Results 11 to 20 of about 70,784 (294)

Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway

open access: yesFrontiers in Neuroscience, 2022
Sevoflurane has become one of the most widely used volatile anesthetics in pediatric surgery. However, sevoflurane exposure may interfere with dendritic development and synaptogenesis, resulting in brain function impairment.
Linhong Zhong   +6 more
doaj   +1 more source

Increased spine PIP3 is sequestered from dendritic shafts

open access: yesMolecular Brain, 2022
Phosphatidylinositol 3,4,5-trisphosphate (PIP3) is a lipid second messenger that is crucial for the synaptic plasticity underlying learning and memory in pyramidal neurons in the brain. Our previous study uncovered PIP3 enrichment in the dendritic spines
Yoshibumi Ueda   +2 more
doaj   +1 more source

SpineTool is an open-source software for analysis of morphology of dendritic spines

open access: yesScientific Reports, 2023
Dendritic spines form most excitatory synaptic inputs in neurons and these spines are altered in many neurodevelopmental and neurodegenerative disorders.
Ekaterina Pchitskaya   +4 more
doaj   +1 more source

Analysis of dendritic spines morphology: from classical division to types toward alternative approaches

open access: yesSt. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019
Neuronal cells are characterized by a close relationship between their functional state and morphology, especially such mobile structures as dendritic spines.
Pchitskaya Ekaterina   +4 more
doaj   +1 more source

Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework [PDF]

open access: yes, 2005
The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we
Coombes, Stephen   +2 more
core   +2 more sources

Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties

open access: yesCell Reports, 2019
Summary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization.
Angelica Foggetti   +4 more
doaj   +1 more source

Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice

open access: yeseLife, 2023
Microglia, the resident immune cells of the brain, play a complex role in health and disease. They actively survey the brain parenchyma by physically interacting with other cells and structurally shaping the brain.
Felix Christopher Nebeling   +6 more
doaj   +1 more source

Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability [PDF]

open access: yes, 2015
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Smolen, Paul
core   +4 more sources

Small, smaller… dendritic spine [PDF]

open access: yesThe EMBO Journal, 2014
Spines are highly motile protrusions emerging from the dendritic shafts of neurons. The dynamics of these post‐synaptic structures are ruled by actin filament turnover. However, our understanding of the mechanisms of actin polymerization in dendritic spines is quite ambiguous.
Pietro, Pilo Boyl, Walter, Witke
openaire   +2 more sources

Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning [PDF]

open access: yes, 2013
The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the number of total and
Calfa, Gaston Diego   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy