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m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]
Nature Communications, 2019 Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Seungwon Yang, Jiangbo Wei, Palak Shah
exaly +4 more sources
Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure [PDF]
EpigeneticsHistone H4K20 methylation is critical in regulating the cell cycle, DNA damage response, and gene repression in proliferating cells. However, its role in the heart remains poorly understood.
Samuel Hickenlooper +12 more
doaj +2 more sources
Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5 [PDF]
Epigenetics & ChromatinBackground Lysine demethylase 5 (KDM5) family proteins are transcriptional regulators best known for demethylating the promoter-proximal histone mark H3K4me3.
Matanel Yheskel +2 more
doaj +2 more sources
RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease
Frontiers in Cellular Neuroscience, 2022 The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang +12 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan +5 more
doaj +1 more source
Dynamics of H3K27me3 Modification on Plant Adaptation to Environmental Cues
Plants, 2021 Given their sessile nature, plants have evolved sophisticated regulatory networks to confer developmental plasticity for adaptation to fluctuating environments.
Qingwen Shen +3 more
doaj +1 more source
环境与职业医学, 2022 BackgroundChemical modification of RNA is a recent hotspot in the field of epigenetics, but the specific mechanism of chemical modification of RNA in aluminum neurotoxicity has not been fully reported.ObjectiveTo investigate the alterations of fat mass ...
Mengtong XU +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N6-methyladenosine (m6A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by ...
Xuda Liu +8 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2021 Non-small cell lung cancer (NSCLC) represents one of the primary causes of cancer-related mortality all over the world. Following our initial finding of the upregulated expression of E2F transcription factor-1 (E2F1) in the NSCLC-related microarray, this
Yanyun Wang +4 more
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Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease
Frontiers in Neuroscience, 2020 Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han +7 more
doaj +1 more source