Results 191 to 200 of about 97,922 (342)

Dysregulation of the endosomal sorting complex III is linked to neurodegeneration in progressive multiple sclerosis

Brain Pathology, EarlyView.
This study shows that components of the ESCRT‐III membrane repair machinery, VPS4B and CHMP2A, are dysregulated in progressive MS and are associated with higher neurodegeneration and inflammation. This might lead to improper function of the complex to inhibit the final stages of necroptosis activation and thus impede neuronal cell death.
Carmen Picon, Robertas Aleksynas, Marcelina Wojewska, Francesco de Virgiliis, Doron Merkler, Richard Reynolds   +5 more
wiley   +1 more source

Oligodendrocyte-Specific Mechanisms of Myelin Thinning: Implications for Neurodegenerative Diseases

Frontiers in Neuroscience, 2021
Monokesh K. Sen, Monokesh K. Sen, Md Jakir Hossain   +2 more
doaj   +1 more source

Biochemically altered myelin triggers autoimmune demyelination

Proceedings of the National Academy of Sciences of the United States of America, 2018
A. Caprariello, James A. Rogers, M. Morgan, Vahid Hoghooghi, Jason R. Plemel, Adam Koebel, S. Tsutsui, J. Dunn, L. Kotra, S. Ousman, V. Wee Yong, P. Stys   +11 more
semanticscholar   +1 more source

Demyelination Induced by Murine Coronavirus JHM Infection of Congenitally Immunodeficient Mice

, 1995
Jacqueline J Houtman, Harry C. Hinze, J. O. Fleming   +2 more
openalex   +1 more source

Effect of time to initiation and dose of methylprednisolone on outcome in multiple sclerosis‐related optic neuritis

Clinical and Experimental Neuroimmunology, EarlyView.
Abstract Objectives It is known that the benefit of intravenous methylprednisolone (IVMP) in multiple sclerosis‐related optic neuritis (MS‐ON) is limited to an accelerated recovery. We aimed to evaluate the impact of time from symptoms onset to IVMP initiation and of IVMP dose on visual recovery among people with MS‐ON.
Hadar Gilad, Josepha Horowitz, Sivan Bloch, Daniel Golan   +3 more
wiley   +1 more source

Acute Demyelination, Neuropathological Diagnosis, and Clinical Evolution [PDF]

, 2000
D. Annesley-Williams, Michael A. Farrell, Hugh Staunton, Francesca Brett   +3 more
openalex   +1 more source

Dysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury

Cell Proliferation, EarlyView.
Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu   +15 more
wiley   +1 more source

TREM2 sustains microglial expansion during aging and response to demyelination.

Journal of Clinical Investigation, 2015
P. L. Poliani, Yaming Wang, E. Fontana, M. Robinette, Y. Yamanishi, S. Gilfillan, M. Colonna   +6 more
semanticscholar   +1 more source

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

, 1998
Cynthia Rivera-Quiñones, Dorian B. McGavern, James D. Schmelzer, Samuel F. Hunter, Phillip A. Low, Moses Rodriguez   +5 more
openalex   +2 more sources

Cytokine gene therapy of autoimmune demyelination revisited using herpes simplex virus type-1-derived vectors [PDF]

, 2000
Gianvito Martino, Pietro Luigi Poliani, Peggy Marconi, Gıancarlo Comı, Roberto Furlan   +4 more
openalex   +1 more source