Results 31 to 40 of about 63,047 (307)

ELK4 exerts opposite roles in cytokine/chemokine production and degranulation in activated mast cells

Frontiers in Immunology, 2023
The proliferative potential of mast cells after activation for 3-4h was found to be decreased, which suggests that mast cell degranulation and cell proliferation are differentially regulated.
Yuji Huang, Zhehui Zhu, Weize Li, Yiqin Ge, Yanning Li, Juan Wang, Xia Peng, Lihui Lin, Jia Li, Chen-Ying Liu, Li Li   +10 more
doaj   +1 more source

Human Lactobacillus Strains from the Intestine can Suppress IgE-Mediated Degranulation of Rat Basophilic Leukaemia (RBL-2H3) Cells

Microorganisms, 2016
Mast cells play a critical role in immunoglobulin E (IgE)-mediated allergic diseases, and the degranulation of mast cells is important in the pathogenesis of these diseases. A disturbance of the intestinal microflora, especially of endogenous lactic acid
Gaku Harata, Fang He, Kyoko Takahashi, Akira Hosono, Kenji Miyazawa, Kazutoyo Yoda, Masaru Hiramatsu, Shuichi Kaminogawa   +7 more
doaj   +1 more source

Mechanisms of eosinophil cytokine release

Memorias do Instituto Oswaldo Cruz, 2005
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities
Christianne Bandeira-Melo, Peter F Weller   +1 more
doaj   +1 more source

ANTIMICROBIC MECHANISMS OF NEUTROPHILES AS PERSPECTIVE TARGETS FOR PHARMACOLOGICAL MODULATION OF NON-SPECIFIC PROTECTION OF THE ORGANISM

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Key roles in nonspecific protection of the macroorganism are played by neutrophils — the most numerous pool of leukocytes. During the development of infection these cells phagocytose of microorganisms and also secrete proteolytic enzymes that destroy ...
E. V. Matosova, B. G. Andryukov
doaj   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Transcription Factors in the Development and Pro-Allergic Function of Mast Cells

Frontiers in Allergy, 2021
Mast cells (MCs) are innate immune cells of hematopoietic origin localized in the mucosal tissues of the body and are broadly implicated in the pathogenesis of allergic inflammation.
Mansi Srivastava, Mark H. Kaplan
doaj   +1 more source

Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion

Advanced Healthcare Materials, EarlyView.
Platelet quality deteriorates during storage due to protein and platelet adhesion to current bag materials. Here, polymer coatings are identified that reduce adhesion and translated them to mini‐storage bags. Platelet quality are not impacted, despite significantly reducing adhesion.
Nicolas Pereyra, Kai Yu, Jason Rogalski, Taylor Olivia Da Silva, Parisa Golesorkhi, Madeleine Goldstein, Dana V. Devine, Jayachandran N. Kizhakkedathu   +7 more
wiley   +1 more source

Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils—The Current Knowledge, Pharmacological Modulation and Future Prospects

Frontiers in Pharmacology, 2021
Neutrophils are crucial elements of innate immune system, which assure host defense via a range of effector functions, such as phagocytosis, degranulation, and NET formation.
Barbara Gierlikowska, Albert Stachura, Albert Stachura, Wojciech Gierlikowski, Urszula Demkow   +4 more
doaj   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Human mast cells exhibit an individualized pattern of antimicrobial responses

Immunity, Inflammation and Disease, 2020
Introduction Mast cells (MCs) are tissue‐resident immune cells implicated in antibacterial responses. These include chemokine secretion, degranulation, and the release of mast cell‐extracellular traps, which are primarily dependent on reactive oxygen ...
Karen M. Garcia‐Rodriguez, Rajia Bahri, Clara Sattentau, Ian S. Roberts, Anu Goenka, Silvia Bulfone‐Paus   +5 more
doaj   +1 more source