Results 231 to 240 of about 95,899 (339)

ALKBH10B Is an RNA N6-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition[OPEN]

The Plant Cell, 2017
Hong-Chao Duan, Lian-Huan Wei, Chi Zhang, Ye Wang, Lin H. Chen, Zhike Lu, Peng R. Chen, Chuan He, G. Jia   +8 more
semanticscholar   +1 more source

Intermittent Fasting Enhances Genome Integrity and Cytoprotective Pathways via (BHB) β‐Hydroxybutyrate Signaling and Chromatin Remodeling

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Repeated intermittent fasting elevates hippocampal β‐hydroxybutyrate (BHB), remodels HDAC activity and histone acetylation, and drives a metabolic–epigenetic transition from transient chromatin priming after a single fast to a sustained cytoprotective program associated with reduced DNA damage and enhanced genome maintenance.
Hadar Parnas, Joanna Bartman, Tali Rosenberg, Ronit Yosofov, Noa Gabsi, Asaf Marco   +5 more
wiley   +1 more source

KDM3A drives NSCLC proliferation and metastasis via H3K9 demethylation, EMT activation and MMP-9 upregulation. [PDF]

Biomol Biomed
Shi B, Wang Z, Xiu L, Li L, Yang X, Wang G, Li J, Wang H, Han Y.   +8 more
europepmc   +1 more source

Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs

Proceedings of the National Academy of Sciences of the United States of America, 2017
Mireya Martínez-Pérez, F. Aparicio, M. P. López-Gresa, J. Bellés, J. Sánchez-Navarro, V. Pallás   +5 more
semanticscholar   +1 more source

Structural and Functional Validation of Pseudomonas Savastanoi Ethylene Forming Enzymes Reveals Flexibility in 2‐Oxoglutarate Binding Mode and Conformation

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Studies with naturally occuring variants of the Pseudomonas savastanoi ethylene‐forming enzyme (PsEFE) inform on the effect of residues on turnover and product ratio. Crystallographic studies imply a potential for metal ion sensing. Pseudomonas savastanoi pv.
Yihong Sun, Siddhant Dhingra, Mark D. Allen, Ethan S. Z. Cheng, Zhihong Zhang, Christopher J. Schofield, Lennart Brewitz   +6 more
wiley   +1 more source

Losing is the new winning: loss of histone demethylase DT2 enhances drought stress tolerance in rice. [PDF]

Plant Physiol
Sharma G.
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, Volume 13, Issue 16, 18 March 2026.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Biochemical parallels between catabolic pathways for lignin-associated aromatic dimers. [PDF]

Appl Environ Microbiol
Michener JK.
europepmc   +1 more source

Lysine-Specific Demethylase 4C [PDF]

, 2020
openaire   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source