Results 41 to 50 of about 63,047 (307)
Advanced Science, EarlyView.This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao +7 more
wiley +1 more source
Advanced Science, EarlyView.The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang +5 more
wiley +1 more source
Frontiers in Immunology, 2023 Neutrophils are a specialized subset of white blood cells, which have the ability to store pre-formed mediators in their cytoplasmic granules. Neutrophils are well-known effector cells involved in host protection against pathogens through diverse ...
Lea Gigon +8 more
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Advanced Science, EarlyView.3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang +17 more
wiley +1 more source
Mast Cells as a Target—A Comprehensive Review of Recent Therapeutic Approaches
Cells, 2023 Mast cells (MCs) are the immune cells distributed throughout nearly all tissues, mainly in the skin, near blood vessels and lymph vessels, nerves, lungs, and the intestines.
Joanna Baran +7 more
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The Journal of Cell Biology, 2005 ![][1] Degranulation relies on transport by an induced microtubule network (green, right). Degranulation of mast cells involves a two-step process, report Nishida et al. on [page 115][2].
openaire +3 more sources
Evidence for eosinophil degranulation in acute appendicitis
Indian Journal of Pathology and Microbiology, 2008 Finding of increased numbers of eosinophils in the muscle in cases of acute appendicitis has led to the hypothesis that it may have an allergic origin. This study aimed to measure the eosinophil degranulation resulting in a rise in the serum of eosinophil granule proteins that would be expected in such cases.
K P Aravindan, G Santosh
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Advanced Science, EarlyView.Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara +3 more
wiley +1 more source
Role of female sex hormones, estradiol and progesterone, in mast cell behaviour
Frontiers in Immunology, 2012 Female sex hormones have long been suspected to have an effect on mast cell (MC) behaviour. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different
Oliver eZierau +2 more
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Degranulation of Mast Cells as a Target for Drug Development
Cells, 2023 Mast cells act as key effector cells of inflammatory responses through degranulation. Mast cell degranulation is induced by the activation of cell surface receptors, such as FcεRI, MRGPRX2/B2, and P2RX7.
Bo-Gie Yang +5 more
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