Results 31 to 40 of about 591,136 (270)

ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2018
Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD).
Iryna Hlushchenko, Pushpa Khanal, Amr Abouelezz, Amr Abouelezz, Amr Abouelezz, Ville O. Paavilainen, Ville O. Paavilainen, Pirta Hotulainen   +7 more
doaj   +1 more source

Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning [PDF]

, 2013
The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the number of total and
Calfa, Gaston Diego, Giachero, Marcelo, Molina, Víctor Alejandro   +2 more
core   +1 more source

Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation [PDF]

, 2013
Dendritic spines are major sites of excitatory synaptic transmission and changes in their numbers and morphology have been associated with neurodevelopmental and neurodegenerative disorders.
Galati, DF, Hiester, BG, Jones, KR, Salinas, PC   +3 more
core   +1 more source

Lamina-specific AMPA receptor dynamics following visual deprivation in vivo. [PDF]

, 2020
Regulation of AMPA receptor (AMPAR) expression is central to synaptic plasticity and brain function, but how these changes occur in vivo remains elusive.
Cudmore, Robert H, Graves, Austin R, Huganir, Richard L, Roth, Richard H, Tan, Han L   +4 more
core   +2 more sources

Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

Neurobiology of Disease, 2009
Rett syndrome (RTT) is an X chromosome-linked neurodevelopmental disorder associated with the characteristic neuropathology of dendritic spines common in diseases presenting with mental retardation (MR).
Christopher A. Chapleau, Gaston D. Calfa, Meredith C. Lane, Asher J. Albertson, Jennifer L. Larimore, Shinichi Kudo, Dawna L. Armstrong, Alan K. Percy, Lucas Pozzo-Miller   +8 more
doaj   +1 more source

Calcium Signaling in Dendritic Spines [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Calcium (Ca(2+)) is a ubiquitous signaling molecule that accumulates in the cytoplasm in response to diverse classes of stimuli and, in turn, regulates many aspects of cell function. In neurons, Ca(2+) influx in response to action potentials or synaptic stimulation triggers neurotransmitter release, modulates ion channels, induces synaptic plasticity ...
Michael J. Higley, Bernardo L. Sabatini
openalex   +3 more sources

Dendritic pathology, spine loss and synaptic reorganization in human cortex from epilepsy patients.

Brain : a journal of neurology, 2020
Neuronal dendritic arborizations and dendritic spines are crucial for a normal synaptic transmission and may be critically involved in the pathophysiology of epilepsy.
Laura Rossini, Dalia De Santis, Roberta Mauceri, C. Tesoriero, M. Bentivoglio, E. Maderna, A. Maiorana, F. Deleo, M. de Curtis, G. Tringali, M. Cossu, G. Tumminelli, M. Bramerio, R. Spreafico, L. Tassi, R. Garbelli   +15 more
semanticscholar   +1 more source

Travelling waves in a model of quasi-active dendrites with active spines [PDF]

, 2010
Dendrites, the major components of neurons, have many different types of branching structures and are involved in receiving and integrating thousands of synaptic inputs from other neurons.
Abbott, Alvarez, Baer, Bhatt, Bloodgood, Bressloff, Brown, Cajal, Cook, Coombes, Coombes, Coombes, Coombes, Coombes, Cox, Hodgkin, James, Johnston, Katz, Koch, Larkum, Lord, Magee, Mauro, Mel, Miller, Miller, Narayanan, Scott, Segal, Segev, Shepherd, Spruston, Svoboda, Timofeeva, Timofeeva, Timofeeva, Tsay, Ulrich, Williams, Y. Timofeeva   +40 more
core   +1 more source

Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

Nature Communications, 2018
Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient mechanism of information storage in cortical circuits.
Adam Frank, Shan Huang, Miou Zhou, A. Gdalyahu, George Kastellakis, Tawnie K Silva, Elaine Lu, Ximiao Wen, Panayiota Poirazi, J. Trachtenberg, Alcino J. Silva   +10 more
semanticscholar   +1 more source

ApoE receptor 2 regulates synapse and dendritic spine formation.

PLoS ONE, 2011
BackgroundApolipoprotein E receptor 2 (ApoEr2) is a postsynaptic protein involved in long-term potentiation (LTP), learning, and memory through unknown mechanisms.
Sonya B Dumanis, Hyun-Jung Cha, Jung Min Song, Justin H Trotter, Matthew Spitzer, Ji-Yun Lee, Edwin J Weeber, R Scott Turner, Daniel T S Pak, G William Rebeck, Hyang-Sook Hoe   +10 more
doaj   +1 more source