Efferocytosis promotes suppressive effects on dendritic cells through prostaglandin E2 production in the context of autoimmunity. [PDF]
PLoS ONE, 2013 INTRODUCTION: Efferocytosis is a crucial process by which apoptotic cells are cleared by phagocytes, maintaining immune tolerance to self in the absence of inflammation.
Irma Pujol-Autonell +10 more
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Tolerogenic Dendritic Cells [PDF]
Annual Review of Immunology, 2003 ▪ Abstract Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells.
Steinman, Ralph M. +2 more
openaire +2 more sources
Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients
eLife, 2015 Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV)
Cécile Alanio +23 more
doaj +1 more source
The dendritic cell niche in chronic obstructive pulmonary disease. [PDF]
, 2012 The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD).
Haczku, Angela
core +3 more sources
The clinical application of cancer immunotherapy based on naturally circulating dendritic cells
Journal for ImmunoTherapy of Cancer, 2019 Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a ...
Kalijn F. Bol +13 more
doaj +1 more source
Dendritic cells in plasmodium infection [PDF]
, 2008 Infection with Plasmodium parasites (malaria) contributes greatly to morbidity and mortality in affected areas. Interaction of the protozoan with the immune system has a critical role in the pathogenesis of the disease, but may also hold a key to ...
Alonso +15 more
core +2 more sources
Autophagy in dendritic cells [PDF]
Cellular & Molecular Immunology, 2018 Autophagy and immunity share the property of being auto-protective for the organism. Autophagy is an important degradation pathway that buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. Perturbations in autophagy are associated with inflammation and cancer development.
Ghislat, G., Lawrence, T.
openaire +4 more sources
From secretome analysis to immunology: chitosan induces major alterations in the activation of dendritic cells via a TLR4-dependent mechanism [PDF]
, 2009 Dendritic cells are known to be activated by a wide range of microbial products, leading to cytokine production and increased levels of membrane markers such as major histocompatibility complex class II molecules.
Arora +42 more
core +5 more sources
Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]
, 2020 The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia +4 more
core +2 more sources
The role of CD103+ Dendritic cells in the intestinal mucosal immune system.
Frontiers in Immunology, 2011 While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal
Darren Thomas Ruane, Ed Charles Lavelle
doaj +1 more source