Results 31 to 40 of about 2,707 (157)

Effectiveness and cardiovascular safety of delamanid-containing regimens in adults with multidrug-resistant or extensively drug-resistant tuberculosis: A nationwide cohort study from Belarus, 2016-18

Monaldi Archives for Chest Disease, 2021
To address the sub-optimal treatment outcomes among patients with multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), the National TB Programme in Belarus started using new drugs such as bedaquiline and delamanid in 2015-16.
Vera Auchynka, Ajay M.V. Kumar, Hennadz Hurevich, Yuliia Sereda, Varvara Solodovnikova, Dzmitry Katovich, Svetlana Setkina, Askar Yedilbayev, Aliaksandr Skrahin, Alena Skrahina   +9 more
doaj   +1 more source

Delamanid in the Treatment of MDR/pre-XDR TB in Arkhangelsk Region in 2019–2021

Туберкулез и болезни лёгких, 2023
The objective: to evaluate the efficacy and safety of delamanid in a short-course treatment regimen for patients with MDR/pre-XDR pulmonary tuberculosis in Arkhangelsk Region from 2019 to 2021.Subjects and Methods.
E. S. Khimova, D. V. Perkhin, O. M. Sveshnikova, S. V. Makhmaeva, V. N. Verkhovaya, P. I. Eliseev, E. I. Nikishova, A. O. Maryandyshev   +7 more
doaj   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Clinical outcomes of multidrug-resistant tracheobronchial tuberculosis receiving anti-tuberculosis regimens containing bedaquiline or delamanid

Scientific Reports
The treatment of multidrug-resistant tracheobronchial tuberculosis poses challenges, and research investigating the efficacy of bedaquiline or delamanid as treatment for this condition is limited.
Qing Chen, Tao Huang, Liping Zou, Xianzhen Tang, Zhengyu Shi, Xinwei Wang, Huaige Wu, Jiying Sun, Xiaoli Lu, Li Liang, Liangshuang Jiang, Dafeng Liu, Shenjie Tang, Guihui Wu, Wei He   +14 more
doaj   +1 more source

Solid Lipid Nanoparticles Enhancing the Leishmanicidal Activity of Delamanid

Pharmaceutics, 2023
Leishmaniasis, a zoonotic parasitic disease transmitted by infected sandflies, impacts nearly 1 million people yearly and is endemic in many countries across Asia, Africa, the Americas, and the Mediterranean; despite this, it remains a neglected disease with limited effective treatments, particularly in impoverished communities with limited access to ...
Javier Santamaría-Aguirre, Daniela Jacho, Miguel A. Méndez, Ana Poveda, Javier Carrión, Mónica L. Fanarraga   +5 more
openaire   +5 more sources

A 9‐Year‐Old Boy With Right‐Sided Extrapulmonary Drug‐Resistant Tuberculosis Subphrenic Abscess: A Case Report From Woldia, Northeast Ethiopia

Clinical Case Reports, Volume 14, Issue 3, March 2026.
Coronal reconstruction post contrast thoraco‐abdominal CT of a 9 years old boy taken December, 2023. This shows 1.45 by 3.9 cms hypodense collection having rim enhancement in the right anterio‐inferior sub‐phrenic space suggestive of abscess. ABSTRACT Diagnosing extrapulmonary and drug‐resistant tuberculosis in children is challenging.
Animaw Lingerew, Samuel Addis, Adugnaw Atnafu, Zeru Siyoum, Solomie Jebessa Deribessa   +4 more
wiley   +1 more source

Rezultatele tratamentului tuberculozei multidrogrezistente cu utilizarea bedaquiline şi delamanid

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2021
Rezultatele tratamentului tuberculozei multidrogrezistente cu utilizarea bedaquiline şi delamanid Articolul prezintă rezultatele unei analize a eficacităţii şi siguranţei bedaquilinei şi delamanidului la pacienţii cu tuberculoză multidrogrezistentă (TB ...
Rafig Bayramov, Jeyhun Ismayilzada, Orkhan Suleymanov   +2 more
doaj   +1 more source

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

Protein Target Highlights in CASP16: Insights From the Structure Providers

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.
ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander, Océane M. Follonier, Andriy Kryshtafovych, Kim Abesamis, Sabrina Bibi‐Triki, Henry G. Box, Cécile Breyton, Françoise Bringel, Loic Carrique, Alessio d'Acapito, Gang Dong, Rebecca DuBois, Deborah Fass, Juliana Martinez Fiesco, Daniel R. Fox, Jonathan M. Grimes, Rhys Grinter, Matthew Jenkins, Roman Kamyshinsky, Jeremy R. Keown, Gerald Lackner, Michael Lammers, Shiheng Liu, Andrew L. Lovering, Tomas Malinauskas, Benoît Masquida, Gottfried J. Palm, Christian Siebold, Tiantian Su, Ping Zhang, Z. Hong Zhou, Krzysztof Fidelis, Maya Topf, John Moult, Torsten Schwede   +34 more
wiley   +1 more source

Drug resistance to delamanid was detected in susceptible tuberculosis patient in Russia

Journal of Global Antimicrobial Resistance
AIM: To detect mutations in M. tuberculosis (MTB) associated with delamanid drug resistance in patients with tuberculosis (TB) in Russia. BACKGROUND: Delamanid is important in treatment of multi- and extensively drug-resistant TB.
Platon Eliseev, Irina Vasilyeva, Anatoly Vinokurov, Evgeny Kuznetsov, Kirill Baibekov, Anastasia Kazulina, Anastasia Samoilova   +6 more
doaj   +1 more source