Results 191 to 200 of about 95,899 (339)

Overexpression of RNA m⁶A demethylase FTO enhances the yield of natural rubber in lettuce. [PDF]

Mol Hortic
Hu B, Yang N, Li W, Zheng Z, Lin Y, Wang K, Chen J, Zhou Z, Qin Y, Qiu S, Huang H, Li J, Long X.   +12 more
europepmc   +1 more source

Comprehensive Quantification of Oligoasthenozoospermia Induced by Obesity, Reproductive Toxicants, and Their Combination in Rat Models

Andrology, EarlyView.
ABSTRACT Background Oligoasthenozoospermia is a leading cause of male infertility and has been increasingly associated with the global surge in obesity and exposure to reproductive toxicants. Despite extensive research on each factor individually, their combined pathological effects remain poorly understood.
Yunlong Yao, Xi Zhang, Lingru Li, Yunzhi Zhang, Shuo Huang, Yulin Zong, Mingrui Li, Fufangyu Zhao, Linghui Zhu, Tianxing Li, Wenlong Sun, Mingyan Shao, Yanfei Zheng   +12 more
wiley   +1 more source

ALKBH1L Is an m⁶A Demethylase and Mediates PVY Infection in <i>Nicotiana benthamiana</i> Through m⁶A Modification. [PDF]

Plants (Basel)
Zhou J, Sun S, Yuan J, Dong L, Wang X, Jing C, Nawaz MA, Tang R, Cao H, Nie B, Feng X.   +10 more
europepmc   +1 more source

Selective small molecule targeting of KDM4 as a therapeutic strategy to reduce proliferation of acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is an aggressive disease with poor survival and high relapse rates. Coupled with the complex mutational burden observed, there is an unmet clinical need for more targeted therapies. Epigenetic therapies have shown promise both as monotherapy and in combination strategies and specifically histone lysine demethylase,
Laura Monaghan, Roderick P. Bunschoten, Joana Bittencourt‐Silvestre, Taeju Park, Susan Gannon, Petrisor Alin Pirvan, Alex Hoose, Helen Wheadon, Robert M. J. Liskamp, Xu Huang, Heather G. Jørgensen   +10 more
wiley   +1 more source

Histone lysine demethylases in breast cancer: molecular mechanisms, biological functions, and therapeutic intervention. [PDF]

Mol Cancer
Wang A, Qi D, Ma Y, Wang M, Dong H, Wang C, Zhang Y, Zhang Z, Li L, Xu J, Yao L, Xu Y.   +11 more
europepmc   +1 more source

Demethylases Need PHDs♦ [PDF]

Journal of Biological Chemistry, 2010
openaire   +1 more source

FB23‐2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex

Cancer Science, EarlyView.
FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang, Hongshi Cai, Yue Zhu, Jianfeng Liang, Hongyu Li, Fan Song, Ziyi Wang, Jinsong Hou   +7 more
wiley   +1 more source

Editorial: The emerging role of protein methylation/demethylation modification in disease and homeostasis

Frontiers in Molecular Biosciences
Yan-Jun Liu, Jian-Fei Lu, Xin Peng, Guan-Jun Yang   +3 more
doaj   +1 more source

Purification and characterization of a dihydroxy Oxocyclohexyl acetate derivative from endophytic Aspergillus Candidus targeting Candida albicans lanosterol 14α-Demethylase. [PDF]

Sci Rep
Saleem A, Khattak SU, Ahmad S, Ahmad A, Alsagri HS, Menshawi A.   +5 more
europepmc   +1 more source

Biological roles of LSD1 beyond its demethylase activity

Cellular and Molecular Life Sciences, 2020
Feiying Gu, Yuxin Lin, Zhun Wang, Xiaoxin Wu, Z. Ye, Yuezhen Wang, Huiyin Lan   +6 more
semanticscholar   +1 more source