Results 1 to 10 of about 591,136 (270)

Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins

Cells, 2021
Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2–8 ...
Pushpa Khanal, Pirta Hotulainen
doaj   +2 more sources

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density. [PDF]

PLoS ONE, 2016
The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuronal structure and function. Although these receptors share common signaling pathways, they are capable of having distinct effects on cellular plasticity ...
Kellie S Gross, Dieter D Brandner, Luis A Martinez, M Foster Olive, Robert L Meisel, Paul G Mermelstein   +5 more
doaj   +2 more sources

Effects of Tropomodulin 2 on Dendritic Spine Reorganization and Dynamics [PDF]

Biomolecules, 2023
Dendritic spines are actin-rich protrusions that receive a signal from the axon at the synapse. Remodeling of cytoskeletal actin is tightly connected to dendritic spine morphology-mediated synaptic plasticity of the neuron.
Balaganesh Kuruba, Nickolas Starks, Mary Rose Josten, Ori Naveh, Gary Wayman, Marina Mikhaylova, Alla S. Kostyukova   +6 more
doaj   +2 more sources

Dendritic Spine and Synaptic Plasticity in Alzheimer’s Disease: A Focus on MicroRNA

Frontiers in Cell and Developmental Biology, 2020
Dendrites and dendritic spines are dynamic structures with pivotal roles in brain connectivity and have been recognized as the locus of long-term synaptic plasticity related to cognitive processes such as learning and memory.
Edwin Estefan Reza-Zaldivar, Mercedes Azucena Hernández-Sápiens, Benito Minjarez, Ulises Gómez-Pinedo, Victor Javier Sánchez-González, Ana Laura Márquez-Aguirre, Ana Laura Márquez-Aguirre, Alejandro Arturo Canales-Aguirre, Alejandro Arturo Canales-Aguirre   +8 more
doaj   +2 more sources

Co-exposure to low-dose lead, cadmium, and mercury promotes memory deficits in rats: Insights from the dynamics of dendritic spine pruning in brain development

Ecotoxicology and Environmental Safety, 2023
Lead (Pb), cadmium (Cd), and mercury (Hg) are environmentally toxic heavy metals that can be simultaneously detected at low levels in the blood of the general population. Although our previous studies have demonstrated neurodevelopmental toxicity upon co-
Fankun Zhou, Lu Ouyang, Jie Xie, Sisi Liu, Qi Li, Shuo Yang, Jiajun Li, Rui Su, Shaoqi Rao, Lingyu Yan, Xin Wan, Hui Cheng, Peishan Liu, Lingling Li, Yanhui Zhu, Guihua Du, Chang Feng, Guangqin Fan   +17 more
doaj   +2 more sources

Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons [PDF]

Scientific Reports
Adults and children with cholestatic liver disease are at risk for type C hepatic encephalopathy (HE) and may present lifelong neurocognitive impairment.
Laurianne Giovannoni, Katarzyna Pierzchala, Mathias De Roo, Olivier Braissant, Stephen Bruce, Valérie Anne McLin, Laszlo Vutskits   +6 more
doaj   +2 more sources

Astrocyte-Secreted Lcn2 Modulates Dendritic Spine Morphology. [PDF]

Cells
Doliwa M, Kuzniewska B, Nader K, Reniewicz P, Kaczmarek L, Michaluk P, Kalita K.   +6 more
europepmc   +3 more sources

Dendritic spine degeneration is associated with age-related decline in recognition and spatial memory in male mice. [PDF]

Brain Struct Funct
Monroy E, Aguilar-Hernandez L, de la Cruz-López F, Flores G, Morales-Medina JC.   +4 more
europepmc   +3 more sources

Neurodevelopmental disorder-associated ZBTB20 gene variants affect dendritic and synaptic structure. [PDF]

PLoS ONE, 2018
Dendritic spine morphology and dendritic arborization are key determinants of neuronal connectivity and play critical roles in learning, memory and behavior function.
Kelly A Jones, Yue Luo, Lynn Dukes-Rimsky, Deepak P Srivastava, Richa Koul-Tewari, Theron A Russell, Lauren P Shapiro, Anand K Srivastava, Peter Penzes   +8 more
doaj   +1 more source

Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an "all-or-nothing" communication switch between the spine head and dendrite.

PLoS Computational Biology, 2022
Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle ...
James Rosado, Viet Duc Bui, Carola A Haas, Jürgen Beck, Gillian Queisser, Andreas Vlachos   +5 more
doaj   +1 more source