Demethylases - Open Access .click

Bioorganic & Medicinal Chemistry, 2011
Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.
Lohse, Brian +6 more
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JmjC Lysine Demethylases

2015
Among the most fundamental questions in the regulation of gene expression in mammals is how epigenetic methylation patterns of histone lysine residues are established, recognized and erased. This chapter reviews recent studies on, and discusses the resulting biochemical and structural insights into, the Jumonji C (JmjC)-containing lysine demethylases ...
Xiaodong Cheng, Raymond C. Trievel
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In Vitro Histone Demethylase Assays

2022
Dynamic histone methylation regulates gene activation and repression. It is involved in proliferation, differentiation, lineage specification, and development. Histone demethylase assays are invaluable in studying histone demethylation substrate recognition, kinetics, regulation, and inhibition by small molecules, many of which are potential ...
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histone demethylases
3. good health
epigenetics

animals
humans
histones

oxidoreductases, n-demethylating
methylation
methyltransferases