Results 41 to 50 of about 2,707 (157)

Experience of Using Delamanid in the Treatment of Multiple Drug Resistant Tuberculosis

Туберкулез и болезни лёгких
The objective: to evaluate treatment results in MDR TB patients when delamanid is added to the treatment regimen.Subjects and Methods. 91 patients with multiple drug resistant pulmonary tuberculosis were included in the study, of which 36 people (39.6 ...
T. R. Bagdasaryan, M. A. Plekhanova, V. Yu. Smirnov, E. A. Grigorieva, Yu. I. Timakova, A. S. Goncharov   +5 more
doaj   +1 more source

Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases

Molecules, 2020
Nitroimidazole drugs have a long history as therapeutic agents to treat bacterial and parasitic diseases. The discovery in 1989 of a bicyclic nitroimidazole lead, displaying in vitro and in vivo antitubercular activity, spurred intensive exploration of ...
Hollis D. Showalter
doaj   +1 more source

Advances of new drugs bedaquiline and delamanid in the treatment of multi-drug resistant tuberculosis in children

Frontiers in Cellular and Infection Microbiology, 2023
Tuberculosis (TB) is a major public health problem, with nearly 10 million new cases and millions of deaths each year. Around 10% of these cases are in children, but only a fraction receive proper diagnosis and treatment. The spread of drug-resistant (DR)
Hanzhao Zhu, Hanzhao Zhu, Xintong Zhou, Zengfang Zhuang, Zengfang Zhuang, Lianju Li, Lianju Li, Jing Bi, Kaixia Mi, Kaixia Mi   +9 more
doaj   +1 more source

All‐Oral Shorter Treatment Regimens for Multidrug‐ and Rifampicin‐Resistant Tuberculosis: Evaluating Their Effectiveness, Safety, and Impact on the Quality of Life of Patients in Lao PDR

Tropical Medicine &International Health, Volume 30, Issue 12, Page 1340-1353, December 2025.
ABSTRACT Background Drug‐resistant tuberculosis remains a major public health challenge in Lao PDR, with low second‐line treatment uptake and suboptimal outcomes. To improve effectiveness, safety, and tolerability, a shorter all‐oral regimen for multidrug‐ and rifampicin‐resistant tuberculosis (MDR/RR‐TB) was introduced under the TDR Short, all‐Oral ...
Vibol Iem, Sakhone Suthepmany, Vongkham Inthavong, Anousone Sisouvanh, Khamloun Choumlivong, Kyung Hyun Oh, Philipp du Cros, Fatimata Bintou Sall, Corinne S. Merle, Jacques Sebert, Donekham Inthavong   +10 more
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

High clustering rate and genotypic drug-susceptibility screening for the newly recommended anti-tuberculosis drugs among global extensively drug-resistant Mycobacterium tuberculosis isolates

Emerging Microbes and Infections, 2022
Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) make TB difficult to control. Global susceptibility data for six newly recommended anti-TB drugs against M/XDR-TB are still limited.
Kanwara Trisakul, Ditthawat Nonghanphithak, Pratchakan Chaiyachat, Orawee Kaewprasert, Kankanon Sakmongkoljit, Wipa Reechaipichitkul, Angkana Chaiprasert, David Blair, Taane G. Clark, Kiatichai Faksri   +9 more
doaj   +1 more source

Black Hairy Tongue as a Rare Adverse Effect of Linezolid in Multidrug‐Resistant Tuberculosis: A Case Report

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Black hairy tongue (BHT), or lingua villosa nigra, is a rare adverse effect of linezolid, an antibiotic frequently used in the treatment of multidrug‐resistant tuberculosis (MDR‐TB). We present a case of a 24‐year‐old female who developed BHT while receiving linezolid as part of a longer regimen for MDR‐TB.
Dipendra Adhikari, Salina Paudel, Munna William, Manoj Kumar Bhatt, Sanju Dahal, Abishkar Gautam, Binay Adhikari   +6 more
wiley   +1 more source

Perspectives of targeted chemotherapy with delamanid in the treatment regimens of those with multiple/extensive drug resistant tuberculosis. A success, chance or uncertainty?

Туберкулез и болезни лёгких, 2018
The article presents the review of current publications, clinical recommendations and guidelines written by foreign authors and devoted to treatment of drug resistant tuberculosis with delamanid.
Aleksey G. Naumov, Aleksandr V. Pavlunin
doaj   +1 more source

Synthesis, Antimycobacterial Activity, and Computational Insight of Novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates against Multidrug‐Resistant Mycobacterium Tuberculosis

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
A series of 14 novel 1,4‐benzoxazinone derivatives is tested against various strains of Mycobacterium tuberculosis. All compounds show high activity against all tested strains, particularly the resistant strains. Additionally, the novel derivatives exhibit low cytotoxicity toward mammalian Vero cells.
Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukič, Daniele Zampieri   +6 more
wiley   +1 more source

Adduct Formation of Delamanid with NAD in Mycobacteria

Antimicrobial Agents and Chemotherapy, 2020
Delamanid (DLM), a nitro-dihydroimidazooxazole derivative currently approved for pulmonary multidrug-resistant tuberculosis (TB) therapy, is a prodrug activated by mycobacterial 7,8-didemethyl-8-hydroxy 5-deazaflavin electron transfer coenzyme (F 420 )-dependent nitroreductase (Ddn).
Mikayo Hayashi, Akihito Nishiyama, Ryuki Kitamoto, Yoshitaka Tateishi, Mayuko Osada-Oka, Yukiko Nishiuchi, Shaban A. Kaboso, Xiuhao Chen, Mamoru Fujiwara, Yusuke Inoue, Yoshikazu Kawano, Masanori Kawasaki, Tohru Abe, Tsutomu Sato, Kentaro Kaneko, Kimiko Itoh, Sohkichi Matsumoto, Makoto Matsumoto   +17 more
openaire   +3 more sources