Results 131 to 140 of about 137,298 (386)

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Accepted Article.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify non‐invasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, The LN classification steering committee   +11 more
wiley   +1 more source

Eosinophil secretion of granule-derived cytokines

Frontiers in Immunology, 2014
Eosinophils are tissue-dwelling leukocytes, present in the thymus, and gastrointestinal and genitourinary tracts of healthy individuals at baseline, and recruited, often in large numbers, to allergic inflammatory foci and sites of active tissue repair ...
Lisa A Spencer, Kennedy eBonjour, Rossana C.N. Melo, Peter F. Weller   +3 more
doaj   +1 more source

Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome

Arthritis &Rheumatology, Accepted Article.
Background ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. Objective To evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired thrombo‐inflammatory ...
Bruna de Moraes Mazetto Fonseca, Somanathapura K. NaveenKumar, Srilakshmi Yalavarthi, Kavya Sugur, Thalia G. Newman, Claire K. Hoy, Cyrus Sarosh, Jordan K. Schaefer, Ajay Tambralli, Jacqueline A. Madison, Yu Zuo, Fernanda Orsi, Michael Holinstat, Jason S. Knight   +13 more
wiley   +1 more source

Unique compound with anti-allergic action: inhibition of Lyn kinase activity by KIRA6

Frontiers in Pharmacology
Mast cells and basophils play important roles in allergic disorders associated with specific antigens and IgE. Crosslinking of the high-affinity IgE receptor (FcεRI) by specific antigens activates several tyrosine kinases, such as Lyn and spleen ...
Goshi Matsushima, Yuri Matsui, Hanano Okamoto, Nagisa Umeda, Mai Kakimoto, Megumi Mino, Tadashi Nakagawa, Kaori Ishii, Yoshimi Matsuo, Daiki Matsubara, Akio Tanaka, Koji Ogata, Michiko Yoshii, Mitsuhiro Goda, Yuhki Yanase, Toru Hosoi, Koichiro Ozawa, Koichiro Ozawa   +17 more
doaj   +1 more source

CD155 on HIV-infected cells is not modulated by HIV-1 Vpu and Nef but synergizes with NKG2D ligands to trigger NK cell lysis of autologous primary HIV-infected cells [PDF]

, 2017
Activation of primary CD4(+) T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)].
Barker, Edward, Cogswell, Andrew, Davis, Zacharay B, Plannelles, Vincente, Sowriajan, Bharatwaj, Ward, Jeffrey P   +5 more
core   +2 more sources

Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting

Journal of Immunological Research, 2015
Neutrophils participate in the maintenance of host integrity by releasing various cytotoxic proteins during degranulation. Due to recent advances, a major role has been attributed to neutrophil-derived cytokine secretion in the initiation, exacerbation ...
Isabelle Naegelen, N. Beaume, S. Plançon, Véronique Schenten, E. Tschirhart, S. Bréchard   +5 more
semanticscholar   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Role of female sex hormones, estradiol and progesterone, in mast cell behaviour

Frontiers in Immunology, 2012
Female sex hormones have long been suspected to have an effect on mast cell (MC) behaviour. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different
Oliver eZierau, Ana Claudia Zenclussen, Federico eJensen   +2 more
doaj   +1 more source

Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1-Deficient Mice [PDF]

, 2019
Ciersten A. Burks, Steven D. Rhodes, Waylan Bessler, Shi Chen, Abbi E. Smith, Jeffrey R. Gehlhausen, Eric Hawley, Jiang Li, Xiaohong Li, Jin Yuan, Qingbo Lu, Max Jacobsen, George E. Sandusky, David R. Jones, D. Wade Clapp, Jaishri O. Blakeley   +15 more
openalex   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source