Results 11 to 20 of about 63,047 (307)
The Enigma of Eosinophil Degranulation [PDF]
International Journal of Molecular Sciences, 2021 Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis.
Timothée Fettrelet +4 more
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Degranulation deconstructed [PDF]
Journal of Clinical Investigation, 2012 Pediatricians first described the clinical features of chronic granulomatous disease (CGD) in 1959. Almost a decade later, in a collaborative effort that crossed disciplines, we participated in the discoveries that defined the cellular deficiencies of CGD, specifically finding that improper degranulation of leukocytes did not explain their failure to ...
Robert L, Baehner, Morris J, Karnovsky
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Neutrophil degranulation and myocardial infarction
Cell Communication and Signaling, 2022 AbstractMyocardial infarction (MI) is one of the most common cardiac emergencies with high morbidity and is a leading cause of death worldwide. Since MI could develop into a life-threatening emergency and could also seriously affect the life quality of patients, continuous efforts have been made to create an effective strategy to prevent the occurrence
Nan Zhang +4 more
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Degranulating Eosinophils in Human Endometriosis [PDF]
The American Journal of Pathology, 2000 Degranulating eosinophils have been described in most endometrial cancers. We hypothesized that endometriosis (ectopic, nonneoplastic endometrial tissue) would be an appropriate model system for determining whether eosinophil degranulation is part of a specific immune response to endometrial cancer or if it is related to the more general phenomenon of ...
Gloria Brown +5 more
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Molecules, 2022 Atopic dermatitis (AD) is a chronic inflammatory dermal disease with symptoms that include inflammation, itching, and dry skin. 1-Iodohexadecane is known as a component of Chrysanthemum boreale essential oil that has an inhibitory effect on AD-like ...
Do Yoon Kim +5 more
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Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy
Antioxidants, 2022 Neutrophils, the most abundant white blood cells in humans, are critical for host defense against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils can eradicate bacteria and clear debris.
Salma A. Rizo-Téllez +2 more
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Degranulation response in cytotoxic rat lymphocytes measured with a novel CD107a antibody
Frontiers in Immunology, 2016 Measuring degranulation through CD107a expression has become an advantageous tool for testing the functional capacity of cytotoxic cells. Such functional studies have been hampered in the rat by the lack of a suitable anti-rat CD107a antibody.
Amanda Sudworth +3 more
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Myeloid-Specific Pyruvate-Kinase-Type-M2-Deficient Mice Are Resistant to Acute Lung Injury
Biomedicines, 2022 Infiltration of polymorphonuclear neutrophils (PMNs) plays a central role in acute lung injury (ALI). The mechanisms governing PMN inflammatory responses, however, remain incompletely understood.
Xinlei Sun +7 more
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Pharmacology Research & Perspectives, 2020 Acute respiratory virus infections, such as influenza and RSV, are predominant causes of asthma exacerbations. Eosinophils act as a double‐edged sword in exacerbations in that they are activated by viral infections but also can capture and inactivate ...
Yanaika Shari Sabogal Piñeros +8 more
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Studies on the degranulation test for carcinogens [PDF]
FEBS Letters, 1983 The radiometric assay of degranulation of the hepatic endoplasmic reticulum by chemical carcinogens has been re‐examined. Both 1,2,3,4,‐ and 1,25,6‐dibenzanthracenes caused degranulation of rough membranes in vitro; with acetamidofluorenes and naphthylamines the carcinogenic analogues caused moderately greater degranulation.
Thomas W. Poole, Dennis V. Parke
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