Results 11 to 20 of about 137,298 (386)
Piecemeal degranulation in human tumour pheochromocytes
Journal of Anatomy, 2005 AbstractPiecemeal degranulation (PMD) has been recognized in two cases of human pheochromocytoma from the adrenal medulla, which were studied by transmission electron microscopy. Tumour pheochromocytes presented a highly characteristic cytoplasmic admixture of normal resting granules, swollen granules with eroded matrices and enlarged empty containers.
Enrico Crivellato +3 more
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Degranulation deconstructed [PDF]
Journal of Clinical Investigation, 2012 Pediatricians first described the clinical features of chronic granulomatous disease (CGD) in 1959. Almost a decade later, in a collaborative effort that crossed disciplines, we participated in the discoveries that defined the cellular deficiencies of CGD, specifically finding that improper degranulation of leukocytes did not explain their failure to ...
Robert L, Baehner, Morris J, Karnovsky
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Metabolic Consequences of IgE- and Non-IgE–Mediated Mast Cell Degranulation
Journal of Immunology, 2021 Key Points Mast cell metabolism varies between IgE- and non-IgE–mediated degranulation. Non-IgE mast cell degranulation induces a stress response from metabolic insult.
Ryan P. Mendoza +4 more
semanticscholar +1 more source
Myeloid-Specific Pyruvate-Kinase-Type-M2-Deficient Mice Are Resistant to Acute Lung Injury
Biomedicines, 2022 Infiltration of polymorphonuclear neutrophils (PMNs) plays a central role in acute lung injury (ALI). The mechanisms governing PMN inflammatory responses, however, remain incompletely understood.
Xinlei Sun +7 more
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Locked and Loaded: Mechanisms Regulating Natural Killer Cell Lytic Granule Biogenesis and Release
Frontiers in Immunology, 2022 NK cell-mediated cytotoxicity is a critical element of our immune system required for protection from microbial infections and cancer. NK cells bind to and eliminate infected or cancerous cells via direct secretion of cytotoxic molecules toward the bound
Hyoungjun Ham +3 more
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Frontiers in Immunology, 2021 Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been ...
Mojca Bizjak +4 more
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Molecules, 2022 Atopic dermatitis (AD) is a chronic inflammatory dermal disease with symptoms that include inflammation, itching, and dry skin. 1-Iodohexadecane is known as a component of Chrysanthemum boreale essential oil that has an inhibitory effect on AD-like ...
Do Yoon Kim +5 more
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The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host
International Journal of Molecular Sciences, 2020 Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation and the release of ...
K. Lodge +3 more
semanticscholar +1 more source
Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy
Antioxidants, 2022 Neutrophils, the most abundant white blood cells in humans, are critical for host defense against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils can eradicate bacteria and clear debris.
Salma A. Rizo-Téllez +2 more
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DOCK2 Mutation and Recurrent Hemophagocytic Lymphohistiocytosis
Life, 2023 Hemophagocytic lymphohistiocytosis (HLH) is a syndrome resulting from uncontrolled hyper-inflammation, excessive immune system activation, and elevated levels of inflammatory cytokines.
Daniel D. Reiff +2 more
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