Results 221 to 230 of about 7,855 (246)

Divergent MYB paralogs determine spatial distribution of linalool mediated by JA and DNA demethylation participating in aroma formation and cold tolerance of tea plants

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1455-1475, May 2025.
Summary Linalool not only is one of characteristic flavour volatiles of tea, contributing to floral aroma, but also a kind of defensive compounds, playing essential roles in resistance against biotic/abiotic stresses. Although the linalool synthases have been identified, much is unknown about the regulation mechanism in tea plants.
Rui Yue, Yaling Li, Yujia Qi, Xiaoyu Liang, Ziqing Zheng, Zhili Ye, Wei Tong, Xiongyuan Si, Yanrui Zhang, Enhua Xia, Penghui Li   +10 more
wiley   +1 more source

Harnessing haploid‐inducer mediated genome editing for accelerated maize variety development

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1604-1614, May 2025.
Summary The integration of haploid induction and genome editing, termed HI‐Edit/IMGE, is a promising tool for generating targeted mutations for crop breeding. However, the technical components and stacking suitable for the maize seed industry have yet to be fully characterised and tested.
Lina Li, Xiao Fu, Xiantao Qi, Bing Xiao, Changling Liu, Qingyu Wu, Jinjie Zhu, Chuanxiao Xie   +7 more
wiley   +1 more source

A Genome‐Wide Association Screen for Genes Affecting Leaf Trichome Development and Epidermal Metal Accumulation in Arabidopsis

Plant, Cell &Environment, Volume 48, Issue 5, Page 3708-3734, May 2025.
ABSTRACT To identify novel genes engaged in plant epidermal development, we characterized the phenotypic variability of rosette leaf epidermis of 310 sequenced Arabidopsis thaliana accessions, focusing on trichome shape and distribution, compositional characteristics of the trichome cell wall, and histologically detectable metal ion distribution.
Radek Bezvoda, Yazmín Mónica Landeo‐Ríos, Zdeňka Kubátová, Eva Kollárová, Ivan Kulich, Wolfgang Busch, Viktor Žárský, Fatima Cvrčková   +7 more
wiley   +1 more source

REIMAGINE: A central nervous system basket trial showing safety and efficacy of vafidemstat on aggression in different psychiatric disorders

Psychiatry and Clinical Neurosciences, Volume 79, Issue 5, Page 257-265, May 2025.
Aim Vafidemstat is a brain‐penetrant, orally bioavailable, small molecule irreversible inhibitor of the histone lysine‐specific demethylase KDM1A (also known as LSD1), which corrects memory deficits and behavior alterations including aggression and social interaction deficits in preclinical models.
Marc Ferrer, Vanesa Richarte, Laura Gisbert, Jordi Xaus, Sonia Gutierrez, Maria Isabel Arevalo, Michael Ropacki, Roger Bullock, Carlos Buesa, Josep Antoni Ramos‐Quiroga   +9 more
wiley   +1 more source

Host Metabolites in Asparagus–Fusarium Interaction: Mechanisms and Regulation

Plant Pathology, Volume 74, Issue 4, Page 923-942, May 2025.
Specific host metabolites regulate Fusarium pathogenicity by modulating fungal gene expression, growth, mycotoxin biosynthesis, enhancing asparagus defence responses and ultimately affecting disease severity. ABSTRACT Asparagus (Asparagus officinalis) is an important perennial vegetable crop cultivated worldwide.
Elsie Ayamoh Enow, Monika Urbaniak, Łukasz Stępień   +2 more
wiley   +1 more source

Comprehensive characterization of MCL‐1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes

International Journal of Cancer, Volume 156, Issue 8, Page 1583-1593, 15 April 2025.
What's new? MCL‐1, an anti‐apoptotic protein required for intestinal homeostasis, has been associated with chemoresistance in colorectal cancer. This study provides novel insights into the molecular profile and tumor microenvironment of colorectal cancer according to MCL‐1 mRNA expression.
Pooja Mittal, Francesca Battaglin, Yasmine Baca, Joanne Xiu, Alex Farrell, Shivani Soni, Jae Ho Lo, Lesly Torres‐Gonzalez, Sandra Algaze, Priya Jayachandran, Karam Ashouri, Alexandra Wong, Wu Zhang, Jian Yu, Lin Zhang, Benjamin A. Weinberg, Emil Lou, Anthony F. Shields, Richard M. Goldberg, John L. Marshall, Sanjay Goel, Indrakant K. Singh, Heinz‐Josef Lenz   +22 more
wiley   +1 more source

The amazing demethylase [PDF]

Nature, 1999
DNA methylation is important for repressing gene expression, and much is known about how methyl groups are added to DNA. But little has been done to work out how they're taken off again. Now, a hitherto unknown gene has been cloned, which encodes a protein that seems to catalyse demethylation by directly removing the methyl groups from 5-methyl ...
Howard Cedar, Gregory L. Verdine
openaire   +1 more source

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When Is a Demethylase Not a Demethylase?

Science Signaling, 2011
The histone lysine demethylase JARID1a has demethylase-independent function in the circadian clock.
openaire   +3 more sources

Inhibitors of histone demethylases

Bioorganic & Medicinal Chemistry, 2011
Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.
Lohse, Brian, Kristensen, Jesper L, Kristensen, Line H, Agger, Karl, Helin, Kristian, Gajhede, Michael, Clausen, Rasmus P   +6 more
openaire   +4 more sources

JMJD6 Is a Histone Arginine Demethylase

Science, 2007
Arginine methylation occurs on a number of proteins involved in a variety of cellular functions. Histone tails are known to be mono- and dimethylated on multiple arginine residues where they influence chromatin remodeling and gene expression. To date, no enzyme has been shown to reverse these regulatory modifications.
Bingsheng Chang, Richard K. Bruick, Yingming Zhao, Yue Chen   +3 more
openaire   +3 more sources