Ecotoxicology and Environmental Safety, 2023 Lead (Pb), cadmium (Cd), and mercury (Hg) are environmentally toxic heavy metals that can be simultaneously detected at low levels in the blood of the general population. Although our previous studies have demonstrated neurodevelopmental toxicity upon co-
Fankun Zhou +17 more
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Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]
, 2016 During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo +5 more
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Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo
eLife, 2018 Rewiring neural circuits by the formation and elimination of synapses is thought to be a key cellular mechanism of learning and memory in the mammalian brain.
T. Pfeiffer +13 more
semanticscholar +1 more source
NESH regulates dendritic spine morphology and synapse formation. [PDF]
PLoS ONE, 2012 BackgroundDendritic spines are small membranous protrusions on the neuronal dendrites that receive synaptic input from axon terminals. Despite their importance for integrating the enormous information flow in the brain, the molecular mechanisms ...
Jeomil Bae +4 more
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The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM [PDF]
, 2016 The formation of synaptic connections during nervous system development requires the precise control of dendrite growth and synapse formation. Although glial cell line-derived neurotrophic factor (GDNF) and its receptor GFRα1 are expressed in the ...
Alsina, Fernando Cruz +5 more
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The Role of Actin Cytoskeleton in Dendritic Spines in the Maintenance of Long-Term Memory
Frontiers in Molecular Neuroscience, 2018 Evidence indicates that long-term memory formation involves alterations in synaptic efficacy produced by modifications in neural transmission and morphology.
Sreetama Basu, R. Lamprecht
semanticscholar +1 more source
Paradoxical signaling regulates structural plasticity in dendritic spines [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance The basis for learning and memory formation is in tiny (1−2 μm) membranous protrusions along short branched extensions (dendrites) of nerve cells (neurons) called dendritic spines.
P. Rangamani +3 more
semanticscholar +1 more source
Frontiers in Neuroanatomy, 2014 Units of dendritic branches called dendritic spines represent more than simply decorative appendages of the neuron and actively participate in integrative functions of ‘spinous’ nerve cells thereby contributing to the general phenomenon of synaptic ...
Saturnino eSpiga +3 more
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The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]
, 2016 Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F. +12 more
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Computational geometry analysis of dendritic spines by structured illumination microscopy
Nature Communications, 2019 Dendritic spines are the postsynaptic sites that receive most of the excitatory synaptic inputs, and thus provide the structural basis for synaptic function.
Yutaro Kashiwagi +6 more
semanticscholar +1 more source