Results 41 to 50 of about 591,136 (270)
Dendritic Spine Shape Analysis: A Clustering Perspective [PDF]
, 2016 Functional properties of neurons are strongly coupled with their morphology. Changes in neuronal activity alter morphological characteristics of dendritic spines.
A Govindarajan +30 more
core +2 more sources
Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid
Science Signaling, 2019 LIMK1 inhibitors might provide protection from β-amyloid in patients at high risk for Alzheimer’s disease. Halting the onset of amyloid-induced dementia The appearance of β-amyloid (Aβ) plaques in the brain is strongly correlated with advanced Alzheimer ...
Benjamin W. Henderson +9 more
semanticscholar +1 more source
Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease
Neural Plasticity, 2012 Synapses are sites of cell-cell contacts that transmit electrical or chemical signals in the brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are located.
Wendou Yu, Bingwei Lu
doaj +1 more source
Scientific Reports, 2023 Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine dynamics. Previously, we have shown that a low dose chronic THC treatment improves learning abilities in old whereas impairs ...
Joanna Agnieszka Komorowska-Müller +5 more
doaj +1 more source
Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]
, 2016 During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo +5 more
core +2 more sources
Disease Models & Mechanisms, 2022 Dendritic spines are the principal site of excitatory synapse formation in the human brain. Several neurodevelopmental disorders cause spines to develop abnormally, resulting in altered spine number and morphology.
Elisabeth C. DeMarco +2 more
doaj +1 more source
Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability [PDF]
, 2015 Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Smolen, Paul
core +4 more sources
Translational Psychiatry, 2018 Stress is a major risk factor for the onset of many psychiatric diseases. In rodent models, chronic stress induces depression and impairs excitatory neurotransmission.
Lhotse Hei Lui Ng +5 more
semanticscholar +1 more source
Dendritic spine pathology in schizophrenia [PDF]
Neuroscience, 2013 Schizophrenia is a neurodevelopmental disorder whose clinical features include impairments in perception, cognition and motivation. These impairments reflect alterations in neuronal circuitry within and across multiple brain regions that are due, at least in part, to deficits in dendritic spines, the site of most excitatory synaptic connections ...
J R, Glausier, D A, Lewis
openaire +2 more sources
Neural Plasticity, 2012 Alterations in dendritic spines have been documented in numerous neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, an X chromosome-linked disorder associated with mutations in MECP2, is the leading cause of ...
Christopher A. Chapleau +5 more
doaj +1 more source