Results 11 to 20 of about 11,205,379 (410)
Deciphering the combinatorial landscape of immunity
eLife, 2020 From cellular activation to drug combinations, immunological responses are shaped by the action of multiple stimuli. Synergistic and antagonistic interactions between stimuli play major roles in shaping immune processes.
Antonio Cappuccio +5 more
doaj +1 more source
Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]
PLoS ONE, 2013 Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda +9 more
doaj +1 more source
Regulation of the Migration of Distinct Dendritic Cell Subsets
Frontiers in Cell and Developmental Biology, 2021 Dendritic cells (DCs), a class of antigen-presenting cells, are widely present in tissues and apparatuses of the body, and their ability to migrate is key for the initiation of immune activation and tolerogenic immune responses.
Meng Feng +5 more
doaj +1 more source
Dendritic cell metabolism [PDF]
Nature Reviews Immunology, 2014 The past 15 years have seen enormous advances in our understanding of the receptor and signalling systems that allow dendritic cells (DCs) to respond to pathogens or other danger signals and initiate innate and adaptive immune responses. We are now beginning to appreciate that many of these pathways not only stimulate changes in the expression of genes
Pearce, E.J., Everts, B.
openaire +5 more sources
OVA-PEG-R848 nanocapsules stimulate neonatal conventional and plasmacytoid dendritic cells
Frontiers in Pediatrics, 2022 Childhood mortality represents a major issue with 5. 3 million worldwide deaths of children under 5 years of age in 2019. Approximately half of those deaths can be attributed to easily preventable, infectious diseases.
Sebastian Wirsching +12 more
doaj +1 more source
Manufacturing Dendritic Cells for Immunotherapy: Monocyte Enrichment [PDF]
, 2020 Dendritic cells play a key role in activation of the immune system as potent antigen-presenting cells. This pivotal position, along with the ability to generate dendritic cells from monocytes and ready uptake of antigen, makes them an intriguing vehicle ...
Cox, Cheryl, Hopewell, Emily L.
core +1 more source
Nature Communications, 2020 Immune checkpoint blockade therapies have shown clinical promise in a variety of cancers, but how tumor-infiltrating T cells are activated remains unclear. In this study, we explore the functions of PD-L1 on dendritic cells (DCs), which highly express PD-
Qing Peng +10 more
semanticscholar +1 more source
Dendritic Cells and Their Role in Immunotherapy
Frontiers in Immunology, 2020 Despite significant advances in the field of cancer immunotherapy, the majority of patients still do not benefit from treatment and must rely on traditional therapies.
Alycia Gardner +2 more
semanticscholar +1 more source
Bio-Protocol, 2023 Dendritic cells have been investigated for cell-based immunotherapy for various applications. The low abundance of dendritic cells in blood hampers their clinical application, resulting in the use of monocyte-derived dendritic cells as an alternative ...
Georgina Flórez-Grau +7 more
doaj +1 more source
eLife, 2018 Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I producing ...
Brian Webster +12 more
doaj +1 more source