Results 151 to 160 of about 40,867 (262)

A phase 1 study of ASTX727 plus talazoparib in patients with triple‐negative or hormone resistant/HER2‐negative metastatic breast cancer

Cancer, Volume 132, Issue 8, 15 April 2026.
Abstract Background Poly(adenosine diphosphate ribose) polymerase (PARP) is recruited to DNA damage sites along with epigenetic factors such as DNA methyltransferase 1 (DNMT1). Inhibitors of DNMT modulate reactive oxygen species (ROS)‐cyclic adenosine monophosphate (cAMP)/Protein Kinase A signaling and induce a “BRCAness phenotype” that further ...
Kathy D. Miller, Alexandra Thomas, Sandra Althouse, Yong Zang, Erin Conder, Ryan Burgos, Bryan P. Schneider, Tarah Ballinger, Emily Douglas, Katherine Ansley, H. Josh Jang, Woonbok Chung, Jean‐Pierre Issa, Kenneth P. Nephew, Feyruz V. Rassool   +14 more
wiley   +1 more source

Optimizing bone health in lymphoma survivors: denosumab superiority to alendronate for R-CHOP-like therapy (the DENOSULY phase III randomized controlled trial)

Haematologica
Glucocorticoid-induced osteoporosis (GIOP) poses a critical long-term complication for lymphoma survivors, with cumulative incidence of fractures following R-CHOP-like therapy.
Shohei Kikuchi, Eiju Negoro, Ryusuke Horaguchi, Takuma Fujihira, Yoshimi Nabe, Tomoki Minemura, Kento Ono, Yusuke Kamihara, Akinori Wada, Nam H. Dang, Yasufumi Masaki, Toshihiro Miyamoto, Takahiro Yamauchi, Tsutomu Sato   +13 more
doaj   +1 more source

Effect of denosumab on the incidence of fractures and mortality in patients undergoing hemodialysis: A retrospective cohort study.

PLoS ONE
BackgroundPatients undergoing hemodialysis are at an elevated risk of fractures; however, substantial evidence for osteoporosis treatment in this population is lacking.
Arisa Kobayashi, Tatsuhiro Yaginuma, Kazuhiko Kato, Akio Nakashima, Ichiro Ohkido, Takashi Yokoo   +5 more
doaj   +1 more source

JMT103 versus Non‐Denosumab or Denosumab Treatment in Chinese Patients with Unresectable or Surgically Challenging Giant Cell Tumor of Bone: A Propensity Score‐Matched Comparison

Cancer Medicine
Background Giant cell tumors of bone (GCTB) are RANK/RANK‐ligand positive, progressive osteolytic tumors. There was no medical treatment for GCTB based on efficacy and safety data from Chinese patients.
Hairong Xu, Yong Zhou, Feng Wei, Yi Ding, Huachao Shan, Yongkun Yang, Weifeng Liu, Tao Jin, Yi Luo, Fan Tang, Minxun Lu, Xin He, Wenli Zhang, Shaomin Yang, Lihua Zhang, Juan Wang, Hong Li, Chongqi Tu, Xiaohui Niu   +18 more
doaj   +1 more source

AGO Recommendations for Diagnosis and Treatment of Patients with Early and Metastatic Breast Cancer: Update 2012 [PDF]

, 2011
Harbeck, Nadia, Scharl, Anton, Thomssen, Christoph   +2 more
core   +2 more sources

Il trattamento riabilitativo integrato alla terapia farmacologica con anticorpo anti RANK-L [PDF]

, 2015
pubblicato su atti ...
Asaro, C., Culmone, F., Lauricella, L., LETIZIA MAURO, G., Palermo, A., Scaturro, D., Tumminelli, L.   +6 more
core  

Increased breast tissue receptor activator of nuclear factor- κB ligand (RANKL) gene expression is associated with higher mammographic density in premenopausal women [PDF]

, 2017
Appleton, Catherine M, Colditz, Graham A, Dang, Ha X, Hagemann, Ian S, Luo, Jingqin, Maher, Christopher A, Toriola, Adetunji T   +6 more
core   +2 more sources

Pediatric Bipolar disorder, in Malta is it under-diagnosed? [PDF]

, 2012
The objective of this retrospective study was to determine the frequency of Bipolar Disorder in children and adolescents referred to the Child Guidance Clinic (CGC), St. Luke’s Hospital, Malta, over a year.
Camilleri, Nigel, Cassar Parnis, Abigail, Cassar, Joseph, Zahra, Anthony   +3 more
core  

Denosumab Treatment of Severe Disuse Osteoporosis in a Boy With Spinal Muscular Atrophy

Acta Medica Iranica, 2017
Denosumab is a fully human recombinant monoclonal antibody to the receptor activator of nuclear factor-κB ligand. Denosumab is used in the treatment of postmenopausal osteoporosis and cancer-related bone disorders.
Stepan Kutilek
doaj  

What\u27s new in orthopaedic trauma [PDF]

, 2013
Gardner, Michael, McAndrew, Christopher, Ricci, William M, Spiguel, Andre   +3 more
core   +2 more sources