Results 11 to 20 of about 116,525 (341)
Degranulation deconstructed [PDF]
Journal of Clinical Investigation, 2012 Pediatricians first described the clinical features of chronic granulomatous disease (CGD) in 1959. Almost a decade later, in a collaborative effort that crossed disciplines, we participated in the discoveries that defined the cellular deficiencies of CGD, specifically finding that improper degranulation of leukocytes did not explain their failure to ...
Robert L, Baehner, Morris J, Karnovsky
openaire +2 more sources
The Enigma of Eosinophil Degranulation [PDF]
International Journal of Molecular Sciences, 2021 Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis.
Timothée Fettrelet +4 more
openaire +3 more sources
Piecemeal degranulation in human tumour pheochromocytes
Journal of Anatomy, 2005 AbstractPiecemeal degranulation (PMD) has been recognized in two cases of human pheochromocytoma from the adrenal medulla, which were studied by transmission electron microscopy. Tumour pheochromocytes presented a highly characteristic cytoplasmic admixture of normal resting granules, swollen granules with eroded matrices and enlarged empty containers.
Enrico Crivellato +3 more
openalex +5 more sources
A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae [PDF]
, 2013 The aim of this study was to explore the mechanisms of resistance against invading Ascaris suum larvae in pigs. Pigs received a low dose of 100 A. suum eggs daily for 14 weeks.
Chiers, Koen +6 more
core +9 more sources
Degranulation response in cytotoxic rat lymphocytes measured with a novel CD107a antibody
Frontiers in Immunology, 2016 Measuring degranulation through CD107a expression has become an advantageous tool for testing the functional capacity of cytotoxic cells. Such functional studies have been hampered in the rat by the lack of a suitable anti-rat CD107a antibody.
Amanda Sudworth +3 more
doaj +1 more source
Tissue eosinophilia and eosinophil degranulation in Riedel's invasive fibrous thyroiditis. [PDF]
, 1996 The etiology of Riedel's invasive fibrous thyroiditis (IFT) has remained obscure. This rare disorder has been confused in the past with the more common fibrous variant of Hashimoto's disease.
Bahn, R. S. +4 more
core +1 more source
Frontiers in Immunology, 2021 Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive ...
Jia Li +10 more
doaj +1 more source
Stimulation of TRPV1 by green laser light [PDF]
, 2012 Low-level laser irradiation of visible light had been introduced as a medical treatment already more than 40 years ago, but its medical application still remains controversial.
Gu, Quanbao +3 more
core +2 more sources
Pharmacology Research & Perspectives, 2020 Acute respiratory virus infections, such as influenza and RSV, are predominant causes of asthma exacerbations. Eosinophils act as a double‐edged sword in exacerbations in that they are activated by viral infections but also can capture and inactivate ...
Yanaika Shari Sabogal Piñeros +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mast cells are well known for their role in allergies and many chronic inflammatory diseases. They release upon stimulation, e.g., via the IgE receptor, numerous bioactive compounds from cytoplasmic secretory granules. The regulation of granule secretion
Gaël Ménasché +5 more
doaj +1 more source