Frontiers in Cellular Neuroscience, 2017 Psychostimulant drugs of abuse increase dendritic spine density in reward centers of the brain. However, little is known about their effects in the hippocampus, where activity-dependent changes in the density of dendritic spine are associated with ...
Soledad Ferreras +13 more
doaj +1 more source
Cell Reports, 2014 Sensory experience regulates the development of various brain structures, including the cortex, hippocampus, and olfactory bulb (OB). Little is known about how sensory experience regulates the dendritic spine development of OB interneurons, such as ...
Sei-ichi Yoshihara +11 more
doaj +1 more source
Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus. [PDF]
PLoS Computational Biology, 2014 Temporal lobe epilepsy strongly affects hippocampal dentate gyrus granule cells morphology. These cells exhibit seizure-induced anatomical alterations including mossy fiber sprouting, changes in the apical and basal dendritic tree and suffer substantial ...
Julian Tejada +2 more
doaj +1 more source
Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework [PDF]
, 2005 The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we
Coombes, Stephen +2 more
core +2 more sources
Reaction–Diffusion Model-Based Research on Formation Mechanism of Neuron Dendritic Spine Patterns
Frontiers in Neurorobotics, 2021 The pattern abnormalities of dendritic spine, tiny protrusions on neuron dendrites, have been found related to multiple nervous system diseases, such as Parkinson's disease and schizophrenia.
Yiqing Jia +6 more
doaj +1 more source
Early intervention combined with targeted treatment promotes cognitive and behavioral improvements in young children with fragile x syndrome. [PDF]
, 2012 Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of the FMR1 gene leading to gene silencing.
Borodyanskara, Mariya +3 more
core +3 more sources
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 [PDF]
, 2016 Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage.
Abel, Ted +14 more
core +5 more sources
Calcium Dynamics in Dendritic Spines and Spine Motility [PDF]
Biophysical Journal, 2004 A dendritic spine is an intracellular compartment in synapses of central neurons. The role of the fast twitching of spines, brought about by a transient rise of internal calcium concentration above that of the parent dendrite, has been hitherto unclear.
David Holcman +2 more
openaire +3 more sources
Frontiers in Cellular Neuroscience, 2018 Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD).
Iryna Hlushchenko +7 more
doaj +1 more source
Dendritic Spine Shape Analysis: A Clustering Perspective [PDF]
, 2016 Functional properties of neurons are strongly coupled with their morphology. Changes in neuronal activity alter morphological characteristics of dendritic spines.
A Govindarajan +30 more
core +2 more sources