Results 51 to 60 of about 765 (99)
Expression and significance of histone H3K27 demethylases in renal cell carcinoma
BMC Cancer, 2012 Background The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin. Previous studies have indicated an abnormal H3K27 methylation status in carcinogenesis. We
Shen Yongqing +6 more
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Histone Demethylases in Cancer [PDF]
Current Pharmacology Reports, 2015 Epigenetic regulation, which involves with covalent modifications of DNA and the protein that bundles DNA, namely histones, is an exciting and variable phenomenon that affects normal cellular genetic character and contributes to human diseases. One key histone modification is methylation, regulated by methyl transferases and demethylases.
Satheesh Sainathan +5 more
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PLoS ONE, 2010 BackgroundSmall molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents.
Oliver N F King +16 more
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Functions of RNA N6-Methyladenosine Demethylases in Plant Development and Stress Responses
AgronomyN6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, regulates gene expression by modulating mRNA metabolism. Demethylases (“erasers”) specifically remove these m6A marks. In mammals, FTO and ALKBH5 (ALKBH family members)
Ran Su +5 more
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Current Issues in Molecular BiologyHistone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the role and therapeutic potential of HDM in CRC.
Yuanbin Liu +3 more
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HEPATIC AMINOPYRINE N-DEMETHYLASE SYSTEM: EFFECT OF CYANIDE ON MICROSOMAL N-DEMETHYLASE ACTIVITY
Japanese Journal of Pharmacology, 1977 Cyanide, an inhibitor of many hemoproteins, was shown to affect a number of microsomal drug-metabolizing activities catalyzed by cytochrome P-450. The N-demethylation reaction of aminopyrine was inhibited noncompetitively by this inhibitor in microsomal preparations from rats.
T, Matsubara, A, Touchi
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Asian Journal of AndrologySpermatogenesis is a fundamental process that requires a tightly controlled epigenetic event in spermatogonial stem cells (SSCs). The mechanisms underlying the transition from SSCs to sperm are largely unknown.
Shan Li +11 more
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Roles of KDM5 demethylases in therapeutic resistance of cancers
Epigenetics & ChromatinEpigenetic modifications, including the regulation of histone H3 lysine 4 methylation (H3K4me2/3), play critical roles in maintaining normal tissue homeostasis and influencing the progression of cancer, including growth, invasion, metastasis, and ...
Xiaobo Chen +7 more
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AntioxidantsImbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates the development of osteoporosis, which is the leading risk factor of disability in the elderly.
Wei-Shiung Lian +5 more
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Histone demethylases in autophagy and inflammation
Cell Communication and SignalingAutophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase,
Yaoyao Ma +15 more
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