Results 51 to 60 of about 1,228 (155)
Journal of Global Antimicrobial Resistance, 2020 Objectives: Delafloxacin is a broad-spectrum anionic fluoroquinolone with activity against Gram-positive and Gram-negative organisms, including methicillin-resistant Staphylococcus aureus.
Dee Shortridge +3 more
doaj +1 more source
Delafloxacin: First Global Approval [PDF]
Drugs, 2017 Delafloxacin (Baxdela™) is a fluoroquinolone antibacterial with activity against both gram-positive and gram-negative pathogens being developed by Melinta Therapeutics. The drug is being investigated or considered as a treatment for various bacterial infections and in June 2017 received approval in the USA for the treatment of acute bacterial skin and ...
openaire +2 more sources
Correction to: Delafloxacin: First Global Approval [PDF]
Drugs, 2018 The article Delafloxacin: First Global Approval, written by Anthony Markham, was originally published Online First without open access.
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A novel liquid chromatography‐fluorescence method for the determination of delafloxacin in human plasma [PDF]
, 2022 © 2021 Wiley-VCH GmbH. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published Manuscript, version of a Published Work that appeared in final form in ...
Verónica Hernandis +5 more
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Delafloxacin Pharmacokinetics in Subjects With Varying Degrees of Renal Function [PDF]
The Journal of Clinical Pharmacology, 2017 AbstractDelafloxacin, a fluoroquinolone, has activity against gram‐positive organisms including methicillin‐resistant Staphylococcus aureus and fluoroquinolone‐susceptible and –resistant gram‐negative organisms. This study was conducted to determine delafloxacin pharmacokinetics after a single intravenous infusion or oral dose administration in ...
Randall K. Hoover +5 more
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Single and Multiple Ascending-dose Studies of Oral Delafloxacin: Effects of Food, Sex, and Age [PDF]
, 2016 PurposeThe objective of this report is describe the results of 2 studies that examined the pharmacokinetic parameters, safety profile, and tolerability of single and multiple ascending doses of oral delafloxacin and the effects of food, sex, and age on ...
Hoover, Randall +6 more
core +1 more source
Efficacy of Delafloxacin against the Biothreat Pathogen Burkholderia pseudomallei
Antimicrobial Agents and Chemotherapy, 2021 The in vitro activity and in vivo efficacy of delafloxacin were evaluated against the causative pathogen of melioidosis, Burkholderia pseudomallei . Delafloxacin MICs were determined by broth microdilution according to CLSI guidelines for 30 isolates of B ...
Sandra McCurdy +4 more
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Separations, 2021 A novel UPLC-MS/MS assay was developed for rapid quantification of delafloxacin (a novel fluoroquinolone antibiotic in plasma samples by one step sample cleanup procedure.
Muzaffar Iqbal +3 more
doaj +1 more source
, 2020 20.500.12530/87858We report the activity of delafloxacin, a new fluoroquinolone with high affinity for both topoisomerase IV and DNA gyrase, against highly-levofloxacin-resistant invasive strains of Streptococcus pneumoniae.
Cercenado, Emilia +3 more
core +1 more source
Safety, Tolerability, and Pharmacokinetic Properties of Intravenous Delafloxacin After Single and Multiple Doses in Healthy Volunteers [PDF]
, 2016 PurposeThe objective of this report was to determine the pharmacokinetic properties, safety, and tolerability of single and multiple doses of intravenous delafloxacin.
Hoover, Randall +6 more
core +1 more source