Results 21 to 30 of about 94,485 (200)

ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2018
Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD).
Iryna Hlushchenko, Pushpa Khanal, Amr Abouelezz, Amr Abouelezz, Amr Abouelezz, Ville O. Paavilainen, Ville O. Paavilainen, Pirta Hotulainen   +7 more
doaj   +1 more source

Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation [PDF]

, 2013
Dendritic spines are major sites of excitatory synaptic transmission and changes in their numbers and morphology have been associated with neurodevelopmental and neurodegenerative disorders.
Galati, DF, Hiester, BG, Jones, KR, Salinas, PC   +3 more
core   +1 more source

Neurodevelopmental disorder-associated ZBTB20 gene variants affect dendritic and synaptic structure.

PLoS ONE, 2018
Dendritic spine morphology and dendritic arborization are key determinants of neuronal connectivity and play critical roles in learning, memory and behavior function.
Kelly A Jones, Yue Luo, Lynn Dukes-Rimsky, Deepak P Srivastava, Richa Koul-Tewari, Theron A Russell, Lauren P Shapiro, Anand K Srivastava, Peter Penzes   +8 more
doaj   +1 more source

Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

Neurobiology of Disease, 2009
Rett syndrome (RTT) is an X chromosome-linked neurodevelopmental disorder associated with the characteristic neuropathology of dendritic spines common in diseases presenting with mental retardation (MR).
Christopher A. Chapleau, Gaston D. Calfa, Meredith C. Lane, Asher J. Albertson, Jennifer L. Larimore, Shinichi Kudo, Dawna L. Armstrong, Alan K. Percy, Lucas Pozzo-Miller   +8 more
doaj   +1 more source

Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability [PDF]

, 2015
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Smolen, Paul
core   +4 more sources

Lamina-specific AMPA receptor dynamics following visual deprivation in vivo. [PDF]

, 2020
Regulation of AMPA receptor (AMPAR) expression is central to synaptic plasticity and brain function, but how these changes occur in vivo remains elusive.
Cudmore, Robert H, Graves, Austin R, Huganir, Richard L, Roth, Richard H, Tan, Han L   +4 more
core   +2 more sources

ApoE receptor 2 regulates synapse and dendritic spine formation.

PLoS ONE, 2011
BackgroundApolipoprotein E receptor 2 (ApoEr2) is a postsynaptic protein involved in long-term potentiation (LTP), learning, and memory through unknown mechanisms.
Sonya B Dumanis, Hyun-Jung Cha, Jung Min Song, Justin H Trotter, Matthew Spitzer, Ji-Yun Lee, Edwin J Weeber, R Scott Turner, Daniel T S Pak, G William Rebeck, Hyang-Sook Hoe   +10 more
doaj   +1 more source

Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning [PDF]

, 2013
The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the number of total and
Calfa, Gaston Diego, Giachero, Marcelo, Molina, Víctor Alejandro   +2 more
core   +1 more source

Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease

Neural Plasticity, 2012
Synapses are sites of cell-cell contacts that transmit electrical or chemical signals in the brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are located.
Wendou Yu, Bingwei Lu
doaj   +1 more source

Chronic low-dose Δ9-tetrahydrocannabinol (THC) treatment stabilizes dendritic spines in 18-month-old mice

Scientific Reports, 2023
Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine dynamics. Previously, we have shown that a low dose chronic THC treatment improves learning abilities in old whereas impairs ...
Joanna Agnieszka Komorowska-Müller, Anne-Kathrin Gellner, Kishore Aravind Ravichandran, Andras Bilkei-Gorzo, Andreas Zimmer, Valentin Stein   +5 more
doaj   +1 more source