Results 31 to 40 of about 70,784 (294)

Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]

, 2016
During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo, Lee, A-Ram, Lee, Hojae, Park, Chul-Seung, Song, Mi-Ryoung, Yoon, Yi-Seul   +5 more
core   +2 more sources

Dendritic Spine Shape Analysis: A Clustering Perspective [PDF]

, 2016
Functional properties of neurons are strongly coupled with their morphology. Changes in neuronal activity alter morphological characteristics of dendritic spines.
A Govindarajan, A Lipson, A Peters, A Rodriguez, AK Jain, B Ruszczycki, CD Harvey, F Chang, F Mesadi, IY Koh, J Bourne, J Lippman, J Son, J Spacek, J Tonnesen, JB Tenenbaum, JI Arellano, JJ Mancuso, JW Wallis, M Matsuzaki, P Mitra, PT So, R Yuste, R Yuste, TF Chan, TM Cover, W Bai, W Wallace, X Xu, Y Zhang, Z Parnass   +30 more
core   +2 more sources

Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL

Biological Research, 2023
Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain.
Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li, Songhe Jiang   +10 more
doaj   +1 more source

Co-exposure to low-dose lead, cadmium, and mercury promotes memory deficits in rats: Insights from the dynamics of dendritic spine pruning in brain development

Ecotoxicology and Environmental Safety, 2023
Lead (Pb), cadmium (Cd), and mercury (Hg) are environmentally toxic heavy metals that can be simultaneously detected at low levels in the blood of the general population. Although our previous studies have demonstrated neurodevelopmental toxicity upon co-
Fankun Zhou, Lu Ouyang, Jie Xie, Sisi Liu, Qi Li, Shuo Yang, Jiajun Li, Rui Su, Shaoqi Rao, Lingyu Yan, Xin Wan, Hui Cheng, Peishan Liu, Lingling Li, Yanhui Zhu, Guihua Du, Chang Feng, Guangqin Fan   +17 more
doaj   +1 more source

Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. [PDF]

, 2017
In neurons, lysosomes, which degrade membrane and cytoplasmic components, are thought to primarily reside in somatic and axonal compartments, but there is little understanding of their distribution and function in dendrites.
Bloodgood, Brenda L, Boassa, Daniela, Deerinck, Thomas J, Ellisman, Mark H, Goo, Marisa S, Patrick, Gentry N, Sancho, Laura, Slepak, Natalia   +7 more
core   +1 more source

KLHL17/Actinfilin, a brain-specific gene associated with infantile spasms and autism, regulates dendritic spine enlargement

Journal of Biomedical Science, 2020
Background Dendritic spines, the actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain. Many actin-regulating molecules modulate dendritic spine morphology.
Hsiao-Tang Hu, Tzyy-Nan Huang, Yi-Ping Hsueh   +2 more
doaj   +1 more source

Image informatics strategies for deciphering neuronal network connectivity [PDF]

, 2016
Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions.
A Dani, A Rodriguez, A Rodriguez, A Rodriguez, B Deleglise, B Zhang, BA Wilt, C Sala, CG Dotti, D Cai, D Gerlich, D Popova, D Prodanov, D Smetters, DA Dombeck, DA Dombeck, DW Godwin, E Cohen, E Fluhler, E Meijering, E Meijering, E Meijering, EW Dent, F Cornelissen, F Janoos, G Pani, GG Gurkoff, GP Feng, GS Belinsky, H Bading, H Chen, H Peng, H Peng, HH Piao, IR Wickersham, IY Koh, J Cheng, J Fan, J Fan, J Lammerding, J Liu, J Livet, JA Harrill, JI Luebke, JL Chen, JM Nussbaum, K Chung, K Deisseroth, K Imamura, K Takahashi, KA Al-Kofahi, KD Micheva, KE Binley, KM Brown, KO Lai, KR Kay, L Bretzner, L Feng, L Grosenick, L Jin, L Jin, LD Costa, M Meijer, M Naujock, M Papa, M Pickering, M Pool, M Wittmann, ML Narro, MS Siegel, N Heck, O Sirenko, P Chothani, P Maiti, P Penzes, P Roqué, P Sarder, P Shi, P Verstraelen, Q Li, Q Li, R Nair, R Parekh, RA McKinney, RM Paredes, S Cho, S Schmitt, SK Schmitz, SL Wearne, SY Ho, SY Kim, T Nemoto, T Zhao, TL Fletcher, VA Alvarez, W Bai, WH Vos De, Y Al-Kofahi, Y Zhang, YC Lin   +99 more
core   +2 more sources

The ‘addicted’ spine.

Frontiers in Neuroanatomy, 2014
Units of dendritic branches called dendritic spines represent more than simply decorative appendages of the neuron and actively participate in integrative functions of ‘spinous’ nerve cells thereby contributing to the general phenomenon of synaptic ...
Saturnino eSpiga, Giovanna eMulas, Francesca ePiras, Marco eDiana   +3 more
doaj   +1 more source

The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]

, 2016
Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F., Aliaga, E., Díaz-Véliz, G., Fiedler, J.L., Fresno, C., García-Rojo, G., Mora, S., Pacheco, A., Parra, C.S., Parra-Fiedler, N., Rojas, P.S., Tejos, M., Vilches, N.   +12 more
core   +1 more source

Investigating sub-spine actin dynamics in rat hippocampal neurons with super-resolution optical imaging.

PLoS ONE, 2009
Morphological changes in dendritic spines represent an important mechanism for synaptic plasticity which is postulated to underlie the vital cognitive phenomena of learning and memory.
Vedakumar Tatavarty, Eun-Ji Kim, Vladimir Rodionov, Ji Yu   +3 more
doaj   +1 more source