Results 31 to 40 of about 553,059 (371)

The spine problem: finding a function for dendritic spines [PDF]

Frontiers in Neuroanatomy, 2014
Why do neurons have dendritic spines? This question-the heart of what Yuste calls "the spine problem"-presupposes that why-questions of this sort have scientific answers: that empirical findings can favor or count against claims about why neurons have spines. Here we show how such questions can receive empirical answers.
Sarah Malanowski, Carl F. Craver
openaire   +3 more sources

Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties

Cell Reports, 2019
Summary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization.
Angelica Foggetti, Gilda Baccini, Philipp Arnold, Thomas Schiffelholz, Peer Wulff   +4 more
doaj   +1 more source

Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice

eLife, 2023
Microglia, the resident immune cells of the brain, play a complex role in health and disease. They actively survey the brain parenchyma by physically interacting with other cells and structurally shaping the brain.
Felix Christopher Nebeling, Stefanie Poll, Lena Christine Justus, Julia Steffen, Kevin Keppler, Manuel Mittag, Martin Fuhrmann   +6 more
doaj   +1 more source

Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning [PDF]

, 2013
The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the number of total and
Calfa, Gaston Diego, Giachero, Marcelo, Molina, Víctor Alejandro   +2 more
core   +1 more source

Dendritic Spine Shape Analysis: A Clustering Perspective [PDF]

, 2016
Functional properties of neurons are strongly coupled with their morphology. Changes in neuronal activity alter morphological characteristics of dendritic spines.
A Govindarajan, A Lipson, A Peters, A Rodriguez, AK Jain, B Ruszczycki, CD Harvey, F Chang, F Mesadi, IY Koh, J Bourne, J Lippman, J Son, J Spacek, J Tonnesen, JB Tenenbaum, JI Arellano, JJ Mancuso, JW Wallis, M Matsuzaki, P Mitra, PT So, R Yuste, R Yuste, TF Chan, TM Cover, W Bai, W Wallace, X Xu, Y Zhang, Z Parnass   +30 more
core   +2 more sources

Travelling waves in a model of quasi-active dendrites with active spines [PDF]

, 2010
Dendrites, the major components of neurons, have many different types of branching structures and are involved in receiving and integrating thousands of synaptic inputs from other neurons.
Abbott, Alvarez, Baer, Bhatt, Bloodgood, Bressloff, Brown, Cajal, Cook, Coombes, Coombes, Coombes, Coombes, Coombes, Cox, Hodgkin, James, Johnston, Katz, Koch, Larkum, Lord, Magee, Mauro, Mel, Miller, Miller, Narayanan, Scott, Segal, Segev, Shepherd, Spruston, Svoboda, Timofeeva, Timofeeva, Timofeeva, Tsay, Ulrich, Williams, Y. Timofeeva   +40 more
core   +1 more source

Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability [PDF]

, 2015
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Smolen, Paul
core   +4 more sources

Lamina-specific AMPA receptor dynamics following visual deprivation in vivo. [PDF]

, 2020
Regulation of AMPA receptor (AMPAR) expression is central to synaptic plasticity and brain function, but how these changes occur in vivo remains elusive.
Cudmore, Robert H, Graves, Austin R, Huganir, Richard L, Roth, Richard H, Tan, Han L   +4 more
core   +2 more sources

Calcium Dynamics in Dendritic Spines and Spine Motility [PDF]

Biophysical Journal, 2004
A dendritic spine is an intracellular compartment in synapses of central neurons. The role of the fast twitching of spines, brought about by a transient rise of internal calcium concentration above that of the parent dendrite, has been hitherto unclear.
David Holcman, Zeev Schuss, Eduard Korkotian   +2 more
openaire   +3 more sources

Attenuation of Synaptic Potentials in Dendritic Spines

Cell Reports, 2017
Summary: Dendritic spines receive the majority of excitatory inputs in many mammalian neurons, but their biophysical properties and exact role in dendritic integration are still unclear.
Taekyung Kwon, Masayuki Sakamoto, Darcy S. Peterka, Rafael Yuste   +3 more
doaj   +1 more source