Results 11 to 20 of about 553,059 (371)
The discovery of dendritic spines by Cajal [PDF]
Frontiers in Neuroanatomy, 2015 Dendritic spines were considered an artifact of the Golgi method until a brash Spanish histologist, Santiago Ramón y Cajal, bet his scientific career arguing that they were indeed real, correctly deducing their key role in mediating synaptic connectivity.
R. Yuste
semanticscholar +5 more sources
Lipid dynamics at dendritic spines [PDF]
Frontiers in Neuroanatomy, 2014 Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine
C. Dotti, J. Esteban, M. Ledesma
semanticscholar +6 more sources
Changing the size of dendritic spines. [PDF]
Elife, 2023 Interactions between an enzyme kinase, an ion channel and cytoskeletal proteins maintain the structure of synapses involved in memory formation.
Saneyoshi T.
europepmc +4 more sources
The role of dendritic spines in epileptogenesis. [PDF]
Front Cell Neurosci, 2023 Epilepsy is a chronic central nervous system (CNS) disease associated with high morbidity. To date, there is no known disease-modifying therapy for epilepsy. A leading hypothesis for a mechanism of epileptogenesis is the generation of aberrant neuronal networks.
Jean G, Carton J, Haq K, Musto AE.
europepmc +4 more sources
Superresolving Dendritic Spines [PDF]
Biophysical Journal, 2013 Spines are tiny protrusions that densely stud the dendrites of neurons in the brain. Individual spines are the primary recipients of synaptic inputs from single axons, which emanate from other neurons in the central nervous system. A dendritic tree on one neuron may have hundreds of thousands of spines, making connections to a corresponding number of ...
Loew, Leslie M., Hell, Stefan
openaire +4 more sources
The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. [PDF]
, 2015 The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process.
Gdalyahu, Amos +5 more
core +9 more sources
Automated Remote Focusing, Drift Correction, and Photostimulation to Evaluate Structural Plasticity in Dendritic Spines. [PDF]
PLoS ONE, 2017 Long-term structural plasticity of dendritic spines plays a key role in synaptic plasticity, the cellular basis for learning and memory. The biochemical step is mediated by a complex network of signaling proteins in spines.
Michael S Smirnov +4 more
doaj +1 more source
Automated spatio-temporal analysis of dendritic spines and related protein dynamics. [PDF]
PLoS ONE, 2017 Cofilin and other Actin-regulating proteins are essential in regulating the shape of dendritic spines, which are sites of neuronal communications in the brain, and their malfunctions are implicated in neurodegeneration related to aging.
Vincent On +3 more
doaj +1 more source
Pathology of Synapses and Dendritic Spines [PDF]
Neural Plasticity, 2012 Peer ...
Shira Knafo +3 more
openaire +6 more sources
Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleus. [PDF]
PLoS Computational Biology, 2008 Synapses on dendritic spines of pyramidal neurons show a remarkable ability to induce phosphorylation of transcription factors at the nuclear level with a short latency, incompatible with a diffusion process from the dendritic spines to the nucleus.
Isaac Shemer +3 more
doaj +1 more source