Results 1 to 10 of about 43,841 (247)

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2022
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang, Runjiao Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Fangzhen Guo, Fangzhen Guo, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +12 more
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Gene Expression Profiles of Methyltransferases and Demethylases Associated with Metastasis, Tumor Invasion, CpG73 Methylation, and HPV Status in Head and Neck Squamous Cell Carcinoma

Current Issues in Molecular Biology, 2023
Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan, Tomaž Büdefeld, Helena Čelešnik, Matija Švagan, Boštjan Lanišnik, Uroš Potočnik   +5 more
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Dynamics of H3K27me3 Modification on Plant Adaptation to Environmental Cues

Plants, 2021
Given their sessile nature, plants have evolved sophisticated regulatory networks to confer developmental plasticity for adaptation to fluctuating environments.
Qingwen Shen, Yisheng Lin, Yingbo Li, Guifeng Wang   +3 more
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The Latest Research Progress of m6A Modification and Its Writers, Erasers, Readers in Infertility: A Review

Frontiers in Cell and Developmental Biology, 2021
Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N6-methyladenosine (m6A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by ...
Xuda Liu, Haiying Wang, Bingchen Liu, Zhipeng Qi, Jiashuo Li, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng   +8 more
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Effects of aluminum on expressions of fat mass and obesity-associated protein and brain-derived neurotrophic factor in rat brain and PC12 cells

环境与职业医学, 2022
BackgroundChemical modification of RNA is a recent hotspot in the field of epigenetics, but the specific mechanism of chemical modification of RNA in aluminum neurotoxicity has not been fully reported.ObjectiveTo investigate the alterations of fat mass ...
Mengtong XU, Tiantian WANG, Wenjing LI, Chunman YUAN, Jing SONG   +4 more
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Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus

Frontiers in Plant Science, 2022
The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao, Qi Guo, Sen Cao, Yanting Tian, Kunjin Han, Yuhan Sun, Juan Li, Qingshan Yang, Qingju Ji, Ronald Sederoff, Yun Li   +10 more
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Expressions of m6A methyltransferases and their associations with microR-21 and transforming growth factor-β1 in kidney of rats exposed to cadmium

环境与职业医学, 2022
BackgroundEnvironmental pollutants can affect N6-methyladenosine (m6A) level in the body, but the change of m6A level in kidney after being exposed to cadmium (Cd) and the molecular mechanism of renal injury need to be further studied.
Qian YANG, Yifan ZHANG, Zhichao HAN, Rujie LIU, Yuxing LI, Weitong SHEN, Yufen LIANG, Jiachen ZHANG, Shuangjing LI, Han ZHOU, Lijian LEI   +10 more
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Fear Stress During Pregnancy Affects Placental m6A-Modifying Enzyme Expression and Epigenetic Modification Levels

Frontiers in Genetics, 2022
As the hub connecting mother and offspring, the placenta’s normal development is vital for fetal growth. Fear stress can cause some structural alterations in the placenta and affect placental development and function. N6-methyladenosine (m6A) is the most
Qiyang Wang, Mingmin Pan, Tong Zhang, Yu Jiang, Peiyuan Zhao, Xihong Liu, Anqi Gao, Liping Yang, Junlin Hou   +8 more
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Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

Frontiers in Neuroscience, 2020
Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han, Zhen Liu, Yingying Xu, Xiangtian Liu, Dewei Wang, Fan Li, Yun Wang, Jianzhong Bi   +7 more
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Biological and therapeutic role of LSD1 in Alzheimer’s diseases

Frontiers in Pharmacology, 2022
Alzheimer’s disease (AD) is a common chronic neurodegenerative disease characterized by cognitive learning and memory impairments, however, current treatments only provide symptomatic relief.
Yu Li, Yuanyuan Zhao, Xiaona Li, Liuqun Zhai, Hua Zheng, Ying Yan, Qiang Fu, Jinlian Ma, Haier Fu, Zhenqiang Zhang, Zhonghua Li   +10 more
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