Results 41 to 50 of about 765 (99)
Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases
Epigenetics, 2017 Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation.
Hideaki Niwa, Takashi Umehara
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Cells, 2022 Epigenetic aberrations, associated with altered DNA methylation profiles and global changes in the level of histone modifications, are commonly detected in head and neck squamous cell carcinomas (HNSCC).
Dawid Dorna, Jarosław Paluszczak
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Genome-Wide Identification of DNA Methylases and Demethylases in Kiwifruit (Actinidia chinensis)
Frontiers in Plant Science, 2020 DNA methylation plays an important role in a wide range of developmental and physiological processes in plants. It is primarily catalyzed and regulated by cytosine-5 DNA methyltransferases (C5-MTases) and a group of DNA glycosylases that act as ...
Yaoxin Zhang +12 more
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Frontiers in Cell and Developmental Biology, 2022 Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in
Mohammed Razeeth Shait Mohammed +9 more
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Histone demethylases regulate adipocyte thermogenesis [PDF]
Diabetology International, 2018 Adipocytes play a pivotal role in the regulation of energy metabolism. While white adipocyte stores energy, brown adipocyte dissipates energy by producing heat. In addition, another type of heat-producing adipocyte, beige adipocyte, emerges in white adipose tissue in response to chronic coldness.
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Detailed resume of RNA m6A demethylases
Acta Pharmaceutica Sinica B, 2022 N6-Methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, m6A modification can be catalyzed by the methyltransferase complex and erased ...
Dandan Shen +13 more
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Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets
Pharmaceuticals, 2012 The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles.
Jeison Garcia, Fernando Lizcano
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Chemical Biology of Lysine Demethylases [PDF]
Current Chemical Genomics, 2011 Abnormal levels of DNA methylation and/or histone modifications are observed in patients with a wide variety of chronic diseases. Methylation of lysines within histone tails is a key modification that contributes to increased gene expression or repression depending on the specific residue and degree of methylation, which is in turn controlled by the ...
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Discovery and structural studies of histone demethylases
Frontiers in Epigenetics and EpigenomicsThe discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identification of ...
Longfei Peng +5 more
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Journal of Lipid Research, 2001 Sterol 14α-demethylase (14DM) is a cytochrome P-450 involved in sterol biosynthesis in eukaryotes. It was reported that Mycobacterium smegmatis also makes cholesterol and that cholesterol is essential to Mycobacterium tuberculosis (MT) infection ...
Aouatef Bellamine +4 more
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