Results 21 to 30 of about 765 (99)
Epigenetics, 2017 Accumulating evidence has recently shown that protein methyltransferases and demethylases are crucial regulators in either maintaining pluripotent states or inducing differentiation of embryonic stem cells. These enzymes control pluripotent signatures by
Theodore Vougiouklakis +2 more
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Current Perspectives on Histone Demethylases [PDF]
Acta Biochimica et Biophysica Sinica, 2007 The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones.
Xiaoqing, Tian, Jingyuan, Fang
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Cells, 2022 Epigenetic regulation of gene expression is crucial to the determination of cell fate in development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of proteins, acting antagonistically as complexes, play a major role in this ...
Joyce Taylor-Papadimitriou +1 more
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Histone Demethylases in Colon Cancer [PDF]
Current Colorectal Cancer Reports, 2014 Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Santanu, Paul +5 more
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Relationship between histone demethylase LSD family and development and prognosis of gastric cancer
Frontiers in Immunology, 2023 Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong +8 more
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Histone H4K20 Demethylation by Two hHR23 Proteins
Cell Reports, 2020 Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao +13 more
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AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function [PDF]
Cell Research, 2010 LSD1 (KDM1 under the new nomenclature) was the first identified lysine-specific histone demethylase belonging to the flavin-dependent amine oxidase family. Here, we report that AOF1 (KDM1B under the new nomenclature), a mammalian protein related to LSD1, also possesses histone demethylase activity with specificity for H3K4me1 and H3K4me2.
Ze, Yang +8 more
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MoleculesCurcumin-mediated anti-cancer properties have been correlated with the inhibition of oncogenic molecules such as mutp53 and c-Myc. Their targeting is therapeutically significant, as p53, following point mutations, can acquire oncogenic functions, and c ...
Roberta Santarelli +5 more
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In Vitro Histone Demethylase Assay [PDF]
Cold Spring Harbor Protocols, 2010 INTRODUCTIONPost-translational modifications of histones play an important role in regulating chromatin dynamics and function. One of the modifications, methylation, occurs on both lysine and arginine residues, and methylation status defines the epigenetic program of a cell by determining chromatin structure and thereby regulating DNA-dependent ...
Yu-ichi, Tsukada, Keiichi I, Nakayama
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A new role for histone demethylases in the maintenance of plant genome integrity
eLife, 2020 Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes.
Javier Antunez-Sanchez +17 more
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