Results 91 to 100 of about 117,269 (356)

Remifentanil alleviates transient cerebral ischemia-induced memory impairment through suppression of apoptotic neuronal cell death in gerbils [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundDuring neurosurgical procedures, patients are often exposed to hypoxic and ischemic brain damage. Cerebral ischemia leads to neuronal cell death and eventually causes neurological impairments.
Sung-Wook Park, Jae-Woo Yi, Young-Min Kim, Jong-Man Kang, Dong Ok Kim, Mal-Soon Shin, Chang-Ju Kim, Doo Ik Lee, Dong-Hee Kim, Bong Jae Lee   +9 more
doaj   +1 more source

The effect of Urtica dioica extract on the number of astrocytes in the dentate gyrus of diabetic rats [PDF]

, 2009
Diabetes mellitus is associated with cerebral alterations in both human and animal models of the disease. These alterations include abnormal expression of hypothalamic neuropeptides and hippocampal astrogliosis.
Afshar, M., Golalipour, M.J., Jahanshahi, M.   +2 more
core  

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

MDMA Increases Excitability in the Dentate Gyrus: Role of 5HT2A Receptor Induced PGE2 Signaling [PDF]

, 2016
MDMA is a widely abused psychostimulant which causes release of serotonin in various forebrain regions. Recently, we reported that MDMA increases extracellular glutamate concentrations in the dentate gyrus, via activation of 5HT2A receptors.
Chiaia, Nicolas, Collins, Stuart A., Gudelsky, Gary A., Huff, Courtney, Yamamoto, Bryan K.   +4 more
core   +1 more source

Dentate gyrus and hilar region revisited [PDF]

Behavioral and Brain Sciences, 2016
AbstractIt is suggested that the dentate gyrus and hilar region in the hippocampus perform memory selection and that the selectivity of the gating of memory by this circuit is modulated by the norepinephrine–glutamate loop described by Mather et al.
openaire   +4 more sources

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats.

PLoS ONE, 2015
Estradiol increases cell proliferation in the dentate gyrus of the female rodent but it is not known whether the G protein-coupled estrogen receptor (GPER), a membrane receptor, is involved in this process, nor whether there are regional differences in ...
Paula Duarte-Guterman, Stephanie E Lieblich, Carmen Chow, Liisa A M Galea   +3 more
doaj   +1 more source

Extended Interneuronal Network of the Dentate Gyrus [PDF]

Cell Reports, 2017
Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and ...
Gergely G. Szabo, Xi Du, Mikko Oijala, Csaba Varga, Jack M. Parent, Ivan Soltesz   +5 more
openaire   +3 more sources

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. [PDF]

, 2015
Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed
Alvarez, Victor E, Bieniek, Kevin F, Cairns, Nigel J, Crary, John F, Dams-O'Connor, Kristen, Dickson, Dennis W, Folkerth, Rebecca D, Gordon, Wayne A, Keene, C Dirk, Litvan, Irene, McKee, Ann C, Perl, Daniel P, Stein, Thor D, Stewart, William, TBI/CTE group, Tripodis, Yorghos, Vonsattel, Jean-Paul   +16 more
core   +3 more sources