Results 21 to 30 of about 553,059 (371)
Frontiers in Neuroscience, 2022 Sevoflurane has become one of the most widely used volatile anesthetics in pediatric surgery. However, sevoflurane exposure may interfere with dendritic development and synaptogenesis, resulting in brain function impairment.
Linhong Zhong +6 more
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BDNF signaling during the lifetime of dendritic spines
Cell and Tissue Research, 2020 Dendritic spines are tiny membrane specialization forming the postsynaptic part of most excitatory synapses. They have been suggested to play a crucial role in regulating synaptic transmission during development and in adult learning processes.
M. Zagrebelsky +2 more
semanticscholar +1 more source
Increased spine PIP3 is sequestered from dendritic shafts
Molecular Brain, 2022 Phosphatidylinositol 3,4,5-trisphosphate (PIP3) is a lipid second messenger that is crucial for the synaptic plasticity underlying learning and memory in pyramidal neurons in the brain. Our previous study uncovered PIP3 enrichment in the dendritic spines
Yoshibumi Ueda +2 more
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Signaling in dendritic spines and spine microdomains [PDF]
Current Opinion in Neurobiology, 2012 The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical ...
Bernardo L. Sabatini, Yao Chen
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Dendritic Spines in Alzheimer’s Disease: How the Actin Cytoskeleton Contributes to Synaptic Failure
International Journal of Molecular Sciences, 2020 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by Aβ-driven synaptic dysfunction in the early phases of pathogenesis. In the synaptic context, the actin cytoskeleton is a crucial element to maintain the dendritic spine ...
S. Pelucchi +2 more
semanticscholar +1 more source
Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease
The Neuroscientist, 2020 Cognitive resilience is often defined as the ability to remain cognitively normal in the face of insults to the brain. These insults can include disease pathology, such as plaques and tangles associated with Alzheimer’s disease, stroke, traumatic brain ...
Courtney K. Walker, Jeremy H. Herskowitz
semanticscholar +1 more source
Dendritic Spine Plasticity and Cognition [PDF]
Neural Plasticity, 2012 The scientific studies of dendritic spines have experienced an overwhelming growth in the last three decades. Since the primary concept that dendritic spines are sites of excitatory synaptic contact, the most recent studies have led to theoretical proposals that relate spines' morphophysiology with the information processing that underlies cognition ...
Irina Nikonenko +2 more
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Diffusion laws in dendritic spines [PDF]
The Journal of Mathematical Neuroscience, 2011 Dendritic spines are small protrusions on a neuronal dendrite that are the main locus of excitatory synaptic connections. Although their geometry is variable over time and along the dendrite, they typically consist of a relatively large head connected to the dendritic shaft by a narrow cylindrical neck.
David Holcman +2 more
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St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019 Neuronal cells are characterized by a close relationship between their functional state and morphology, especially such mobile structures as dendritic spines.
Pchitskaya Ekaterina +4 more
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Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework [PDF]
, 2005 The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we
Coombes, Stephen +2 more
core +2 more sources