Results 91 to 100 of about 131,553 (328)

What is the functional role of adult neurogenesis in the hippocampus? [PDF]

open access: yes, 2004
The dentate gyrus is part of the hippocampal memory system and special in that it generates new neurons throughout life. Here we discuss the question of what the functional role of these new neurons might be.
Kempermann, Gerd   +2 more
core   +1 more source

Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells

open access: yesNature Communications, 2016
The hippocampus is critical for the acquisition and retrieval of episodic and contextual memories. Lesions of the dentate gyrus, a principal input of the hippocampus, block memory acquisition, but it remains unclear whether this region also plays a role ...
N. Madroñal   +11 more
semanticscholar   +1 more source

The Relationship between Rest Tremor and Underlying Lewy Pathology in Essential Tremor: A Clinical‐Pathological Study of 201 Cases

open access: yesAnnals of Neurology, EarlyView.
Objectives Prospective studies demonstrated that essential tremor is a risk factor for Parkinson's disease. Identifying clinical markers for conversion from essential tremor to essential tremor‐Parkinson's disease would be of considerable value. Rest tremor can be present in advanced essential tremor and may be a harbinger of conversion. We examined (1)
Elan D. Louis   +3 more
wiley   +1 more source

Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer’s Disease

open access: yesASN Neuro, 2019
There is growing evidence from epidemiological studies that especially midlife physical activity might exert a positive influence on the risk and progression of Alzheimer’s disease.
Anna-Lina Gerberding   +4 more
doaj   +1 more source

Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis

open access: yesJournal of Developmental Biology, 2020
We have previously described hypomorphic reelin (Reln) mutant mice, RelnCTRdel, in which the morphology of the dentate gyrus is distinct from that seen in reeler mice.
Seungshin Ha   +4 more
doaj   +1 more source

Cortistain is expressed in a distinct subset of cortical interneurons [PDF]

open access: yes, 1997
Cortistatin is a presumptive neuropeptide that shares 11 of its 14 amino acids with somatostatin. In contrast to somatostatin, administration of cortistatin into the rat brain ventricles specifically enhances slow wave sleep, apparently by antagonizing ...
Alcántara Horrillo, Soledad   +8 more
core  

Anatolian ground squirrel (Spermophilus xanthoprymnus) retina: Comparative expression of synaptophysin, NeuN, calbindin‐D28k, parvalbumin, glial fibrillary acidic protein, and Iba‐1 during pre‐hibernation and hibernation

open access: yesThe Anatomical Record, EarlyView.
Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek   +5 more
wiley   +1 more source

Recognition Memory Dysfunction Relates to Hippocampal Subfield Volume: A Study of Cognitively Normal and Mildly Impaired Older Adults. [PDF]

open access: yes, 2018
ObjectivesThe current study examined recognition memory dysfunction and its neuroanatomical substrates in cognitively normal older adults and those diagnosed with mild cognitive impairment (MCI).MethodsParticipants completed the Mnemonic Similarity Task,
Bennett, Ilana J   +2 more
core   +2 more sources

The CA3 “backprojection” to the dentate gyrus [PDF]

open access: yes, 2007
The hippocampus is typically described in the context of the trisynaptic circuit, a pathway that relays information from the perforant path to the dentate gyrus, dentate to area CA3, and CA3 to area CA1. Associated with this concept is the assumption that most hippocampal information processing occurs along the trisynaptic circuit.
openaire   +3 more sources

Dentate gyrus and hilar region revisited [PDF]

open access: yesBehavioral and Brain Sciences, 2016
AbstractIt is suggested that the dentate gyrus and hilar region in the hippocampus perform memory selection and that the selectivity of the gating of memory by this circuit is modulated by the norepinephrine–glutamate loop described by Mather et al.
openaire   +5 more sources

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