Results 21 to 30 of about 11,507,286 (389)

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

Journal of Experimental Medicine, 1994
Using granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 we have established dendritic cell (DC) lines from blood mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic ...
F. Sallusto, A. Lanzavecchia
semanticscholar   +1 more source

Dendritic Cells and Their Role in Immunotherapy

Frontiers in Immunology, 2020
Despite significant advances in the field of cancer immunotherapy, the majority of patients still do not benefit from treatment and must rely on traditional therapies.
Alycia Gardner, Alvaro de Mingo Pulido, B. Ruffell   +2 more
semanticscholar   +1 more source

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

Journal of Experimental Medicine, 1992
Antigen-presenting, major histocompatibility complex (MHC) class II- rich dendritic cells are known to arise from bone marrow. However, marrow lacks mature dendritic cells, and substantial numbers of proliferating less-mature cells have yet to be ...
K. Inaba, M. Inaba, N. Romani, Hideki Aya, Masashi Deguchi, S. Ikehara, S. Muramatsu, Ralph M. Steinmanll   +7 more
semanticscholar   +1 more source

Dendritic Cells and Their Multiple Roles during Malaria Infection

Journal of Immunology Research, 2016
Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial ...
Kelly N. S. Amorim, Daniele C. G. Chagas, Fernando B. Sulczewski, Silvia B. Boscardin   +3 more
doaj   +1 more source

Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity

Cell Reports, 2020
Summary: Human dendritic cells (DCs) comprise subsets with distinct phenotypic and functional characteristics, but the transcriptional programs that dictate their identity remain elusive.
Rebecca Leylek, Marcela Alcántara-Hernández, Jeffrey M. Granja, Michael Chavez, Kimberly Perez, Oscar R. Diaz, Rui Li, Ansuman T. Satpathy, Howard Y. Chang, Juliana Idoyaga   +9 more
doaj   +1 more source

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

eLife, 2015
Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV)
Cécile Alanio, Francesco Nicoli, Philippe Sultanik, Tobias Flecken, Brieuc Perot, Darragh Duffy, Elisabetta Bianchi, Annick Lim, Emmanuel Clave, Marit M van Buuren, Aurélie Schnuriger, Kerstin Johnsson, Jeremy Boussier, Antoine Garbarg-Chenon, Laurence Bousquet, Estelle Mottez, Ton N Schumacher, Antoine Toubert, Victor Appay, Farhad Heshmati, Robert Thimme, Stanislas Pol, Vincent Mallet, Matthew L Albert   +23 more
doaj   +1 more source

Efferocytosis promotes suppressive effects on dendritic cells through prostaglandin E2 production in the context of autoimmunity. [PDF]

PLoS ONE, 2013
INTRODUCTION: Efferocytosis is a crucial process by which apoptotic cells are cleared by phagocytes, maintaining immune tolerance to self in the absence of inflammation.
Irma Pujol-Autonell, Rosa-Maria Ampudia, Raquel Planas, Silvia Marin-Gallen, Jorge Carrascal, Alex Sanchez, Ana Marin, Manuel Puig-Domingo, Ricardo Pujol-Borrell, Joan Verdaguer, Marta Vives-Pi   +10 more
doaj   +1 more source

Dendritic cells in plasmodium infection [PDF]

, 2008
Infection with Plasmodium parasites (malaria) contributes greatly to morbidity and mortality in affected areas. Interaction of the protozoan with the immune system has a critical role in the pathogenesis of the disease, but may also hold a key to ...
Alonso, Bejon, Britta C Urban, Bruna-Romero, deWalick, Greenwood, Park, Patel, Perry, Pichyangkul, Pouniotis, Skorokhod, Stephen M Todryk, Todryk, Wong, Wykes   +15 more
core   +2 more sources

From secretome analysis to immunology: chitosan induces major alterations in the activation of dendritic cells via a TLR4-dependent mechanism [PDF]

, 2009
Dendritic cells are known to be activated by a wide range of microbial products, leading to cytokine production and increased levels of membrane markers such as major histocompatibility complex class II molecules.
Arora, Behrens, Bellocchio, Berthier, Bittencourt, Chang, Chevallet, Chevallet, Chieppa, Curtsinger, de Saint-Vis, Dillon, Elliott, Faure, Gallucci, Gharahdaghi, Goetz, Johnson, Jørgensen, Kawai, Kennedy, Levitz, Luche, Maldonado-López, Murray, Owhashi, Peng, Perkins, Porporatto, Rabilloud, Rabilloud, Rabilloud, Richert, Romani, Seong, Shibata, Tada, Termeer, Underhill, Verhasselt, Wang, Yang, Young   +42 more
core   +5 more sources

The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

Journal for ImmunoTherapy of Cancer, 2019
Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a ...
Kalijn F. Bol, Gerty Schreibelt, Katrin Rabold, Stefanie K. Wculek, Julia Katharina Schwarze, Andrzej Dzionek, Alvaro Teijeira, Lana E. Kandalaft, Pedro Romero, George Coukos, Bart Neyns, David Sancho, Ignacio Melero, I. Jolanda M. de Vries   +13 more
doaj   +1 more source