duplex opening in substrate RNA

Frontiers in Molecular Biosciences, 2023
The E. coli DEAD-Box helicase RhlB is responsible for ATP-dependent unwinding of structured mRNA to facilitate RNA degradation by the protein complex degradosome.
Heidi Zetzsche, Laura Raschke, Boris Fürtig   +2 more
doaj   +1 more source

Structural Insights into the Dimeric Form of Bacillus subtilis RNase Y Using NMR and AlphaFold

Biomolecules, 2022
RNase Y is a crucial component of genetic translation, acting as the key enzyme initiating mRNA decay in many Gram-positive bacteria. The N-terminal domain of Bacillus subtilis RNase Y (Nter-BsRNaseY) is thought to interact with various protein partners ...
Nelly Morellet, Pierre Hardouin, Nadine Assrir, Carine van Heijenoort, Béatrice Golinelli-Pimpaneau   +4 more
doaj   +1 more source

The first small-molecule inhibitors of members of the ribonuclease E family [PDF]

, 2015
The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression.
A Danchin, A Koul, AJ Callaghan, AJ Callaghan, AJ Callaghan, AJ Carpousis, AJ Carpousis, AP Walsh, AR Subramanian, BK Ghora, BK Mohanty, BK Shoichet, C Condon, C Condon, C Dye, CM Arraiano, D Apirion, D Suck, GA Mackie, JE Clarke, K Lee, KH Bleicher, KJ McDowall, KJ McDowall, L Kime, L Kime, M Kuwano, M Ono, M Wachi, MC Ow, MHJ Seifert, MJ Marcaida, N Guex, O Guner, O Zelenko, SM Garrey, SS Jourdan, V Khemici, VJ Gillet, VR Kaberdin, XQ Jiang, Y Redko, Z Zsoldos, ZW Li   +43 more
core   +4 more sources