Results 41 to 50 of about 87,585 (230)

Chronic low-dose Δ9-tetrahydrocannabinol (THC) treatment stabilizes dendritic spines in 18-month-old mice

Scientific Reports, 2023
Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine dynamics. Previously, we have shown that a low dose chronic THC treatment improves learning abilities in old whereas impairs ...
Joanna Agnieszka Komorowska-Müller, Anne-Kathrin Gellner, Kishore Aravind Ravichandran, Andras Bilkei-Gorzo, Andreas Zimmer, Valentin Stein   +5 more
doaj   +1 more source

A genetic labeling system to study dendritic spine development in zebrafish models of neurodevelopmental disorders

Disease Models & Mechanisms, 2022
Dendritic spines are the principal site of excitatory synapse formation in the human brain. Several neurodevelopmental disorders cause spines to develop abnormally, resulting in altered spine number and morphology.
Elisabeth C. DeMarco, George R. Stoner, Estuardo Robles   +2 more
doaj   +1 more source

Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability [PDF]

, 2015
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Smolen, Paul
core   +4 more sources

Hippocampal CA1 Pyramidal Neurons of Mecp2 Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage

Neural Plasticity, 2012
Alterations in dendritic spines have been documented in numerous neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, an X chromosome-linked disorder associated with mutations in MECP2, is the leading cause of ...
Christopher A. Chapleau, Elena Maria Boggio, Gaston Calfa, Alan K. Percy, Maurizio Giustetto, Lucas Pozzo-Miller   +5 more
doaj   +1 more source

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density. [PDF]

PLoS ONE, 2016
The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuronal structure and function. Although these receptors share common signaling pathways, they are capable of having distinct effects on cellular plasticity ...
Kellie S Gross, Dieter D Brandner, Luis A Martinez, M Foster Olive, Robert L Meisel, Paul G Mermelstein   +5 more
doaj   +1 more source

Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]

, 2016
During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo, Lee, A-Ram, Lee, Hojae, Park, Chul-Seung, Song, Mi-Ryoung, Yoon, Yi-Seul   +5 more
core   +2 more sources

Image informatics strategies for deciphering neuronal network connectivity [PDF]

, 2016
Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions.
A Dani, A Rodriguez, A Rodriguez, A Rodriguez, B Deleglise, B Zhang, BA Wilt, C Sala, CG Dotti, D Cai, D Gerlich, D Popova, D Prodanov, D Smetters, DA Dombeck, DA Dombeck, DW Godwin, E Cohen, E Fluhler, E Meijering, E Meijering, E Meijering, EW Dent, F Cornelissen, F Janoos, G Pani, GG Gurkoff, GP Feng, GS Belinsky, H Bading, H Chen, H Peng, H Peng, HH Piao, IR Wickersham, IY Koh, J Cheng, J Fan, J Fan, J Lammerding, J Liu, J Livet, JA Harrill, JI Luebke, JL Chen, JM Nussbaum, K Chung, K Deisseroth, K Imamura, K Takahashi, KA Al-Kofahi, KD Micheva, KE Binley, KM Brown, KO Lai, KR Kay, L Bretzner, L Feng, L Grosenick, L Jin, L Jin, LD Costa, M Meijer, M Naujock, M Papa, M Pickering, M Pool, M Wittmann, ML Narro, MS Siegel, N Heck, O Sirenko, P Chothani, P Maiti, P Penzes, P Roqué, P Sarder, P Shi, P Verstraelen, Q Li, Q Li, R Nair, R Parekh, RA McKinney, RM Paredes, S Cho, S Schmitt, SK Schmitz, SL Wearne, SY Ho, SY Kim, T Nemoto, T Zhao, TL Fletcher, VA Alvarez, W Bai, WH Vos De, Y Al-Kofahi, Y Zhang, YC Lin   +99 more
core   +2 more sources

Low-intensity transcranial ultrasound stimulation improves memory in vascular dementia by enhancing neuronal activity and promoting spine formation

NeuroImage
Memory is closely associated with neuronal activity and dendritic spine formation. Low-intensity transcranial ultrasound stimulation (TUS) improves the memory of individuals with vascular dementia (VD).
Jiamin Pei, Cong Zhang, Xiao Zhang, Zhe Zhao, Xiangjian Zhang, Yi Yuan   +5 more
doaj   +1 more source

Dendritic Spines in the Spinal Cord: Live Action Pain

Neuroscience Insights, 2020
Dendritic spines are microscopic protrusions on neurons that house the postsynaptic machinery necessary for neurotransmission between neurons. As such, dendritic spine structure is intimately linked with synaptic function.
Curtis A Benson, Marike L Reimer, Andrew M Tan   +2 more
doaj   +1 more source

A Dynamin-3 Spliced Variant Modulates the Actin/Cortactin-Dependent Morphogenesis of Dendritic Spines [PDF]

, 2005
Immature dendrites extend many actin-rich filopodial structures that can be replaced by synapse-containing dendritic spines as the neuron matures. The large GTPase dynamin-3 (Dyn3) is a component of the postsynapse in hippocampal neurons but its function
Chen, Jing, Gray, Noah W., Kruchten, Anne E., McNiven, Mark A.   +3 more
core   +2 more sources