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The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines
Frontiers in Cellular Neuroscience, 2020 Kainate receptors (KAR) play a crucial role in the plasticity and functional maturation of glutamatergic synapses. However, how they regulate structural plasticity of dendritic spines is not known.
Sebnem Kesaf +14 more
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Dendritic spines are lost in clusters in Alzheimer’s disease [PDF]
Scientific Reports, 2021 Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation of tau in neurons is one of the hallmarks of AD and has been connected to the loss of dendritic ...
Mite Mijalkov +5 more
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Ecotoxicology and Environmental Safety, 2023 Lead (Pb), cadmium (Cd), and mercury (Hg) are environmentally toxic heavy metals that can be simultaneously detected at low levels in the blood of the general population. Although our previous studies have demonstrated neurodevelopmental toxicity upon co-
Fankun Zhou +17 more
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SpineTool is an open-source software for analysis of morphology of dendritic spines [PDF]
Scientific Reports, 2023 Dendritic spines form most excitatory synaptic inputs in neurons and these spines are altered in many neurodevelopmental and neurodegenerative disorders.
Ekaterina Pchitskaya +4 more
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DeepD3, an open framework for automated quantification of dendritic spines. [PDF]
PLoS Computational BiologyDendritic spines are the seat of most excitatory synapses in the brain, and a cellular structure considered central to learning, memory, and activity-dependent plasticity.
Martin H P Fernholz +3 more
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PLoS Biology, 2023 Dendritic spines, the tiny and actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain that control synaptic activity and plasticity.
Hsiao-Tang Hu +6 more
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Frontiers in Cellular Neuroscience, 2023 Dendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns.
Ali Özgür Argunsah +2 more
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Automated Remote Focusing, Drift Correction, and Photostimulation to Evaluate Structural Plasticity in Dendritic Spines. [PDF]
PLoS ONE, 2017 Long-term structural plasticity of dendritic spines plays a key role in synaptic plasticity, the cellular basis for learning and memory. The biochemical step is mediated by a complex network of signaling proteins in spines.
Michael S Smirnov +4 more
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Automated spatio-temporal analysis of dendritic spines and related protein dynamics. [PDF]
PLoS ONE, 2017 Cofilin and other Actin-regulating proteins are essential in regulating the shape of dendritic spines, which are sites of neuronal communications in the brain, and their malfunctions are implicated in neurodegeneration related to aging.
Vincent On +3 more
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Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleus. [PDF]
PLoS Computational Biology, 2008 Synapses on dendritic spines of pyramidal neurons show a remarkable ability to induce phosphorylation of transcription factors at the nuclear level with a short latency, incompatible with a diffusion process from the dendritic spines to the nucleus.
Isaac Shemer +3 more
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