Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines
Nature Communications, 2019 Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) in dendritic spines is a key step of long-term potentiation (LTP) induction, yet the exact biochemical steps of CaMKIIα activation in dendritic spines remained elusive. In this study, the authors
Jui-Yun Chang +3 more
doaj +1 more source
Actin capping protein regulates postsynaptic spine development through CPI-motif interactions
Frontiers in Molecular Neuroscience, 2022 Dendritic spines are small actin-rich protrusions essential for the formation of functional circuits in the mammalian brain. During development, spines begin as dynamic filopodia-like protrusions that are then replaced by relatively stable spines ...
Kenneth R. Myers +6 more
doaj +1 more source
The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus [PDF]
, 2010 Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder.
Baquet +74 more
core +4 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins.
PLoS ONE, 2016 Climbing fibres and parallel fibres compete for dendritic space on Purkinje cells in the cerebellum. Normally, climbing fibres populate the proximal dendrites, where they suppress the multiple small spines typical of parallel fibres, leading to their ...
Tristan G Heintz +2 more
doaj +1 more source
Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. [PDF]
, 2019 Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes.
Bartol, Tom +3 more
core
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 [PDF]
, 2016 Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage.
Abel, Ted +14 more
core +5 more sources
Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024
FEBS Open Bio, EarlyView.The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior +5 more
wiley +1 more source
Dendritic spines are lost in clusters in Alzheimer’s disease
Scientific Reports, 2021 Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation of tau in neurons is one of the hallmarks of AD and has been connected to the loss of dendritic ...
Mite Mijalkov +5 more
doaj +1 more source
Dendritic Spines as Tunable Regulators of Synaptic Signals
Frontiers in Psychiatry, 2016 Neurons are perpetually receiving vast amounts of information in the form of synaptic input from surrounding cells. The majority of input occurs at thousands of dendritic spines, which mediate excitatory synaptic transmission in the brain, and is ...
A. Rasia-Filho +3 more
semanticscholar +1 more source