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Sleep deprivation alters hippocampal dendritic spines in a contextual fear memory engram [PDF]
Scientific ReportsSleep is critically involved in strengthening memories. However, our understanding of the morphological changes underlying this process is still emerging.
Matthew Tennin +7 more
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Electrical advantages of dendritic spines.
PLoS ONE, 2012 Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the absence of spines, the amplitudes and kinetics of excitatory postsynaptic potentials (EPSPs) at the site of synaptic input are highly variable and depend
Allan T Gulledge +2 more
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Electrical properties of dendritic spines. [PDF]
Biophys J, 2023 Dendritic spines are small protrusions that mediate most of the excitatory synaptic transmission in the brain. Initially, the anatomical structure of spines has suggested that they serve as isolated biochemical and electrical compartments. Indeed, following ample experimental evidence, it is now widely accepted that a significant physiological role of ...
Zecevic D.
europepmc +3 more sources
DeepD3, an open framework for automated quantification of dendritic spines. [PDF]
PLoS Computational BiologyDendritic spines are the seat of most excitatory synapses in the brain, and a cellular structure considered central to learning, memory, and activity-dependent plasticity.
Martin H P Fernholz +3 more
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Superresolving Dendritic Spines [PDF]
Biophysical Journal, 2013 Spines are tiny protrusions that densely stud the dendrites of neurons in the brain. Individual spines are the primary recipients of synaptic inputs from single axons, which emanate from other neurons in the central nervous system. A dendritic tree on one neuron may have hundreds of thousands of spines, making connections to a corresponding number of ...
Loew, Leslie M., Hell, Stefan
openaire +5 more sources
The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. [PDF]
, 2015 The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process.
Gdalyahu, Amos +5 more
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Frontiers in Cellular Neuroscience, 2023 Dendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns.
Ali Özgür Argunsah +2 more
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Automated spatio-temporal analysis of dendritic spines and related protein dynamics. [PDF]
PLoS ONE, 2017 Cofilin and other Actin-regulating proteins are essential in regulating the shape of dendritic spines, which are sites of neuronal communications in the brain, and their malfunctions are implicated in neurodegeneration related to aging.
Vincent On +3 more
doaj +1 more source
Automated Remote Focusing, Drift Correction, and Photostimulation to Evaluate Structural Plasticity in Dendritic Spines. [PDF]
PLoS ONE, 2017 Long-term structural plasticity of dendritic spines plays a key role in synaptic plasticity, the cellular basis for learning and memory. The biochemical step is mediated by a complex network of signaling proteins in spines.
Michael S Smirnov +4 more
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Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleus. [PDF]
PLoS Computational Biology, 2008 Synapses on dendritic spines of pyramidal neurons show a remarkable ability to induce phosphorylation of transcription factors at the nuclear level with a short latency, incompatible with a diffusion process from the dendritic spines to the nucleus.
Isaac Shemer +3 more
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