Results 11 to 20 of about 591,136 (270)
Cadherin Regulates Dendritic Spine Morphogenesis [PDF]
Neuron, 2002 Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons.
Hideru Togashi +5 more
openalex +3 more sources
Superresolving Dendritic Spines [PDF]
Biophysical Journal, 2013 Spines are tiny protrusions that densely stud the dendrites of neurons in the brain. Individual spines are the primary recipients of synaptic inputs from single axons, which emanate from other neurons in the central nervous system. A dendritic tree on one neuron may have hundreds of thousands of spines, making connections to a corresponding number of ...
Loew, Leslie M., Hell, Stefan
openaire +5 more sources
Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. [PDF]
PLoS ONE, 2015 During development, scaffold proteins serve as important platforms for orchestrating signaling complexes to transduce extracellular stimuli into intracellular responses that regulate dendritic spine morphology and function.
Yu Chen +8 more
doaj +1 more source
REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex
Nature Communications, 2020 In many parts of the nervous system, experience-dependent refinement of neuronal circuits predominantly involves synapse elimination. The role of sleep in this process remains unknown.
Yanmei Zhou +7 more
semanticscholar +1 more source
Dendritic Spine Plasticity: Function and Mechanisms
Frontiers in Synaptic Neuroscience, 2020 Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888 by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of electron microscopy (EM) confirmed Cajal’s intuition that spines ...
Karen Runge +2 more
semanticscholar +1 more source
Cells, 2021 Dendritic spines are small, thin, hair-like protrusions found on the dendritic processes of neurons. They serve as independent compartments providing large amplitudes of Ca2+ signals to achieve synaptic plasticity, provide sites for newer synapses ...
Arehally M. Mahalakshmi +8 more
doaj +1 more source
Scientific Reports, 2021 A major complication with spinal cord injury (SCI) is the development of spasticity, a clinical symptom of hyperexcitability within the spinal H-reflex pathway.
Curtis A. Benson +7 more
doaj +1 more source
The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. [PDF]
, 2015 The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process.
Gdalyahu, Amos +5 more
core +9 more sources
eLife, 2022 Dendritic spines are the central postsynaptic machinery that determines synaptic function. The F-actin within dendritic spines regulates their dynamic formation and elimination.
Soo Jeong Kim +9 more
doaj +1 more source
The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]
, 2016 Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F. +12 more
core +1 more source