Results 1 to 10 of about 62,898 (162)

Study on γδT-Cell Degranulation at Maternal–Fetal Interface via iKIR–HLA-C Axis [PDF]

Cells
Maternal–fetal tolerance mechanisms are crucial during human pregnancy to prevent the immune rejection of the embryo. A well-known mechanism blocking NK-cell cytotoxicity is the interaction of their inhibitory killer-cell immunoglobulin-like receptors ...
Diana Manchorova, Marina Alexandrova, Antonia Terzieva, Ivaylo Vangelov, Ljubomir Djerov, Iana Hristova, Gil Mor, Tanya Dimova   +7 more
doaj   +2 more sources

Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis

Frontiers in Immunology, 2020
Studies have endeavored to understand the cause for impaired antimicrobial killing by neutrophils of people with cystic fibrosis (PWCF). The aim of this study was to focus on the bacterial phagosome.
Mark P Murphy, Niall Browne, Karen Mcquillan   +2 more
exaly   +3 more sources

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

Frontiers in Immunology, 2021
Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive ...
Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li   +10 more
doaj   +1 more source

Cytoskeletal Transport, Reorganization, and Fusion Regulation in Mast Cell-Stimulus Secretion Coupling

Frontiers in Cell and Developmental Biology, 2021
Mast cells are well known for their role in allergies and many chronic inflammatory diseases. They release upon stimulation, e.g., via the IgE receptor, numerous bioactive compounds from cytoplasmic secretory granules. The regulation of granule secretion
Gaël Ménasché, Cyril Longé, Manuela Bratti, Manuela Bratti, Ulrich Blank, Ulrich Blank   +5 more
doaj   +1 more source

Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs

Frontiers in Pharmacology, 2021
Neutrophilic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), or psoriasis, exert a huge burden on the global health system due to the lack of safe and effective treatments. Volatile
Michal Korinek, Michal Korinek, Michal Korinek, Heba Handoussa, Yi-Hong Tsai, You-Ying Chen, Meng-Hua Chen, Zan-Wei Chiou, Yu Fang, Fang-Rong Chang, Chia-Hung Yen, Chung-Fan Hsieh, Bing-Hung Chen, Mohamed El-Shazly, Mohamed El-Shazly, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang   +18 more
doaj   +1 more source

Mast cell distribution around the needle tract following acupuncture in Zusanli (ST36) acupoint in rats [PDF]

Bulgarian Journal of Veterinary Medicine, 2019
The aim of this study was to investigate mast cell (MCs) distribution in the vicinity of the needle tract formed after acupuncture in Zusanli (ST36) acupoint in rats.
N. D. Dimitrov, D. Y. Atanasova, N. S. Tomov, Y. A. Staykova-Pirovska, I. G. Ivanova , D. P. Sivrev   +5 more
doaj   +1 more source

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria

Frontiers in Immunology, 2021
Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been ...
Mojca Bizjak, Mitja Košnik, Dorothea Terhorst-Molawi, Dejan Dinevski, Marcus Maurer   +4 more
doaj   +1 more source

Locked and Loaded: Mechanisms Regulating Natural Killer Cell Lytic Granule Biogenesis and Release

Frontiers in Immunology, 2022
NK cell-mediated cytotoxicity is a critical element of our immune system required for protection from microbial infections and cancer. NK cells bind to and eliminate infected or cancerous cells via direct secretion of cytotoxic molecules toward the bound
Hyoungjun Ham, Michael Medlyn, Daniel D. Billadeau, Daniel D. Billadeau   +3 more
doaj   +1 more source

Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection

Frontiers in Microbiology, 2022
Mast cells (MCs) are strategically located at the host-environment interface and their non-allergic roles in the immune-surveillance of pathogens have recently gained more attention.
Shu-Ting Song, Shu-Ting Song, Meng-Li Wu, Meng-Li Wu, Hai-Jiao Zhang, Xiao Su, Jian-Hua Wang, Jian-Hua Wang   +7 more
doaj   +1 more source

Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses

Frontiers in Immunology, 2022
Host defense against bacterial and fungal infections diminishes with age. In humans, impaired neutrophil responses are thought to contribute to this decline. However, it remains unclear whether neutrophil responses are also impaired in old mice. Here, we
Kirsti Hornigold, Julia Y. Chu, Stephen A. Chetwynd, Polly A. Machin, Laraine Crossland, Chiara Pantarelli, Karen E. Anderson, Phillip T. Hawkins, Anne Segonds-Pichon, David Oxley, Heidi C. E. Welch   +10 more
doaj   +1 more source