Results 11 to 20 of about 87,585 (230)
Lipid dynamics at dendritic spines [PDF]
Frontiers in Neuroanatomy, 2014 Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine plasticity.
Dotti, Carlos G. +2 more
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Cells, 2021 Dendritic spines are small, thin, hair-like protrusions found on the dendritic processes of neurons. They serve as independent compartments providing large amplitudes of Ca2+ signals to achieve synaptic plasticity, provide sites for newer synapses ...
Arehally M. Mahalakshmi +8 more
doaj +1 more source
Signaling in dendritic spines and spine microdomains [PDF]
Current Opinion in Neurobiology, 2012 The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical ...
Bernardo L. Sabatini, Yao Chen
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Scientific Reports, 2021 A major complication with spinal cord injury (SCI) is the development of spasticity, a clinical symptom of hyperexcitability within the spinal H-reflex pathway.
Curtis A. Benson +7 more
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The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. [PDF]
, 2015 The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process.
Gdalyahu, Amos +5 more
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Dendritic Spine Plasticity and Cognition [PDF]
Neural Plasticity, 2012 The scientific studies of dendritic spines have experienced an overwhelming growth in the last three decades. Since the primary concept that dendritic spines are sites of excitatory synaptic contact, the most recent studies have led to theoretical proposals that relate spines' morphophysiology with the information processing that underlies cognition ...
Irina Nikonenko +2 more
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eLife, 2022 Dendritic spines are the central postsynaptic machinery that determines synaptic function. The F-actin within dendritic spines regulates their dynamic formation and elimination.
Soo Jeong Kim +9 more
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Diffusion laws in dendritic spines [PDF]
The Journal of Mathematical Neuroscience, 2011 Dendritic spines are small protrusions on a neuronal dendrite that are the main locus of excitatory synaptic connections. Although their geometry is variable over time and along the dendrite, they typically consist of a relatively large head connected to the dendritic shaft by a narrow cylindrical neck.
David Holcman +2 more
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The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]
, 2016 Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F. +12 more
core +1 more source
The spine problem: finding a function for dendritic spines [PDF]
Frontiers in Neuroanatomy, 2014 Why do neurons have dendritic spines? This question-the heart of what Yuste calls "the spine problem"-presupposes that why-questions of this sort have scientific answers: that empirical findings can favor or count against claims about why neurons have spines. Here we show how such questions can receive empirical answers.
Sarah Malanowski, Carl F. Craver
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