Results 1 to 10 of about 82,144 (300)

Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure [PDF]

Epigenetics
Histone H4K20 methylation is critical in regulating the cell cycle, DNA damage response, and gene repression in proliferating cells. However, its role in the heart remains poorly understood.
Samuel Hickenlooper, Cameron Brady, Ryan Bia, Joseph R. Visker, Li Wang, Steven Valdez, Clint Gwynn, Maya N. Roland, Christos P. Kyriakopoulos, Konstantinos Sideris, Stavros G. Drakos, Marta W. Szulik, Sarah Franklin   +12 more
doaj   +2 more sources

The Lysine Demethylase dKDM2 Is Non-essential for Viability, but Regulates Circadian Rhythms in Drosophila

Frontiers in Genetics, 2018
Post-translational modification of histones, such as histone methylation controlled by specific methyltransferases and demethylases, play critical roles in modulating chromatin dynamics and transcription in eukaryotes.
Yani Zheng, Yongbo Xue, Xingjie Ren, Mengmeng Liu, Xiao Li, Yu Jia, Ye Niu, Jian-Quan Ni, Yong Zhang, Jun-Yuan Ji   +9 more
doaj   +2 more sources

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

Nature Communications, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Seungwon Yang, Jiangbo Wei, Yan-Hong Cui
exaly   +2 more sources

Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5 [PDF]

Epigenetics & Chromatin
Background Lysine demethylase 5 (KDM5) family proteins are transcriptional regulators best known for demethylating the promoter-proximal histone mark H3K4me3.
Matanel Yheskel, Melissa A. Castiglione, Julie Secombe   +2 more
doaj   +2 more sources

Effects of Cyclamen trochopteranthum on hepatic drug-metabolizing enzymes [PDF]

Archives of Biological Sciences, 2011
The modulatory effects of the Cyclamen trochopterantum tuber extract on hepatic drug-metabolizing enzymes, including aniline 4-hydroxylase (A4H; CYP2E1), ethoxyresorufin O-deethylase (EROD; CYP1A), methoxyresorufin O-demethylase (MROD; CYP1A ...
Arslan Sevki, Ozgun Ozden, Celik Gurbet, Semiz Asli, Dusen Olcay, Mammadov Ramazan, Sen Alaattin   +6 more
doaj   +4 more sources

Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1 [PDF]

, 2007
In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two
Abdelhalim Boukaba, Antony M. Carr, BG Mellone, C Martin, Carolina Bonilla, D Robyr, David Lando, E Metzger, E Nicolas, Ernest D. Laue, G Rigaut, GW Humphrey, I Sinha, IM Hall, J Bahler, J Nakayama, James Cauwood, JF Flanagan, JJ Tasto, Juan Valcarcel, Julian Walfridsson, K Noma, K Yamane, Karl Ekwall, M Wiren, MA Hakimi, MG Lee, MG Lee, Michael Opel, MJ Buck, Natalia V. Murzina, P Bjerling, PA Cloos, Petra J.H. Werler, PJ Werler, R Schneider, RJ Klose, RJ Sims 3rd, Robin C. Allshire, Sarah C. Trewick, SI Grewal, SK Kurdistani, Tony Kouzarides, U Kleeberg, Y Shi, Y Shi, Y Tsukada, Y Xue, YJ Shi   +48 more
core   +14 more sources

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2022
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang, Runjiao Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Fangzhen Guo, Fangzhen Guo, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +12 more
doaj   +1 more source

Gene Expression Profiles of Methyltransferases and Demethylases Associated with Metastasis, Tumor Invasion, CpG73 Methylation, and HPV Status in Head and Neck Squamous Cell Carcinoma

Current Issues in Molecular Biology, 2023
Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan, Tomaž Büdefeld, Helena Čelešnik, Matija Švagan, Boštjan Lanišnik, Uroš Potočnik   +5 more
doaj   +1 more source

Dynamics of H3K27me3 Modification on Plant Adaptation to Environmental Cues

Plants, 2021
Given their sessile nature, plants have evolved sophisticated regulatory networks to confer developmental plasticity for adaptation to fluctuating environments.
Qingwen Shen, Yisheng Lin, Yingbo Li, Guifeng Wang   +3 more
doaj   +1 more source

Effects of aluminum on expressions of fat mass and obesity-associated protein and brain-derived neurotrophic factor in rat brain and PC12 cells

环境与职业医学, 2022
BackgroundChemical modification of RNA is a recent hotspot in the field of epigenetics, but the specific mechanism of chemical modification of RNA in aluminum neurotoxicity has not been fully reported.ObjectiveTo investigate the alterations of fat mass ...
Mengtong XU, Tiantian WANG, Wenjing LI, Chunman YUAN, Jing SONG   +4 more
doaj   +1 more source