Results 211 to 220 of about 7,855 (246)

Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster

Journal of Applied Toxicology, Volume 45, Issue 5, Page 841-857, May 2025.
ABSTRACT N‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde, another alkylating agent and DBP. Both compounds are generated from
Oscar Eduardo Tabares‐Mosquera, Javier Andrés Juárez‐Díaz, Rafael Camacho‐Carranza, Patricia Ramos‐Morales   +3 more
wiley   +1 more source

Cancer‐Specific RNA Modifications in Tumour‐Derived Extracellular Vesicles Promote Tumour Growth

Journal of Extracellular Vesicles, Volume 14, Issue 5, May 2025.
ABSTRACT RNA modifications are crucial in cellular processes, and their dysregulation is linked to diseases like cancer. Extracellular vesicles (EVs) contain various RNAs and might be susceptible to modifications, but detecting these modifications has been challenging due to the small amount of RNA in EVs.
Yuya Monoe, Kentaro Jingushi, Kohei Taniguchi, Kensuke Hirosuna, Jun Arima, Yosuke Inomata, Yoshiaki Takano, Hiroki Hamamoto, Kazumasa Komura, Tomohito Tanaka, Hiroaki Hase, Sang‐Woong Lee, Kazutake Tsujikawa   +12 more
wiley   +1 more source

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials

Medicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.
ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis, Marta Ribalta‐Vilella, Alba Irisarri, Pinky Gehlot, Bhanwar Singh Choudhary, Abhisek Jana, Vivek Kumar Vyas, Deb Ranjan Banerjee, Mercè Pallàs, Ana Guerrero, Christian Griñán‐Ferré   +10 more
wiley   +1 more source

Evolving Lessons on Metazoan Primordial Germ Cells in Diversity and Development

Molecular Reproduction and Development, Volume 92, Issue 5, May 2025.
ABSTRACT Germ cells are pivotal for the continuation of biological species. The metazoan germline develops from primordial germ cells (PGCs) that undergo multiple rounds of mitotic divisions. The PGCs are specified by either maternal inheritance of asymmetrically polarized cytoplasmic mRNAs/proteins (found in roundworms, flies, fishes, frogs, and fowl)
Indrashis Bhattacharya, Lakshmi K. Nalinan, K. V. Anusree, Ahmed Saleel, Aditi Khamamkar, Souvik Dey   +5 more
wiley   +1 more source

NONAROMATIZING AND AROMATIZING 19-DEMETHYLASE PRODUCTS IN THE YOLK-SAC FLUID OF THE EARLY EQUINE CONCEPTUS

, 2007
J.I. Raeside, Heather L. Christie
openalex   +1 more source

Recent innovations in crop protection research

Pest Management Science, Volume 81, Issue 5, Page 2406-2418, May 2025.
This review summarizes the latest innovations presented at the 15th IUPAC International Congress on Crop Protection Chemistry in New Delhi in 2023. New products and approaches to control insects, nematodes, diseases, and weeds are discussed, as well as recent advancements in crop enhancement and green pest management research.
Peter Maienfisch, Karsten Koerber
wiley   +1 more source

The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea, Mauro Siragusa, Ingrid Fleming   +2 more
wiley   +1 more source

Iron‐Dependent JMJD1A‐Mediated Demethylation of H3K9me2 Regulates Gene Expression During Adipogenesis in a Spatial Genome Organization‐Dependent Manner

Genes to Cells, Volume 30, Issue 3, May 2025.
JMJD1A‐mediated H3K9me2 demethylation is primarily confined to A compartments on a megabase scale during adipogenesis. Genome‐wide H3K9me2 analysis on a kilobase scale demonstrated that JMJD1A iron‐dependently targets genes involved in PPAR signaling and lipid metabolism.
Shinnosuke Masuda, Tetsuro Komatsu, Safiya Atia, Tomohiro Suzuki, Mayuko Hayashi, Atsushi Toyoda, Hiroshi Kimura, Takeshi Inagaki   +7 more
wiley   +1 more source

Drought Stress Priming Affects Tuber Yield and DNA Methylation Status in Vegetatively Propagated Potato (Solanum tuberosum L.) Plants

Journal of Agronomy and Crop Science, Volume 211, Issue 3, May 2025.
ABSTRACT Drought stress is one of the major challenges for agriculture worldwide. The cultivated potato is a tetraploid tuber propagated crop that is sensitive to drought stress. We revealed that the tuber yield in two subsequent tuber progeny generations strongly depended on the cultivar and drought‐induced memory.
Alicja Macko‐Podgórni, Jarosław Plich, Paulina Smyda‐Dajmund, Dorota Sołtys‐Kalina, Dariusz Grzebelus, Waldemar Marczewski   +5 more
wiley   +1 more source

Bromethalin Exposure in Dogs and Cats: A 14‐Year Retrospective Study (2010–2023) From the California Animal Health and Food Safety Laboratory System

Journal of Veterinary Internal Medicine, Volume 39, Issue 3, May/June 2025.
ABSTRACT Background Bromethalin, a rodenticide, is increasingly used due to restrictions on other rodenticides. Objectives The study aimed to analyze the frequency, demographics, clinical signs, and diagnostics of suspected bromethalin intoxication in dogs and cats.
Sigal Klainbart, Marcos Pérez‐López, Michael S. Filigenzi, Robert H. Poppenga   +3 more
wiley   +1 more source