Results 51 to 60 of about 137,298 (386)

In-depth characterization of NK cell markers from CML patients who discontinued tyrosine kinase inhibitor therapy

Frontiers in Immunology, 2023
IntroductionTreatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase is considered a safe option if suitable molecular monitoring is available.
María Belén Sanchez, Bianca Vasconcelos Cordoba, Carolina Pavlovsky, Beatriz Moiraghi, Ana Varela, Rosario Custidiano, Isolda Fernandez, María Josefina Freitas, María Verónica Ventriglia, Georgina Bendek, Romina Mariano, María José Mela Osorio, Miguel Arturo Pavlovsky, Ana García de Labanca, Cecilia Foncuberta, Isabel Giere, Masiel Vera, Mariana Juni, José Mordoh, Julio Cesar Sanchez Avalos, Estrella Mariel Levy, Michele Bianchini   +21 more
doaj   +1 more source

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]

, 2018
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura, Giusti, Pietro, Skaper, Stephen D., Zusso, Morena   +3 more
core   +2 more sources

Video-Rate Bioluminescence Imaging of Degranulation of Mast Cells Attached to the Extracellular Matrix

Frontiers in Cell and Developmental Biology, 2018
Degranulation refers to the secretion of inflammatory mediators, such as histamine, serotonin, and proteases, that are stored within the granules of mast cells and that trigger allergic reactions.
Satoru Yokawa, Takahiro Suzuki, Ayumi Hayashi, Satoshi Inouye, Yoshikazu Inoh, Tadahide Furuno   +5 more
doaj   +1 more source

Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation

Frontiers in Immunology, 2023
Neutrophils are a specialized subset of white blood cells, which have the ability to store pre-formed mediators in their cytoplasmic granules. Neutrophils are well-known effector cells involved in host protection against pathogens through diverse ...
Lea Gigon, Timothée Fettrelet, Marta Miholic, Marta Miholic, Kenneth R. McLeish, Shida Yousefi, Darko Stojkov, Hans-Uwe Simon, Hans-Uwe Simon   +8 more
doaj   +1 more source

Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]

, 1990
Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H., Jochum, Marianne, Schiffl, H., Spannagl, Michael   +3 more
core   +1 more source

Nasal epithelial barrier dysfunction increases sensitization and mast cell degranulation in the absence of allergic inflammation

Allergy. European Journal of Allergy and Clinical Immunology, 2019
Increased epithelial permeability has been reported in allergic rhinitis, with histamine and type‐2 inflammation being responsible for tight junction dysfunction.
I. Kortekaas Krohn, S. Seys, G. Lund, Anne-Charlotte Jonckheere, Isabelle Dierckx de Casterlé, J. Ceuppens, B. Steelant, P. Hellings   +7 more
semanticscholar   +1 more source

SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts

Biomedicines, 2022
SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as an important correlate to poor recovery rates in severe COVID-19 ...
Abenaya Muralidharan, Todd A. Wyatt, St Patrick Reid   +2 more
doaj   +1 more source

The minor house dust mite allergen Der p 13 is a fatty acid binding protein and an activator of a TLR2-mediated innate immune response [PDF]

, 2016
Background: The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response.
Banerjee, Batard, Bergenhenegouwen, Bublin, Calderón, Chan, Chiou, Eriksson, Eriksson, Gillilan, Gras, Guillot, Herre, Hunter, Jacquet, Jacquet, Jacquet, Jenkins, Jeong, Jimenez, Kennedy, Kennedy, Kidon, Kitajima, Lambrecht, Li, Liang, Liu, Mei, Mueller, Mueller, Osterlund, Puerta, Pulsawat, Ryu, Soh, Storch, Taylor, Thomas, Tovey, Trompette, Tully, Wiegand, Young, Zähringer   +44 more
core   +1 more source

Transcription Factors in the Development and Pro-Allergic Function of Mast Cells

Frontiers in Allergy, 2021
Mast cells (MCs) are innate immune cells of hematopoietic origin localized in the mucosal tissues of the body and are broadly implicated in the pathogenesis of allergic inflammation.
Mansi Srivastava, Mark H. Kaplan
doaj   +1 more source

IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming

Cells, 2019
Clinically relevant exocytosis of mast cell (MC) mediators can be triggered by high-affinity IgE receptor (FcεRI)-aggregation (allergic route) or by the so-called pseudo-allergic pathway elicited via MAS-related G protein-coupled receptor-X2 (MRGPRX2 ...
Zhao Wang, S. Guhl, K. Franke, M. Artuc, T. Zuberbier, M. Babina   +5 more
semanticscholar   +1 more source