Results 1 to 10 of about 36,880 (185)

DNA Demethylase Is a Processive Enzyme [PDF]

Journal of Biological Chemistry, 1999
DNA methylation patterns are generated during development by a sequence of methylation and demethylation events. We have recently demonstrated that mammals bear a bona fide demethylase enzyme that removes methyl groups from methylated cytosines. A general genome wide demethylation occurs early in development and in differentiating cell lines.
Sanjoy K. Bhattacharya, Moshe Szyf, Nadia Cervoni   +2 more
openaire   +4 more sources

H3K27 Demethylases, at Long Last [PDF]

Cell, 2007
Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove ...
Joanna Wysocka, Tomek Swigut
openaire   +5 more sources

Structural requirements for substrate recognition of Mycobacterium tuberculosis 14α-demethylase: implications for sterol biosynthesis [PDF]

Journal of Lipid Research, 2001
Sterol 14α-demethylase (14DM) is a cytochrome P-450 involved in sterol biosynthesis in eukaryotes. It was reported that Mycobacterium smegmatis also makes cholesterol and that cholesterol is essential to Mycobacterium tuberculosis (MT) infection ...
Aouatef Bellamine, Anil T. Mangla, Allen L. Dennis, W. David Nes, Michael R. Waterman   +4 more
doaj   +2 more sources

Current Perspectives on Histone Demethylases [PDF]

Acta Biochimica et Biophysica Sinica, 2007
The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones.
Xiaoqing Tian, Jingyuan Fang
openaire   +3 more sources

Effects of Cyclamen trochopteranthum on hepatic drug-metabolizing enzymes [PDF]

Archives of Biological Sciences, 2011
The modulatory effects of the Cyclamen trochopterantum tuber extract on hepatic drug-metabolizing enzymes, including aniline 4-hydroxylase (A4H; CYP2E1), ethoxyresorufin O-deethylase (EROD; CYP1A), methoxyresorufin O-demethylase (MROD; CYP1A ...
Arslan Sevki, Celik Gurbet, Dusen Olcay, Mammadov Ramazan, Ozgun Ozden, Semiz Asli, Sen Alaattin   +6 more
core   +3 more sources

The Functions of the Demethylase JMJD3 in Cancer [PDF]

International Journal of Molecular Sciences, 2021
Cancer is a major cause of death worldwide. Epigenetic changes in response to external (diet, sports activities, etc.) and internal events are increasingly implicated in tumor initiation and progression. In this review, we focused on post-translational changes in histones and, more particularly, the tri methylation of lysine from histone 3 (H3K27me3 ...
Sanchez, Anna, Houfaf Khoufaf, Fatma Zohra, Idrissou, Mouhamed, Penault-Llorca, Frédérique, Bignon, Yves-Jean, Guy, Laurent, Bernard-Gallon, Dominique   +6 more
openaire   +4 more sources

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2022
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang, Runjiao Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Fangzhen Guo, Fangzhen Guo, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +12 more
doaj   +1 more source

Gene Expression Profiles of Methyltransferases and Demethylases Associated with Metastasis, Tumor Invasion, CpG73 Methylation, and HPV Status in Head and Neck Squamous Cell Carcinoma

Current Issues in Molecular Biology, 2023
Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan, Tomaž Büdefeld, Helena Čelešnik, Matija Švagan, Boštjan Lanišnik, Uroš Potočnik   +5 more
doaj   +1 more source

Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1 [PDF]

, 2007
In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two
Abdelhalim Boukaba, Antony M. Carr, BG Mellone, C Martin, Carolina Bonilla, D Robyr, David Lando, E Metzger, E Nicolas, Ernest D. Laue, G Rigaut, GW Humphrey, I Sinha, IM Hall, J Bahler, J Nakayama, James Cauwood, JF Flanagan, JJ Tasto, Juan Valcarcel, Julian Walfridsson, K Noma, K Yamane, Karl Ekwall, M Wiren, MA Hakimi, MG Lee, MG Lee, Michael Opel, MJ Buck, Natalia V. Murzina, P Bjerling, PA Cloos, Petra J.H. Werler, PJ Werler, R Schneider, RJ Klose, RJ Sims 3rd, Robin C. Allshire, Sarah C. Trewick, SI Grewal, SK Kurdistani, Tony Kouzarides, U Kleeberg, Y Shi, Y Shi, Y Tsukada, Y Xue, YJ Shi   +48 more
core   +11 more sources

Dynamics of H3K27me3 Modification on Plant Adaptation to Environmental Cues

Plants, 2021
Given their sessile nature, plants have evolved sophisticated regulatory networks to confer developmental plasticity for adaptation to fluctuating environments.
Qingwen Shen, Yisheng Lin, Yingbo Li, Guifeng Wang   +3 more
doaj   +1 more source