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CTCF and Its Multi-Partner Network for Chromatin Regulation
Cells, 2023 Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D ...
Aylin Del Moral-Morales +5 more
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The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine
Frontiers in Cell and Developmental Biology, 2022 DNA and RNA methylation dynamics have been linked to a variety of cellular processes such as development, differentiation, and the maintenance of genome integrity.
Adele Alagia, Monika Gullerova
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Molecular Cell, 2010 Histone-modifying enzymes require recruitment to specific genomic loci in order to elicit their effects. In this issue, Kleine-Kohlbrecher et al. reveal how a histone demethylase is targeted to specific genes, thereby providing mechanistic insight into recruitment and regulation.
Dawson, Mark A., Bannister, Andrew J.
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Frontiers in Plant Science, 2021 Trimethylation of histone H3 lysine 27 (H3K27me3) is a highly conserved repressive histone modification that signifies transcriptional repression in plants and animals.
Nobutoshi Yamaguchi
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Biology, 2022 Methylation at the N6-position of adenosine (N6mA) on mRNA (m6A) is one of the most widespread, highly selective and dynamically regulated RNA modifications and plays an important role in transcription and translation.
Congshan Liu +3 more
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Histone Methylation Related Therapeutic Challenge in Cardiovascular Diseases
Frontiers in Cardiovascular Medicine, 2021 The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced countries accompanied by the high prevalence of risk factors.
Yang Yang +3 more
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Histone Lysine Demethylase Inhibitors [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 The dynamic regulation of covalent modifications to histones is essential for maintaining genomic integrity and cell identity and is often compromised in cancer. Aberrant expression of histone lysine demethylases has been documented in many types of blood and solid tumors, and thus demethylases represent promising therapeutic targets.
Ashwini, Jambhekar +2 more
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The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
Frontiers in Immunology, 2022 Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses ...
Jia Yang +4 more
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Current Issues in Molecular Biology, 2023 Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan +5 more
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Association of N6-methyladenosine with viruses and virally induced diseases
Frontiers in Bioscience-Landmark, 2020 N6-methyladenosine (m6A) modification, which alters gene expression, is the most prevalent internal modification of eukaryotic mRNA. m6A modification is dynamic and reversible that is regulated by three associated protein groups: methyltransferases or ...
Fang Wu +5 more
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