Results 191 to 200 of about 98,772 (389)

Loss of the Y Chromosome in Oral Potentially Premalignant Disorders Predicts Malignant Progression: An Integrative Cross‐Species Multi‐Cohort Bioinformatic Study

Head &Neck, EarlyView.
ABSTRACT Background The loss of the Y chromosome (LOY) and the extreme down‐regulation of Y chromosome gene expression (EDY) are frequently observed in oral squamous cell carcinoma (OSCC). However, their roles in oral potentially malignant disorders (OPMDs) are unclear.
Rui Han, Jos B. Poell, Cristina Conde‐Lopez, Tuula Salo, Ina Kurth, Ruud H. Brakenhoff, Jochen Hess   +6 more
wiley   +1 more source

m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.

Cancer Cell, 2017
Sicong Zhang, B. Zhao, Aidong Zhou, Kangyu Lin, Shaoping Zheng, Zhike Lu, Yaohui Chen, E. Sulman, K. Xie, O. Bögler, S. Majumder, Chuan He, Suyun Huang   +12 more
semanticscholar   +1 more source

Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations

, 2022
Fatima S. Ugur, Mark J. S. Kelly, Danica Galonić Fujimori   +2 more
openalex   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

Cell Stem Cell, 2020
Chao Shen, Yue Sheng, Allen C. Zhu, S. Robinson, Xi Jiang, Lei Dong, Huiying Chen, R. Su, Zhe Yin, Wei Li, Xiaolan Deng, Yinhuai Chen, Yueh-Chiang Hu, Hengyou Weng, Huilin Huang, Emily A. Prince, C. Cogle, Miao Sun, Bin Zhang, Chun-Wei Chen, G. Marcucci, Chuan He, Zhijian Qian, Jianjun Chen   +23 more
semanticscholar   +1 more source

JmjC‐domain containing histone demethylase 1B‐mediated p15^Ink4b suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia

, 2011
Satoki Nakamura, Lin Tan, Yasuyuki Nagata, Tomonari Takemura, Aya Asahina, Daisuke Yokota, Tomohiro Yagyu, Kiyoshi Shibata, Shinya Fujisawa, Kazunori Ohnishi   +9 more
openalex   +2 more sources

m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite [PDF]

, 2018
Lulu Bai, Qianghu Tang, Zhen Zou, Meng Pan, Baijie Tu, Yinyin Xia, Shuqun Cheng, Lina Zhang, Kai Yang, Shaoyu Mu, Xuefeng Wang, Xia Qin, Bo Lv, Xianqing Cao, Qizhong Qin, Xuejun Jiang, Chengzhi Chen   +16 more
openalex   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Fumonisin B1 induces global DNA hypermethylation in human glioblastoma U87MG cells

Epigenetics
Fumonisin B1 (FB1) is a common maize contaminant known to induce toxicity and carcinogenesis in humans and animals; however, its epigenetic mechanisms remain poorly understood.
Ashmika Foolchand, Terisha Ghazi, Anil A. Chuturgoon   +2 more
doaj   +1 more source