Results 21 to 30 of about 43,830 (285)

Signaling in dendritic spines and spine microdomains [PDF]

Current Opinion in Neurobiology, 2012
The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical ...
Yao, Chen, Bernardo L, Sabatini
openaire   +2 more sources

Attenuation of Synaptic Potentials in Dendritic Spines

Cell Reports, 2017
Summary: Dendritic spines receive the majority of excitatory inputs in many mammalian neurons, but their biophysical properties and exact role in dendritic integration are still unclear.
Taekyung Kwon, Masayuki Sakamoto, Darcy S. Peterka, Rafael Yuste   +3 more
doaj   +1 more source

Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an "all-or-nothing" communication switch between the spine head and dendrite.

PLoS Computational Biology, 2022
Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle ...
James Rosado, Viet Duc Bui, Carola A Haas, Jürgen Beck, Gillian Queisser, Andreas Vlachos   +5 more
doaj   +1 more source

Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus

Neural Plasticity, 2016
Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate the　development and maintenance of dendritic spines is limited.
Xiaohua Jin, Kodai Sasamoto, Jun Nagai, Yuki Yamazaki, Kenta Saito, Yoshio Goshima, Takafumi Inoue, Toshio Ohshima   +7 more
doaj   +1 more source

3D morphology-based clustering and simulation of human pyramidal cell dendritic spines.

PLoS Computational Biology, 2018
The dendritic spines of pyramidal neurons are the targets of most excitatory synapses in the cerebral cortex. They have a wide variety of morphologies, and their morphology appears to be critical from the functional point of view. To further characterize
Sergio Luengo-Sanchez, Isabel Fernaud-Espinosa, Concha Bielza, Ruth Benavides-Piccione, Pedro Larrañaga, Javier DeFelipe   +5 more
doaj   +1 more source

Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL

Biological Research, 2023
Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain.
Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li, Songhe Jiang   +10 more
doaj   +1 more source

KLHL17/Actinfilin, a brain-specific gene associated with infantile spasms and autism, regulates dendritic spine enlargement

Journal of Biomedical Science, 2020
Background Dendritic spines, the actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain. Many actin-regulating molecules modulate dendritic spine morphology.
Hsiao-Tang Hu, Tzyy-Nan Huang, Yi-Ping Hsueh   +2 more
doaj   +1 more source

The ‘addicted’ spine.

Frontiers in Neuroanatomy, 2014
Units of dendritic branches called dendritic spines represent more than simply decorative appendages of the neuron and actively participate in integrative functions of ‘spinous’ nerve cells thereby contributing to the general phenomenon of synaptic ...
Saturnino eSpiga, Giovanna eMulas, Francesca ePiras, Marco eDiana   +3 more
doaj   +1 more source

NESH regulates dendritic spine morphology and synapse formation. [PDF]

PLoS ONE, 2012
BackgroundDendritic spines are small membranous protrusions on the neuronal dendrites that receive synaptic input from axon terminals. Despite their importance for integrating the enormous information flow in the brain, the molecular mechanisms ...
Jeomil Bae, Bong Hwan Sung, In Ha Cho, Seon-Myung Kim, Woo Keun Song   +4 more
doaj   +1 more source

Investigating sub-spine actin dynamics in rat hippocampal neurons with super-resolution optical imaging.

PLoS ONE, 2009
Morphological changes in dendritic spines represent an important mechanism for synaptic plasticity which is postulated to underlie the vital cognitive phenomena of learning and memory.
Vedakumar Tatavarty, Eun-Ji Kim, Vladimir Rodionov, Ji Yu   +3 more
doaj   +1 more source