Results 21 to 30 of about 70,784 (294)

A Dynamin-3 Spliced Variant Modulates the Actin/Cortactin-Dependent Morphogenesis of Dendritic Spines [PDF]

, 2005
Immature dendrites extend many actin-rich filopodial structures that can be replaced by synapse-containing dendritic spines as the neuron matures. The large GTPase dynamin-3 (Dyn3) is a component of the postsynapse in hippocampal neurons but its function
Chen, Jing, Gray, Noah W., Kruchten, Anne E., McNiven, Mark A.   +3 more
core   +2 more sources

Lamina-specific AMPA receptor dynamics following visual deprivation in vivo. [PDF]

, 2020
Regulation of AMPA receptor (AMPAR) expression is central to synaptic plasticity and brain function, but how these changes occur in vivo remains elusive.
Cudmore, Robert H, Graves, Austin R, Huganir, Richard L, Roth, Richard H, Tan, Han L   +4 more
core   +2 more sources

Signaling in dendritic spines and spine microdomains [PDF]

Current Opinion in Neurobiology, 2012
The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical ...
Yao, Chen, Bernardo L, Sabatini
openaire   +2 more sources

Attenuation of Synaptic Potentials in Dendritic Spines

Cell Reports, 2017
Summary: Dendritic spines receive the majority of excitatory inputs in many mammalian neurons, but their biophysical properties and exact role in dendritic integration are still unclear.
Taekyung Kwon, Masayuki Sakamoto, Darcy S. Peterka, Rafael Yuste   +3 more
doaj   +1 more source

Travelling waves in a model of quasi-active dendrites with active spines [PDF]

, 2010
Dendrites, the major components of neurons, have many different types of branching structures and are involved in receiving and integrating thousands of synaptic inputs from other neurons.
Abbott, Alvarez, Baer, Bhatt, Bloodgood, Bressloff, Brown, Cajal, Cook, Coombes, Coombes, Coombes, Coombes, Coombes, Cox, Hodgkin, James, Johnston, Katz, Koch, Larkum, Lord, Magee, Mauro, Mel, Miller, Miller, Narayanan, Scott, Segal, Segev, Shepherd, Spruston, Svoboda, Timofeeva, Timofeeva, Timofeeva, Tsay, Ulrich, Williams, Y. Timofeeva   +40 more
core   +1 more source

Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus

Neural Plasticity, 2016
Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate the　development and maintenance of dendritic spines is limited.
Xiaohua Jin, Kodai Sasamoto, Jun Nagai, Yuki Yamazaki, Kenta Saito, Yoshio Goshima, Takafumi Inoue, Toshio Ohshima   +7 more
doaj   +1 more source

Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an "all-or-nothing" communication switch between the spine head and dendrite.

PLoS Computational Biology, 2022
Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle ...
James Rosado, Viet Duc Bui, Carola A Haas, Jürgen Beck, Gillian Queisser, Andreas Vlachos   +5 more
doaj   +1 more source

Rapid, learning-induced inhibitory synaptogenesis in murine barrel field [PDF]

, 2010
The structure of neurons changes during development and in response to injury or alteration in sensory experience. Changes occur in the number, shape, and dimensions of dendritic spines together with their synapses. However, precise data on these changes
Cybulska-Klosowicz, A, Furness, DN, Glazewski, S, Jasinska, M, Kossut, M, Pyza, E, Siucinska, E   +6 more
core   +1 more source

3D morphology-based clustering and simulation of human pyramidal cell dendritic spines.

PLoS Computational Biology, 2018
The dendritic spines of pyramidal neurons are the targets of most excitatory synapses in the cerebral cortex. They have a wide variety of morphologies, and their morphology appears to be critical from the functional point of view. To further characterize
Sergio Luengo-Sanchez, Isabel Fernaud-Espinosa, Concha Bielza, Ruth Benavides-Piccione, Pedro Larrañaga, Javier DeFelipe   +5 more
doaj   +1 more source

The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines

Frontiers in Cellular Neuroscience, 2020
Kainate receptors (KAR) play a crucial role in the plasticity and functional maturation of glutamatergic synapses. However, how they regulate structural plasticity of dendritic spines is not known.
Sebnem Kesaf, Sebnem Kesaf, Stanislav Khirug, Emilie Dinh, Marta Saez Garcia, Shetal Soni, Ester Orav, Ester Orav, Eric Delpire, Tomi Taira, Tomi Taira, Sari E. Lauri, Sari E. Lauri, Claudio Rivera, Claudio Rivera   +14 more
doaj   +1 more source